Brain histamine H1 receptor occupancy of loratadine measured by positron emission topography: comparison of H1 receptor occupancy and proportional impairment ratio

Nobuo Kubo; Michio Senda; Yasunori Ohsumi; Setsu Sakamoto; Keiichi Matsumoto; Manabu Tashiro; Nobuyuki Okamura; Kazuhiko Yanai

doi:10.1002/hup.1184

Brain histamine H1 receptor occupancy of loratadine measured by positron emission topography: comparison of H1 receptor occupancy and proportional impairment ratio

Human Psychopharmacology Clinical and Experimental ◽

10.1002/hup.1184 ◽

2011 ◽

Vol 26 (2) ◽

pp. 133-139 ◽

Cited By ~ 23

Author(s):

Nobuo Kubo ◽

Michio Senda ◽

Yasunori Ohsumi ◽

Setsu Sakamoto ◽

Keiichi Matsumoto ◽

...

Keyword(s):

Receptor Occupancy ◽

H1 Receptor ◽

Brain Histamine ◽

Histamine H1 Receptor ◽

Positron Emission ◽

Histamine H1 Receptor Occupancy

Download Full-text

Histamine H1 Receptor Occupancy in the Human Brain Measured by Positron Emission Tomography

Histamine Receptors ◽

10.1007/978-3-319-40308-3_13 ◽

2016 ◽

pp. 311-325

Author(s):

Kazuhiko Yanai ◽

Kotaro Hiraoka ◽

Anikó Kárpáti ◽

Fumito Naganuma ◽

Nobuyuki Okamura ◽

...

Keyword(s):

Positron Emission Tomography ◽

Human Brain ◽

Receptor Occupancy ◽

Emission Tomography ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Positron Emission ◽

Histamine H1 Receptor Occupancy

Download Full-text

Brain histamine H1 receptor occupancy of orally administered antihistamines measured by positron emission tomography with 11C-doxepin in a placebo-controlled crossover study design in healthy subjects: a comparison of olopatadine and ketotifen

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.2005.02514.x ◽

2006 ◽

Vol 61 (1) ◽

pp. 16-26 ◽

Cited By ~ 49

Author(s):

Manabu Tashiro ◽

Hideki Mochizuki ◽

Yumiko Sakurada ◽

Kenji Ishii ◽

Keiichi Oda ◽

...

Keyword(s):

Positron Emission Tomography ◽

Crossover Study ◽

Study Design ◽

Healthy Subjects ◽

Receptor Occupancy ◽

Emission Tomography ◽

H1 Receptor ◽

Brain Histamine ◽

Positron Emission ◽

Histamine H1 Receptor Occupancy

Download Full-text

Histamine H1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers

Psychopharmacology ◽

10.1007/s00213-015-4002-2 ◽

2015 ◽

Vol 232 (19) ◽

pp. 3497-3505 ◽

Cited By ~ 13

Author(s):

Hirotoshi Sato ◽

Chihiro Ito ◽

Kotaro Hiraoka ◽

Manabu Tashiro ◽

Katsuhiko Shibuya ◽

...

Keyword(s):

Positron Emission Tomography ◽

Healthy Volunteers ◽

Receptor Occupancy ◽

Emission Tomography ◽

Positron Emission Tomography Study ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Positron Emission ◽

New Generation ◽

Histamine H1 Receptor Occupancy

Download Full-text

Neuroimaging of histamine H1 -receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine

British Journal of Clinical Pharmacology ◽

10.1046/j.1365-2125.2001.01471.x ◽

2001 ◽

Vol 52 (5) ◽

pp. 501-509 ◽

Cited By ~ 66

Author(s):

Masaaki Tagawa ◽

Michiko Kano ◽

Nobuyuki Okamura ◽

Makoto Higuchi ◽

Michiaki Matsuda ◽

...

