Determination of the loudness dependence of auditory evoked potentials: single-electrode estimation versus dipole source analysis

2011 ◽  
Vol 26 (2) ◽  
pp. 147-154 ◽  
Author(s):  
Florence Hagenmuller ◽  
Konrad Hitz ◽  
Felix Darvas ◽  
Wolfram Kawohl
Keyword(s):  
Evoked Potentials ◽  
Auditory Evoked Potentials ◽  
Source Analysis ◽  
Dipole Source ◽  
Dipole Source Analysis ◽  
Loudness Dependence

566 Dipole source analysis of P300 component of the auditory evoked potentials

1998 ◽  
Vol 30 (1-2) ◽  
pp. 216
Author(s):  
T. Locatellil ◽  
P. Ravazzani ◽  
S. Medaglini ◽  
M. Cursil ◽  
F. Grandori ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Auditory Evoked Potentials ◽  
Source Analysis ◽  
Dipole Source ◽  
P300 Component ◽  
Dipole Source Analysis

Dipole Source Analysis of Laser-Evoked Subdural Potentials Recorded From Parasylvian Cortex in Humans

2003 ◽  
Vol 89 (6) ◽  
pp. 3051-3060 ◽  
Author(s):  
Hagen Vogel ◽  
John D. Port ◽  
Fred A. Lenz ◽  
Meiyappan Solaiyappan ◽  
Greg Krauss ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Auditory Evoked Potentials ◽  
Posterior Part ◽  
Sylvian Fissure ◽  
Source Analysis ◽  
Dipole Source ◽  
Projection Area ◽  
Global Field Power ◽  
Noxious Heat ◽  
Dipole Source Analysis

The location of the human nociceptive area(s) near the Sylvian fissure is still controversial in spite of evidence from imaging and evoked potential studies that noxious heat stimuli activate somatosensory areas in that region. Some studies have suggested the secondary somatosensory cortex (SII) on the upper bank of the Sylvian fissure posterior to the central sulcus, others the anterior insula or parietal area 7b. In this study, we applied dipole source analysis techniques to laser-evoked potentials (LEPs) that were recorded from subdural grid electrodes in three patients. As a functional marker, auditory-evoked potentials (AEPs) with a generator on the opposite bank of the Sylvian fissure were recorded from the same electrodes. The LEP global field power (GFP), a measure of spatial variance, showed a first peak at about 150 ms latency, corresponding to the latency of the N1 recorded from the scalp. In contrast to scalp recordings, the amplitude of the first GFP peak recorded from the grid was larger than the second peak (P2). This finding suggests that the generator of N1, but not that of later LEP components, was close to the subdural grids. When a regional source was fitted to the first GFP peak, its location was within the frontoparietal operculum in all patients. On average, the LEP source was 13 mm anterior, 6 mm superior, and 2 mm medial of the AEP source. This relative location also suggests a source within the frontoparietal operculum overlying the insula. At the latency of the first GFP peak, source orientation pointed inward, suggesting a generator within the inner vertical surface of the operculum. Somatotopy was assessed in one patient and was consistent with that of the projection area of the presumed nociceptive thalamic nucleus posterior part of the ventromedial nucleus, but differed from that of SII. These findings suggest that the nociceptive area in human parasylvian cortex that is activated most rapidly by noxious heat pulses may be separate from the tactile SII area.

A Source Analysis of the Late Human Auditory Evoked Potentials

1989 ◽  
Vol 1 (4) ◽  
pp. 336-355 ◽  
Author(s):  
Michael Scherg ◽  
Jiri Vajsar ◽  
Terence W. Picton
Keyword(s):  
Evoked Potentials ◽  
Mismatch Negativity ◽  
Auditory Evoked Potentials ◽  
Source Analysis ◽  
Dipole Source ◽  
Frequency Change ◽  
Negative Wave ◽  
Oriented Dipole ◽  
N1 Wave ◽  
Dipole Sources

The intracerebral generators of the human auditory evoked potentials were estimated using dipole source analysis of 14-channel scalp recordings. The response to a 400-msec toneburst presented every 0.9 sec could be explained by three major dipole sources in each temporal lobe. The first was a vertically oriented dipole located on the supratemporal plane in or near the auditory koniocortex. This contributed to the scalp-recorded N1 wave at 100 msec. The second was a vertically oriented dipole source located on the supratemporal plane somewhat anterior to the first. This contributed to both the Nl and the sustained potential (SP). The third was a laterally oriented dipole source that perhaps originated in the magnopyramidal temporal field. This contributed a negative wave to the lateral scalp recordings at the latency of 145 msec. A change in the frequency of the toneburst elicited an additional negativity in the scalp-recording —the mismatch negativity (MMN). When the frequency change was large, the mismatch negativity was composed of two distinct sources with sequential but partially overlapping activities. The earlier corresponded to the Nl dipole sources and the later to a more anteriorly located dipole with an orientation more lateral than Nl. Only the later source was active when the frequency change was small. MMN source activities peaked about 15 msec earlier in the contralateral hemisphere, while this difference was only 4 msec for the sources of the Nl.

