Developing buoyant convection in vertical porous annuli with unheated entry and exit

Heat Transfer ◽  
2020 ◽  
Vol 49 (5) ◽  
pp. 2551-2576 ◽  
Author(s):  
Girish N ◽  
M. Sankar ◽  
O. D. Makinde
Keyword(s):  
Entry And Exit ◽  
Buoyant Convection

Business processes in the insurance company: The method of operation through separating the key areas of activities

2020 ◽  
Vol 23 (11) ◽  
pp. 1269-1290
Author(s):  
A.A. Turgaeva
Keyword(s):  
Business Process ◽  
Business Processes ◽  
Systems Approach ◽  
Insurance Company ◽  
Entry And Exit ◽  
Control Procedures ◽  
Selection Of

Subject. This article analyzes the business processes in the insurance company, using the method of their operation with the selection of key areas of activity. Objectives. The article aims to describe certain business processes in insurance, highlighting participants, lines of activity, and the sequence of procedures. It analyzes the business process Settlement of Losses, which is one of the significant business processes in the insurance company. Methods. For the study, I used the methods of induction and deduction, analogy, and the systems approach. Results. Based on the analysis and description of business processes in the insurance company and the identification of key elements and steps in terms of the effectiveness of decisions, the article identifies the checkpoints of Entry and Exit, activity direction, and resources of the Settlement of Losses process. Conclusions. The application of the categories that split business processes makes it possible to develop step regulation for all processes and acceptable control procedures for different operations. The presented checkpoints at different steps of the business process will help identify weaknesses and eliminate them by re-checking the point.

Computer-aided structural and molecular insights into the mechanisms by which Pseudouridimycin (PUM) disrupts cleft extension in bacterial RNA polymerase to block DNA entry and exit

2020 ◽  
Vol 17 ◽  
Author(s):  
Ali H. Rabbad ◽  
Fisayo A. Olotu ◽  
Mahmoud E. Soliman
Keyword(s):  
Rna Polymerase ◽  
Bacterial Infections ◽  
Entry And Exit ◽  
Dynamic Binding ◽  
Binding Behavior ◽  
Bacterial Rna ◽  
Nucleotide Addition ◽  
Switch Regions ◽  
Cleft Extension ◽  
Key Residues

Background: The ability of Pseudouridimycin (PUM) to occupy the nucleotide addition site of bacterial RNA Polymerase (RNAP) underlies its inhibitory potency as previously reported. PUM has gained high research interest as a broad-spectrum nucleoside analog that has demonstrated exciting potentials in treating drug-resistant bacterial infections. Objective: Herein, we identified, for the first time, a novel complementary mechanism by which PUM elicits its inhibitory effects on bacterial RNAP. Methods: The dynamic binding behavior of PUM to bacterial RNAP was studied using various dynamic analyses approaches. Results and Discussion: Findings revealed that in addition to occupying the nucleotide addition site, PUM also interrupts the unimpeded entry and exit of DNA by reducing the mechanistic extension of the RNAP cleft and perturbing the primary conformations of the switch regions. Moreover, PUM binding reduced the distances between key residues in the β and β’ subunits that extend to accommodate the DNA. Conclusion: This study’s findings present structural insights that would contribute to the structure-based design of potent and selective PUM inhibitors.

Delegation and Control Revisited

2018 ◽  
Author(s):  
Dan Honig
Keyword(s):  
Foreign Aid ◽  
International Development ◽  
Local Knowledge ◽  
Entry And Exit ◽  
Country Ownership ◽  
Development Organization ◽  
Workplace Experience ◽  
And Control ◽  
The Relationship

This chapter traces the relationship between political authorizing environments, international development organization (IDO) management, and IDO field agents, drawing on the empirics presented in chapters 6 and 7. It digs into the experience of working for USAID as compared to DFID. It also extends the discussion of delegation to implementing contractors and brings this book’s theorizing of Navigation by Judgment into conversation with other foreign aid solutions aimed at incorporating local knowledge, such as establishing country offices or ensuring projects have country ownership. This chapter connects Part II’s empirics more tightly to the mechanisms theorized in Part I , particularly the role of authorizing environment insecurity and the need to “manage up” (Chapter 4) and their implications for the workplace experience of agents (Chapter 3) and the entry and exit of personnel.

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