Keyword(s):

Positron Emission Tomography ◽

Comparative Study ◽

Human Brain ◽

Second Generation ◽

Receptor Occupancy ◽

Emission Tomography ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Positron Emission ◽

Histamine H1 Receptor Occupancy

Download Full-text

Central Effects of Fexofenadine and Cetirizine: Measurement of Psychomotor Performance, Subjective Sleepiness, and Brain Histamine H1-Receptor Occupancy Using11C-Doxepin Positron Emission Tomography

The Journal of Clinical Pharmacology ◽

10.1177/0091270004267590 ◽

2004 ◽

Vol 44 (8) ◽

pp. 890-900 ◽

Cited By ~ 89

Author(s):

Manabu Tashiro ◽

Yumiko Sakurada ◽

Kentaro Iwabuchi ◽

Hideki Mochizuki ◽

Motohisa Kato ◽

...

Keyword(s):

Positron Emission Tomography ◽

Psychomotor Performance ◽

Receptor Occupancy ◽

Emission Tomography ◽

H1 Receptor ◽

Brain Histamine ◽

Central Effects ◽

Positron Emission ◽

Subjective Sleepiness ◽

Histamine H1 Receptor Occupancy

Download Full-text

Dose dependency of brain histamine H1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin

Human Psychopharmacology Clinical and Experimental ◽

10.1002/hup.1051 ◽

2009 ◽

Vol 24 (7) ◽

pp. 540-548 ◽

Cited By ~ 33

Author(s):

Manabu Tashiro ◽

Motohisa Kato ◽

Masayasu Miyake ◽

Shoichi Watanuki ◽

Yoshihito Funaki ◽

...

Keyword(s):

Oral Administration ◽

Receptor Occupancy ◽

Dose Dependency ◽

H1 Receptor ◽

Brain Histamine ◽

Histamine H1 Receptor ◽

Cetirizine Hydrochloride ◽

Histamine H1 Receptor Occupancy

Download Full-text

Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers

Psychopharmacology ◽

10.1007/s00213-013-3146-1 ◽

2013 ◽

Vol 230 (2) ◽

pp. 227-234 ◽

Cited By ~ 12

Author(s):

Hirotoshi Sato ◽

Chihiro Ito ◽

Manabu Tashiro ◽

Kotaro Hiraoka ◽

Katsuhiko Shibuya ◽

...

Keyword(s):

Positron Emission Tomography ◽

Healthy Volunteers ◽

Receptor Occupancy ◽

Emission Tomography ◽

Positron Emission Tomography Study ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Positron Emission ◽

New Generation ◽

Histamine H1 Receptor Occupancy

Download Full-text

Histamine H1 receptor occupancy in the brain under living conditions after single oral doses of antihistamines: basic animal experiments and human PET studies.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)50946-5 ◽

1994 ◽

Vol 64 ◽

pp. 328

Author(s):

Kazuhiko Yanai ◽

Jong Hoon Ryu ◽

Takehiko Watanabe

Keyword(s):

Animal Experiments ◽

Receptor Occupancy ◽

Living Conditions ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Oral Doses ◽

The Brain ◽

Histamine H1 Receptor Occupancy

Download Full-text

Histamine H1 receptor occupancy in the human brain after single oral doses of antihistamines measured by PET.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)36339-5 ◽

1996 ◽

Vol 71 ◽

pp. 19

Author(s):

Kazuhiko Yanai ◽

Takehiko Watanabe

Keyword(s):

Human Brain ◽

Receptor Occupancy ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Oral Doses ◽

Histamine H1 Receptor Occupancy

Download Full-text

Sedative profiles of antihistamine drugs evaluated by subjective sleepiness, cognitive tests, and PET for measurement of cerebral histamine H1 receptor occupancy

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0416 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S416-S416

Author(s):

Manabu Tashiro ◽

Yumiko Sakurada ◽

Hideki Mochizuki ◽

Etsuo Horikawa ◽

Motohisa Kato ◽

...

Keyword(s):

Receptor Occupancy ◽

Cognitive Tests ◽

H1 Receptor ◽

Histamine H1 Receptor ◽

Subjective Sleepiness ◽

Histamine H1 Receptor Occupancy ◽

Antihistamine Drugs

Download Full-text