Novel markers of kidney injury in bipolar patients on long-term lithium treatment

2013 ◽  
Vol 28 (6) ◽  
pp. 615-618 ◽  
Author(s):  
Janusz K. Rybakowski ◽  
Maria Abramowicz ◽  
Maria Chłopocka-Wozniak ◽  
Stanislaw Czekalski
Keyword(s):  
Lithium Treatment ◽  
Kidney Injury ◽  
Bipolar Patients

Decreased leukocyte telomere length in male patients with chronic bipolar disorder: lack of effect of long-term lithium-treatment

2021 ◽  
pp. 1-25
Author(s):  
Ewa Ferensztajn-Rochowiak ◽  
Ewa Kurczewska ◽  
Błażej Rubiś ◽  
Michalina Lulkiewicz ◽  
Hanna Hołysz ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Telomere Length ◽  
Lithium Treatment ◽  
Quantitative Polymerase Chain Reaction ◽  
Accelerated Aging ◽  
Control Group ◽  
Duration Of Treatment ◽  
Control Male ◽  
Bipolar Patients

Abstract Objectives: Bipolar disorder (BD) may be connected with accelerated aging, the marker of this can be shorter telomere length (TL). Some data suggest that lithium may exert a protective effect against telomere shortening. The study aimed to compare the telomere length between patients with bipolar disorder and control subjects. The effect of long-term lithium treatment was also assessed. Methods: The study group comprised 41 patients with BD, including 29 patients treated longitudinally with lithium (mean 16.5 years) and 20 healthy people. Telomere length was assessed by the quantitative polymerase chain reaction (qPCR). Results: In the control group, the TL was significantly longer in males than in females. Male bipolar patients had significantly shorter TL compared with the control male group. In bipolar patients, there was no correlation between TL and duration of treatment. The TL was negatively correlated with age in male bipolar patients. Conclusion: The study did not confirm the lithium effect on TL in bipolar patients. TL showed gender differences, being shorter in BD males, compared to control males, and longer in healthy males, compared to control females.

Social Support and Long-Term Lithium Outcome

1985 ◽  
Vol 147 (3) ◽  
pp. 272-275 ◽  
Author(s):  
Ralph A. O'Connell ◽  
Julia A. Mayo ◽  
Leonard K. Eng ◽  
J. Sidney Jones ◽  
Richard H. Gabel
Keyword(s):  
Social Support ◽  
Psychosocial Factors ◽  
Social Adjustment ◽  
Lithium Treatment ◽  
Bipolar Affective Disorder ◽  
Global Assessment Scale ◽  
Factors Affecting ◽  
One Year ◽  
Bipolar Patients

SummaryThe failure rate in long-term lithium treatment of bipolar affective disorder is in the range of 20 to 30%, even with rigorous diagnostic criteria and adequate serum lithium levels. This may be due to a variety of biologic and psychosocial factors. Psychosocial factors affecting treatment outcome were studied in 60 RDC diagnosed bipolar patients treated with lithium for one year. Outcome was measured using an affective episode score, a social adjustment scale and a global assessment scale. Social support was the factor most strongly correlated with a good outcome on all three measures.

Stem cells, pluripotency and glial cell markers in peripheral blood of bipolar patients on long-term lithium treatment

2018 ◽  
Vol 80 ◽  
pp. 28-33 ◽  
Author(s):  
Ewa Ferensztajn-Rochowiak ◽  
Jolanta Kucharska-Mazur ◽  
Maciej Tarnowski ◽  
Jerzy Samochowiec ◽  
Mariusz Z. Ratajczak ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glial Cell ◽  
Peripheral Blood ◽  
Lithium Treatment ◽  
Cell Markers ◽  
Bipolar Patients ◽  
Glial Cell Markers

Kidney functioning during short and long-term lithium treatment in bipolar patients

1999 ◽  
Vol 9 ◽  
pp. 215-216 ◽  
Author(s):  
S. Sofuoǧlu ◽  
C. Utaş ◽  
S.S. Aslan ◽  
C. Yalçindaǧ ◽  
M. Baştürk ◽  
...  
Keyword(s):  
Lithium Treatment ◽  
Short And Long Term ◽  
Bipolar Patients

P.2.d.005 Correlation between kidney function and ultrasonographic findings in bipolar patients receiving long-term lithium treatment

2015 ◽  
Vol 25 ◽  
pp. S413
Author(s):  
M. Abramowicz ◽  
K. Jończyk-Potoczna ◽  
M. Chłopocka-Woźniak ◽  
L. Strzelczuk-Judka ◽  
M. Michalak ◽  
...  
Keyword(s):  
Kidney Function ◽  
Lithium Treatment ◽  
Bipolar Patients

