scholarly journals DisruptingTP53 in mouse models of human cancers

2003 ◽  
Vol 21 (3) ◽  
pp. 321-326 ◽  
Author(s):  
John M. Parant ◽  
Guillermina Lozano
Keyword(s):  
Mouse Models ◽  
Human Cancers

scholarly journals How Genetically Engineered Mouse Tumor Models Provide Insights Into Human Cancers

2011 ◽  
Vol 29 (16) ◽  
pp. 2273-2281 ◽  
Author(s):  
Katerina Politi ◽  
William Pao
Keyword(s):  
Mouse Models ◽  
Cancer Biology ◽  
Human Cancer ◽  
Genetically Engineered ◽  
Mouse Tumor ◽  
Tumor Models ◽  
Genetically Engineered Mouse Models ◽  
Human Cancers ◽  
Chemically Induced

Genetically engineered mouse models (GEMMs) of human cancer were first created nearly 30 years ago. These early transgenic models demonstrated that mouse cells could be transformed in vivo by expression of an oncogene. A new field emerged, dedicated to generating and using mouse models of human cancer to address a wide variety of questions in cancer biology. The aim of this review is to highlight the contributions of mouse models to the diagnosis and treatment of human cancers. Because of the breadth of the topic, we have selected representative examples of how GEMMs are clinically relevant rather than provided an exhaustive list of experiments. Today, as detailed here, sophisticated mouse models are being created to study many aspects of cancer biology, including but not limited to mechanisms of sensitivity and resistance to drug treatment, oncogene cooperation, early detection, and metastasis. Alternatives to GEMMs, such as chemically induced or spontaneous tumor models, are not discussed in this review.

scholarly journals Report from the Fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop

2011 ◽  
Vol 13 (7) ◽  
pp. 692-699 ◽  
Author(s):  
D. H. Gutmann ◽  
C. D. Stiles ◽  
S. W. Lowe ◽  
G. E. Bollag ◽  
F. B. Furnari ◽  
...  
Keyword(s):  
Nervous System ◽  
Mouse Models ◽  
National Cancer Institute ◽  
Nervous System Tumors ◽  
Human Cancers

scholarly journals Esophageal Cancer: Insights from Mouse Models

2015 ◽  
Vol 8s1 ◽  
pp. CGM.S21218 ◽  
Author(s):  
Marie-Pier Tétreault
Keyword(s):  
Esophageal Cancer ◽  
Mouse Models ◽  
Molecular Mechanisms ◽  
Human Subjects ◽  
Surgical Techniques ◽  
Therapeutic Strategies ◽  
Human Cancers ◽  
Genetic Modifications ◽  
Wide Range ◽  
Gestation Time

Esophageal cancer is the eighth leading cause of cancer and the sixth most common cause of cancer-related death worldwide. Despite recent advances in the development of surgical techniques in combination with the use of radiotherapy and chemotherapy, the prognosis for esophageal cancer remains poor. The cellular and molecular mechanisms that drive the pathogenesis of esophageal cancer are still poorly understood. Hence, understanding these mechanisms is crucial to improving outcomes for patients with esophageal cancer. Mouse models constitute valuable tools for modeling human cancers and for the preclinical testing of therapeutic strategies in a manner not possible in human subjects. Mice are excellent models for studying human cancers because they are similar to humans at the physiological and molecular levels and because they have a shorter gestation time and life cycle. Moreover, a wide range of well-developed technologies for introducing genetic modifications into mice are currently available. In this review, we describe how different mouse models are used to study esophageal cancer.

scholarly journals SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers

2017 ◽  
Vol 46 (D1) ◽  
pp. D1011-D1017 ◽  
Author(s):  
Justin Y Newberg ◽  
Karen M Mann ◽  
Michael B Mann ◽  
Nancy A Jenkins ◽  
Neal G Copeland
Keyword(s):  
Mouse Models ◽  
Gene Discovery ◽  
Sleeping Beauty ◽  
Cancer Driver ◽  
Human Cancers

scholarly journals Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

2006 ◽  
Vol 203 (5) ◽  
pp. 1143-1145 ◽  
Author(s):  
Steven E. Artandi
Keyword(s):  
Disease Virus ◽  
Mouse Models ◽  
Marek's Disease Virus ◽  
Tumor Formation ◽  
Human Cells ◽  
Marek's Disease ◽  
Cancer Development ◽  
Telomerase Rna ◽  
Marek’S Disease Virus ◽  
Human Cancers

Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models. New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation. These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.

scholarly journals Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee

2013 ◽  
Vol 73 (9) ◽  
pp. 2718-2736 ◽  
Author(s):  
Michael Ittmann ◽  
Jiaoti Huang ◽  
Enrico Radaelli ◽  
Philip Martin ◽  
Sabina Signoretti ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
New York ◽  
Animal Models ◽  
Mouse Models ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Cancers ◽  
Consensus Report
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