scholarly journals Report from the Fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop

2011 ◽  
Vol 13 (7) ◽  
pp. 692-699 ◽  
Author(s):  
D. H. Gutmann ◽  
C. D. Stiles ◽  
S. W. Lowe ◽  
G. E. Bollag ◽  
F. B. Furnari ◽  
...  
Keyword(s):  
Nervous System ◽  
Mouse Models ◽  
National Cancer Institute ◽  
Nervous System Tumors ◽  
Human Cancers

scholarly journals Rethinking Brain Tumors: The Fourth Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop

2008 ◽  
Vol 68 (14) ◽  
pp. 5508-5511 ◽  
Author(s):  
Karlyne M. Reilly ◽  
Joshua B. Rubin ◽  
Richard J. Gilbertson ◽  
Joel R. Garbow ◽  
Martine F. Roussel ◽  
...  
Keyword(s):  
Nervous System ◽  
Brain Tumors ◽  
Mouse Models ◽  
Nervous System Tumors ◽  
Human Cancers

scholarly journals Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors

2006 ◽  
Vol 66 (1) ◽  
pp. 10-13 ◽  
Author(s):  
David H. Gutmann ◽  
Elizabeth A. Maher ◽  
Terry Van Dyke
Keyword(s):  
Nervous System ◽  
Mouse Models ◽  
Nervous System Tumors ◽  
Human Cancers

Neonatal Central Nervous System Tumors

2021 ◽  
Vol 48 (1) ◽  
pp. 35-51
Author(s):  
Shubin Shahab ◽  
Jason Fangusaro
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors

scholarly journals The Function of Selenium in Central Nervous System: Lessons from MsrB1 Knockout Mouse Models

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1372
Author(s):  
Tengrui Shi ◽  
Jianxi Song ◽  
Guanying You ◽  
Yujie Yang ◽  
Qiong Liu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Mouse Models ◽  
Knockout Mouse ◽  
Methionine Sulfoxide ◽  
Methionine Sulfoxide Reductase ◽  
Knockout Mouse Model ◽  
The Central Nervous System

MsrB1 used to be named selenoprotein R, for it was first identified as a selenocysteine containing protein by searching for the selenocysteine insert sequence (SECIS) in the human genome. Later, it was found that MsrB1 is homologous to PilB in Neisseria gonorrhoeae, which is a methionine sulfoxide reductase (Msr), specifically reducing L-methionine sulfoxide (L-Met-O) in proteins. In humans and mice, four members constitute the Msr family, which are MsrA, MsrB1, MsrB2, and MsrB3. MsrA can reduce free or protein-containing L-Met-O (S), whereas MsrBs can only function on the L-Met-O (R) epimer in proteins. Though there are isomerases existent that could transfer L-Met-O (S) to L-Met-O (R) and vice-versa, the loss of Msr individually results in different phenotypes in mice models. These observations indicate that the function of one Msr cannot be totally complemented by another. Among the mammalian Msrs, MsrB1 is the only selenocysteine-containing protein, and we recently found that loss of MsrB1 perturbs the synaptic plasticity in mice, along with the astrogliosis in their brains. In this review, we summarized the effects resulting from Msr deficiency and the bioactivity of selenium in the central nervous system, especially those that we learned from the MsrB1 knockout mouse model. We hope it will be helpful in better understanding how the trace element selenium participates in the reduction of L-Met-O and becomes involved in neurobiology.

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