Renal sonography in bipolar patients on long-term lithium treatment

2016 ◽  
Vol 44 (6) ◽  
pp. 354-359 ◽  
Author(s):  
Katarzyna Jończyk-Potoczna ◽  
Maria Abramowicz ◽  
Maria Chłopocka-Woźniak ◽  
Lidia Strzelczuk-Judka ◽  
Michał Michalak ◽  
...  
Keyword(s):  
Lithium Treatment ◽  
Renal Sonography ◽  
Bipolar Patients

A Retrospective Case Series of Bipolar Patients With Adjunctive Carbamazepine in Long-Term Lithium Treatment

2011 ◽  
Vol 31 (4) ◽  
pp. 538-540 ◽  
Author(s):  
Valeria Deiana ◽  
Caterina Chillotti ◽  
Mirko Manchia ◽  
Martina Pinna ◽  
Raffaella Ardau ◽  
...  
Keyword(s):  
Lithium Treatment ◽  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Bipolar Patients

No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies

2019 ◽  
Vol 52 (05) ◽  
pp. 232-236 ◽  
Author(s):  
Agnieszka Kraszewska ◽  
Katarzyna Ziemnicka ◽  
Jerzy Sowiński ◽  
Ewa Ferensztajn-Rochowiak ◽  
Janusz K. Rybakowski
Keyword(s):  
Filtration Rate ◽  
Lithium Treatment ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Free Triiodothyronine ◽  
Antithyroid Antibodies ◽  
Female Patients ◽  
Bipolar Patients

Abstract Introduction The studies on the effect of lithium treatment on antithyroid antibodies showed either a higher concentration of these antibodies in patients receiving lithium compared to those lithium-naive or no difference between these groups. In lithium-treated bipolar patients, some researchers pointed to an association between antithyroid antibodies and other features of thyroid dysfunction such as hypothyroidism and decrease of glomerular filtration rate. Methods We compared antithyroid antibodies in 98 patients (30 male, 68 female) with bipolar disorder, aged 62±13 years, who received lithium for 19±10 years to 39 patients (12 male, 27 female), aged 57±10 years, who were never treated with lithium. The antibodies against thyroid peroxidase (TPOAb), against thyroglobulin (TGAb), and thyroid-stimulating hormone (TSH) receptors (TSHRAb) were estimated. Results No difference in the percentages of antibodies occurrence was found between groups, although the concentrations of TGAb were higher in patients receiving lithium. In lithium-treated patients, the presence of TPOAb was associated with lower concentrations of free triiodothyronine and the presence of TGAb, with higher concentrations of TSH. In females, the levels of TGAb were associated with lower thyroid volume. The concentrations of TPOAb correlated positively with the duration of lithium therapy in males, and those of TPOAb and TGAb negatively, with such duration, in female patients. Conclusion The results obtained showed no significant connection between long-term lithium treatment and antithyroid antibodies. In bipolar patients receiving lithium longitudinally, antithyroid antibodies can be associated with some indexes of thyroid function. However, they behave differently in male and female patients.

P.1.188 Thyroidal hormone profile in bipolar patients who were in short and long-term lithium treatment

1997 ◽  
Vol 7 ◽  
pp. S194
Author(s):  
Seher Sofouǧlu ◽  
Ahmet Tutuş ◽  
Ali Saffet Gönül ◽  
Mustafa Baştürk ◽  
Kader Köse ◽  
...  
Keyword(s):  
Lithium Treatment ◽  
Hormone Profile ◽  
Short And Long Term ◽  
Bipolar Patients

Outcome of Bipolar Disorder on Long-Term Treatment with Lithium

1991 ◽  
Vol 159 (1) ◽  
pp. 123-129 ◽  
Author(s):  
Ralph A. O'Connell ◽  
Julia A. Mayo ◽  
Leslie Flatow ◽  
Beverly Cuthbertson ◽  
Barbara E. O'Brien
Keyword(s):  
Bipolar Disorder ◽  
Treatment Outcome ◽  
Lithium Treatment ◽  
Term Treatment ◽  
Poor Outcome ◽  
Psychiatric Admissions ◽  
Long Term Treatment ◽  
Alcohol And Drug Abuse ◽  
Bipolar Patients

The long-term treatment outcome of 248 bipolar patients in an out-patient lithium programme was assessed. Over half of the patients (138 or 56%) had no affective episodes in the year observed. Patients were divided into outcome groups according to GAS scores: the outcome for 40% of patients was good, for 41% fair, and for 19% poor. More frequent psychiatric admissions before starting lithium treatment was the best predictor of poor outcome, followed by a negative affective style in the family and lower social class. Current alcohol and drug abuse was associated with poor outcome. Although familial and psychosocial factors were significantly associated with outcome, the findings suggest there may be inherent differences in the pathophysiology of bipolar disorder reflected in an increased frequency of episodes which account for a large variance in lithium treatment outcome.

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