Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: a double-blind, placebo-controlled study of orthostatic challenge, blood pressure and heart rate

2013 ◽  
Vol 28 (6) ◽  
pp. 562-575 ◽  
Author(s):  
Alison Diaper ◽  
Ann S. Rich ◽  
Sue J. Wilson ◽  
Kevin Craig ◽  
Colin T. Dourish ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Healthy Volunteers ◽  
Cardiovascular Function ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Orthostatic Challenge

Flunarizine I.V. in the Acute Treatment of the Migraine Attack. A Double-Blind Placebo-Controlled Study

Cephalalgia ◽  
1988 ◽  
Vol 8 (8_suppl) ◽  
pp. 35-40 ◽  
Author(s):  
Dieter Soyka ◽  
Ziya Taneri ◽  
Wolfgang Oestreich ◽  
Rainer Schmidt
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Migraine Attack ◽  
Acute Treatment ◽  
Controlled Study ◽  
Complete Relief ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Accompanying Symptoms ◽  
Observation Period

Flunarizine, 20 mg by slow intravenous injection, was studied in the acute treatment of migraine attacks in a multicentre, double-blind, placebo-controlled study. At the end of the 60 min observation period, 23 of the 31 (74.2%) patients treated with flunarizine reported complete relief, or a pain reduction of more than 50%, vs. 8 of 29 (27.6%) placebo patients ( p < 0.017). Accompanying symptoms also improved significantly better in the flunarizine than in the placebo group. The investigators evaluated the therapy as good or excellent in 77.4% of the flunarizine and in 27.6% of the placebo patients, respectively. Tolerance of the therapy was good and comparable in the two groups. Somnolence was the only flunarizinerelated adverse reaction. Blood pressure and heart rate were not affected. Flunarizine i.v. deserves further study in the acute treatment of a migraine attack.

Propranolol in Experimentally Induced Stress

1981 ◽  
Vol 139 (6) ◽  
pp. 545-549 ◽  
Author(s):  
Elizabeth A. Taylor ◽  
Paul Turner ◽  
Jean Harrison
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Oral Dose ◽  
Systolic Blood Pressure ◽  
Healthy Volunteers ◽  
The Self ◽  
Experimental Stress ◽  
Double Blind ◽  
Beta Adrenoceptor ◽  
Induced Stress

SummaryThe influence of beta-adrenoceptor antagonism on the effects of a simple experimental stress was investigated in 12 healthy volunteers, using a double-blind protocol. A single oral dose of 80 mg propranolol reduced the stress-induced increase in heart rate and systolic blood pressure to 49.9 per cent and 8.3 per cent respectively compared to 61.0 per cent and 17.4 per cent with placebo. The rise in diastolic blood pressure was small and unaffected by beta-adrenoceptor blockade. The rise in temperature of the skin of the trunk was significantly reduced by propranolol. The self-rating of anxiety, alertness and concentration by the subjects was unaffected by propranolol.

scholarly journals Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers

2013 ◽  
Vol 10 (1) ◽  
pp. 48 ◽  
Author(s):  
James P Lugo ◽  
Zainulabedin M Saiyed ◽  
Francis C Lau ◽  
Jhanna Pamela L Molina ◽  
Michael N Pakdaman ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Type Ii Collagen ◽  
Controlled Study ◽  
Type Ii ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Undenatured Type Ii Collagen

scholarly journals The Prophylactic Antiemetic Efficacy of Prochlorperazine and Ondansetron in Nasal Septal Surgery: A Randomized Double-Blind Comparison

1996 ◽  
Vol 24 (5) ◽  
pp. 538-545 ◽  
Author(s):  
A. A. Van Den Berg
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiovascular Effects ◽  
Controlled Study ◽  
Postoperative Vomiting ◽  
Double Blind ◽  
Septal Surgery ◽  
Postoperative Headache ◽  
Per Se ◽  
Blind Comparison

A prospective, randomized placebo-controlled study was undertaken to compare the effects on heart rate and blood pressure during surgery and on the incidence of nausea, vomiting and headache after surgery of IM prochlorperazine 0.2 mg.kg-1, IV prochlorperazine 0.1 mg.kg-1 and IV ondansetron 0.06 mg.kg-1 given at induction of general anaesthesia to patients undergoing septorhinoplasty. The effects of the test drugs after administration on heart rate and blood pressure were similar, as were the incidences of retching and vomiting in the recovery ward after each test drug. Postoperatively, compared with placebo (7%), nausea per se was most frequent in those given IV prochlorperazine (25%, P<0.01), and less frequent in those given IM prochlorperazine (2%) and IV ondansetron (15%). Vomiting per se was reduced from 24% to 7% (P<0.025) by IV prochlorperazine and to 4% (P<0.0005) by IV ondansetron. The incidence of nausea with vomiting was reduced from 35% to 15% (P<0.025), 16% (P<0.05) and 11% (P<0.005) by IM prochlorperazine, IV prochlorperazine and IV ondansetron respectively. IM prochlorperazine and IV ondansetron increased the frequency (from 35% to 64%, P<0.0005 and to 71%, P<0.0005, respectively) of those experiencing no PONV and delayed the onset of PONV, but only IM prochlorperazine reduced the severity of postoperative vomiting. Headache was frequent in the control (69%), IV prochlorperazine (62%) and IV ondansetron (69%) groups, and least frequent after IM prochlorperazine (53%; P<0.05 versus IV ondansetron). It is concluded that these drugs have no adverse cardiovascular effects within 10 minutes of administration, IM prochlorperazine and IV ondansetron reduce PONV more effectively than IV prochlorperazine and postoperative headache after septorhinoplasty occurs less frequently in those given IM prochlorperazine than in those given IV ondansetron.

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