The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss

2006 ◽  
Vol 27 (8) ◽  
pp. 786-795 ◽  
Author(s):  
Lut Van Laer ◽  
Per-Inge Carlsson ◽  
Natacha Ottschytsch ◽  
Marie-Louise Bondeson ◽  
Annelies Konings ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Noise Induced Hearing Loss ◽  
Potassium Recycling

scholarly journals Ultrasound Microbubbles Enhance the Efficacy of Insulin-Like Growth Factor-1 Therapy for the Treatment of Noise-Induced Hearing Loss

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3626
Author(s):  
Yi-Chun Lin ◽  
Yuan-Yung Lin ◽  
Hsin-Chien Chen ◽  
Chao-Yin Kuo ◽  
Ai-Ho Liao ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Growth Factor ◽  
Inner Ear ◽  
Outer Hair Cells ◽  
Round Window Membrane ◽  
Insulin Like Growth Factor ◽  
Noise Induced Hearing Loss ◽  
Ear Diseases ◽  
Brainstem Response ◽  
Ultrasound Microbubbles

The application of insulin-like growth factor 1 (IGF-1) to the round window membrane (RWM) is an emerging treatment for inner ear diseases. RWM permeability is the key factor for efficient IGF-1 delivery. Ultrasound microbubbles (USMBs) can increase drug permeation through the RWM. In the present study, the enhancing effect of USMBs on the efficacy of IGF-1 application and the treatment effect of USMB-mediated IGF-1 delivery for noise-induced hearing loss (NIHL) were investigated. Forty-seven guinea pigs were assigned to three groups: the USM group, which received local application of recombinant human IGF-1 (rhIGF-1, 10 µg/µL) following application of USMBs to the RWM; the RWS group, which received IGF-1 application alone; and the saline-treated group. The perilymphatic concentration of rhIGF-1 in the USM group was 1.95- and 1.67- fold of that in the RWS group, 2 and 24 h after treatment, respectively. After 5 h of 118 dB SPL noise exposure, the USM group had the lowest threshold shift in auditory brainstem response, least loss of cochlear outer hair cells, and least reduction in the number of synaptic ribbons on postexposure day 28 among the three groups. The combination of USMB and IGF-1 led to a better therapeutic response to NIHL. Two hours after treatment, the USM group had significantly higher levels of Akt1 and Mapk3 gene expression than the other two groups. The most intense immunostaining for phosphor-AKT and phospho-ERK1/2 was detected in the cochlea in the USM group. These results suggested that USMB can be applied to enhance the efficacy of IGF-1 therapy in the treatment of inner ear diseases.

scholarly journals A Human Inner Ear Model for assessment of Noise Induced Hearing Loss via energy methods

2020 ◽  
Vol 53 (2) ◽  
pp. 16424-16429
Author(s):  
Milka C.I. Madahana ◽  
Otis T.C. Nyandoro ◽  
John E.D. Ekoru
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Energy Methods ◽  
Noise Induced Hearing Loss ◽  
Human Inner Ear

scholarly journals Noise Induced Hearing Loss: A Case Study from a Speech-Language Pathologist’s Perspective

2021 ◽  
Author(s):  
Alejandro Brice
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Hearing Aids ◽  
Noise Exposure ◽  
Chronic Health Condition ◽  
Noise Induced Hearing Loss ◽  
Speech Language Pathologist ◽  
The Individual ◽  
The U.S

Hearing loss is very common in the United States and the most widespread disability in the U.S. Hearing loss is the third most chronic health condition in the U.S. Noise induced hearing loss (NIHL) results from damaging external noise. This injury leads to temporarily or permanently affecting sensitive inner ear structures (e.g., cochlea, organ of Corti, and hair cells). NIHL can result from a single high-level noise exposure or repeated exposures to excessively loud noises [i.e., typically 85 dBA or greater, (A weighted decibel)]. Damage to the inner ear can also result from aging (i.e., presbycusis). This case study documents the hearing loss of an otherwise healthy 21-year-old, male individual and his progressive moderate-to-severe sensorineural hearing loss over a period of 41 years. His history will be reported along with his perspective as a speech-language pathologist and speech scientist. The individual with hearing loss has adapted to wearing hearing aids over the last five years. Issues that have occurred affecting comprehension along with compensatory strategies that assisted listening and comprehension will be discussed.

The inner ear

2009 ◽  
pp. 109-148
Author(s):  
Rogan Corbridge ◽  
Nicholas Steventon
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Sudden Hearing Loss ◽  
Structure And Function ◽  
Noise Induced Hearing Loss ◽  
Hereditary Hearing Loss ◽  
Syndromic Hearing Loss ◽  
And Function

Structure and function of the inner ear 110 Hearing loss 114 Presbyacusis 116 Noise-induced hearing loss 118 Idiopathic sudden hearing loss 120 Autoimmune ear disease 122 Ototoxicity 124 Hereditary hearing loss 126 Syndromic hearing loss I 128 Syndromic hearing loss II 130 Non-organic hearing loss (NOHL) ...

Analysis of Gene Polymorphisms Associated with K+Ion Circulation in the Inner Ear of Patients Susceptible and Resistant to Noise-induced Hearing Loss

2009 ◽  
Vol 73 (4) ◽  
pp. 411-421 ◽  
Author(s):  
Malgorzata Pawelczyk ◽  
Lut Van Laer ◽  
Erik Fransen ◽  
Elzbieta Rajkowska ◽  
Annelies Konings ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Gene Polymorphisms ◽  
Noise Induced Hearing Loss

scholarly journals Noise-induced hearing loss in zebrafish: investigating structural and functional inner ear damage and recovery

2020 ◽  
Vol 391 ◽  
pp. 107952 ◽  
Author(s):  
Lukas Breitzler ◽  
Ieng Hou Lau ◽  
Paulo J. Fonseca ◽  
Raquel O. Vasconcelos
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Noise Induced Hearing Loss ◽  
Inner Ear Damage

The inner ear

2019 ◽  
pp. 117-161
Author(s):  
Rogan Corbridge ◽  
Nicholas Steventon
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Bone Fractures ◽  
Auditory Neuropathy ◽  
Spectrum Disorder ◽  
Noise Induced Hearing Loss ◽  
Hearing Rehabilitation ◽  
Age Related ◽  
Age Related Hearing Loss

Conditions affecting the inner ear are delineated. Sensorineural hearing loss and its aetiologies are explored in reference to age-related hearing loss, noise-induced hearing loss, syndromic problems, and auditory neuropathy spectrum disorder. Causes of vertigo related to peripheral vestibular dysfunction are discussed, including vestibular migraine. Management of temporal bone fractures and their sequelae are explored. Methods of hearing rehabilitation are described.

A metal–organic framework based inner ear delivery system for the treatment of noise-induced hearing loss

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16359-16365
Author(s):  
Xiaoxiang Xu ◽  
Kun Lin ◽  
Yanzhi Wang ◽  
Kai Xu ◽  
Yu Sun ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Side Effects ◽  
Inner Ear ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Noise Induced Hearing Loss ◽  
Zeolitic Imidazolate Framework ◽  
Good Protection ◽  
Metal Organic ◽  
Organic Framework

A novel zeolitic imidazolate framework (ZIF)-based system for methylprednisolone (MP) delivery in the inner ear was developed and exhibited good protection of mice from noise and low side effects.

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