Preoperative localization of the central sulcus by dipole source analysis of early somatosensory evoked potentials and three-dimensional magnetic resonance imaging

1994 ◽  
Vol 80 (5) ◽  
pp. 849-856 ◽  
Author(s):  
Helmut Buchner ◽  
Ludwig Adams ◽  
Achim Knepper ◽  
Rainer Rüger ◽  
Gabriel Laborde ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Evoked Potentials ◽  
Three Dimensional ◽  
Source Analysis ◽  
Dipole Source ◽  
Central Sulcus ◽  
Content Type ◽  
Dipole Source Analysis ◽  
Functional Localization ◽  
Fine Print

✓ Surgery of lesions within or close to the central area of the brain always carries the risk of iatrogenic motor or sensory deficits. Functional localization by means of intraoperative direct stimulation of the motor area or by recording somatosensory evoked potentials (SSEP's) from the surface of the somatosensory cortex is believed to reduce the operative risk. The authors introduce the combination of dipole source analysis of scalp-recorded SSEP's with three-dimensional (3-D) magnetic resonance (MR) imaging as a tool for preoperative localization of the central sulcus. This provides information on both functional and structural localization for preoperative planning. Four repeated measurements of right and left median nerve SSEP's were obtained from 20 subjects. Dipole source analysis showed a retest reliability of the 3-D localization error of 2.9 ± 2.0 mm. Compared to the MR evaluation, dipole source analysis was found to mark the central sulcus within 3 mm for 15 conditions (subjects × side of stimulation), while the 3-D MR measurement was accurate to within 6 mm for 10 conditions and 9 mm for 14 conditions. Dipole locations were confirmed in six patients who underwent surgery of the central region. With respect to this application, dipole source analysis combined with 3-D MR imaging appears to be a valuable tool for preoperative functional localization. The accuracy in localization will be further improved when realistic head models become available that can take into account individual head geometry. Further development of the proposed new method holds promise that evoked potentials and electroencephalography will gain greater use in presurgical functional localization.

Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials

2008 ◽  
Vol 23 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Georg Juckel ◽  
Wolfram Kawohl ◽  
Ina Giegling ◽  
Paraskevi Mavrogiorgou ◽  
Christine Winter ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Auditory Evoked Potentials ◽  
Loudness Dependence

scholarly journals Mismatch Negativity and Loudness Dependence of Auditory Evoked Potentials among Patients with Major Depressive Disorder, Bipolar II Disorder, and Bipolar I Disorder

2020 ◽  
Vol 10 (11) ◽  
pp. 789
Author(s):  
Yang Rae Kim ◽  
Young-Min Park
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Evoked Potentials ◽  
Mismatch Negativity ◽  
Auditory Evoked Potentials ◽  
Type I ◽  
Major Depressive ◽  
Serotonergic Activity ◽  
Related Potentials ◽  
Loudness Dependence

Mismatch negativity (MMN) and loudness dependence of auditory evoked potentials (LDAEP), which are event-related potentials, have been investigated as biomarkers. MMN indicates the pre-attentive function, while LDAEP may be an index of central serotonergic activity. This study aimed to test whether MMN and LDAEP are useful biological markers for distinguishing patients with bipolar disorder (BD) and major depressive disorder (MDD), as well as the relationship between MMN and LDAEP. Fifty-five patients with major depressive episodes, aged 20 to 65 years, who had MDD (n = 17), BD type II (BIID) (n = 27), and BD type I (BID) (n = 11), were included based on medical records. Patients with MDD had a higher MMN amplitude than those with BID. In addition, the MMN amplitude in F4 positively correlated with the Korean version of mood disorder questionnaire scores (r = 0.37, p = 0.014), while the MMN amplitude in F3 correlated negatively with LDAEP (r = −0.30, p = 0.024). The odds ratios for the BID group and some variables were compared with those for the MDD group using multinomial logistic regression analysis. As a result, a significant reduction of MMN amplitude was found under BID diagnosis compared to MDD diagnosis (p = 0.015). This study supported the hypothesis that MMN amplitude differed according to MDD, BIID, and BID, and there was a relationship between MMN amplitude and LDAEP. These findings also suggested that BID patients had a reduced automatic and pre-attentive processing associated with serotonergic activity or N-methyl-D-aspartate receptor.

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