scholarly journals Long‐term effects of two 24‐hour moisturizing products on skin barrier structure and function: A biometric and molecular study

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Aniseh Samadi ◽  
Saman Ahmad Nasrollahi ◽  
Mahmoud Nateghi Rostami ◽  
Zahra Rezagholi ◽  
Farideh Abolghasemi ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Molecular Study ◽  
Structure And Function ◽  
Barrier Structure ◽  
Long Term Effects ◽  
And Function

Abstract P138: Long-term Effects Of Severe Caloric Restriction To The Heart Function

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Aline M De Souza ◽  
Jonathas Almeida ◽  
Nataliia Shults ◽  
Hong Ji ◽  
Kathryn Sandberg
Keyword(s):  
Cardiovascular Disease ◽  
Caloric Restriction ◽  
Heart Function ◽  
Left Ventricular ◽  
Structure And Function ◽  
Long Term Effects ◽  
Isolated Hearts ◽  
Ad Libitum ◽  
And Function

Severe caloric restriction (sCR) increases the risk for acute cardiovascular disease. Less understood are the long-term effects on cardiovascular disease risk after the sCR period has ended. We investigated the effects of sCR on heart structure and function months after refeeding (sCR-Refed). Female Fischer rats (3-months-old) were maintained on (CT) ad libitum or a 60% caloric restricted diet for 2 weeks. Thereafter, all rats received ad libitum chow for 3 months and they were analyzed by precision ultrasound to assess their heart function. After imaging, the animals were sacrificed and the hearts were subjected to ischemia-reperfusion (I/R) using a Langendorff preparation. After 2 weeks of sCR, rats lost 15% of their initial body weight (BW) [% (100*(Final-Initial/Initial)): CT, 1.5±0.8 vs sCR, -15.4±1.1; p<0.001;n=8]. After 3 months of refeeding, there was no detectable difference in BW between CT and sFR-Refed groups. Isolated hearts from the sCR-Refed rats exhibited worse myocardial pathology after I/R compared to CT rats. The parallel orientation of myofibers and striations normally present in cardiomyocytes was lost in sCR-Refed rats. Further analysis revealed uneven blood-filling of the microcirculatory vessels and prominent interstitial edema of the myocardium. Hearts from sCR-Refed rats had more atrophied cardiomyocytes than CT [Atrophied/Total (%): CT, 0.2±0.1 vs sCR-Refed, 50.6±1.1; p<0.001; n=5]. The number of arrhythmic events during a 30 min ischemic interval in isolated hearts doubled after 2 weeks on the sCR diet ( data not shown ) and remained doubled 3 months later [Arrhythmias (% of time): CT, 34±8 vs sCR-Refed, 68±9; p=0.02; n=8]. Ultrasound imaging showed no difference in stroke volume, coronary perfusion pressure and left ventricular mass. However, the thickness of the left ventricular posterior wall was significantly reduced in sCR-Refed rats [(mm): CT, 2.55 ±0.03 vs sCR-Refed, 2.10±0.04; p=0.002; n=4]. These findings indicate heart structure and function remained damaged months after the sCR period ended and BW was restored. These studies have adverse cardiovascular risk implications for who are subjected either voluntarily (crash diets) or involuntarily (very low food security) to periods of inadequate caloric intake.

Effects of Hydroxydecine® (10-hydroxy-2-decenoic acid) on skin barrier structure and function in vitro and clinical efficacy in the treatment of UV-induced xerosis

2011 ◽  
Vol 21 (6) ◽  
pp. 906-915 ◽  
Author(s):  
Hélène Duplan ◽  
Emmanuel Questel ◽  
Hélène Hernandez-Pigeon ◽  
Marie Florence Galliano ◽  
Antony Caruana ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Skin Barrier ◽  
Structure And Function ◽  
Barrier Structure ◽  
Decenoic Acid ◽  
And Function

scholarly journals The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

2016 ◽  
Vol 29 (3) ◽  
pp. 135-147 ◽  
Author(s):  
Simon G. Danby ◽  
Kirsty Brown ◽  
Tim Higgs-Bayliss ◽  
John Chittock ◽  
Lujain Albenali ◽  
...  
Keyword(s):  
Older People ◽  
Skin Barrier ◽  
Structure And Function ◽  
Barrier Structure ◽  
Dry Skin ◽  
And Function

scholarly journals Long-term effects of losartan on structure and function of the thoracic aorta in a mouse model of Marfan syndrome

2009 ◽  
Vol 158 (6) ◽  
pp. 1503-1512 ◽  
Author(s):  
HH Clarice Yang ◽  
Jong Moo Kim ◽  
Elliott Chum ◽  
Cornelis van Breemen ◽  
Ada WY Chung
Keyword(s):  
Mouse Model ◽  
Marfan Syndrome ◽  
Thoracic Aorta ◽  
Structure And Function ◽  
Long Term Effects ◽  
And Function
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