CHANGES IN CONCENTRATION OF SERUM FREE LIGHT CHAINS OF IMMUNOGLOBULINS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AS A FACTOR FOR EVALUATING CHEMOTHERAPY EFFECTIVENESS

2019 ◽  
Vol 37 ◽  
pp. 376-377
Author(s):  
I. Kogarko ◽  
A. Golenkov ◽  
E. Kataeva ◽  
T. Mitina ◽  
Y. Chuksina ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

scholarly journals Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Katerina Sarris ◽  
Dimitrios Maltezas ◽  
Efstathios Koulieris ◽  
Vassiliki Bartzis ◽  
Tatiana Tzenou ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Lymphocytic Leukemia ◽  
Light Chains ◽  
Free Light Chains ◽  
Prognostic Implication ◽  
Time To Treatment ◽  
Serum Free ◽  
Binet Stage ◽  
Serum Free Light Chains

Background. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients.Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients’ series.Patients and Methods. We studied 143 CLL patients of which 18 were symptomatic and needed treatment, while 37 became symptomatic during follow-up. Seventy-two percent, 18%, and 10% were in Binet stage A, B and C, respectively. Median patients’ followup was 32 months (range 4–228).Results. Increased involved (restricted) sFLC (iFLC) was found in 42% of patients, while the summated FLC-kappa plus FLC-lambda was above 60 mg/dL in 14%. Increased sFLC values as well as those of summated FLC above 60 were related to shorter time to treatment (P=0.0005andP=0.000003, resp.) and overall survival (P=0.05andP=0.003, resp.). They also correlated withβ2-microglobulin (P=0.009andP=0.03, resp.), serum albumin (P=0.009for summated sFLC), hemoglobin (P<0.001), abnormal LDH (P=0.037andP=0.001, resp.), Binet stage (P<0.05) and with the presence of beta symptoms (P=0.004for summated sFLC).Conclusion. We confirmed the prognostic significance of sFLC in CLL regarding both time to treatment and survival and showed their relationship with other parameters.

scholarly journals Serum free light chains

Pathology ◽  
2021 ◽  
Vol 53 ◽  
pp. S4
Author(s):  
Karl W. Baumgart
Keyword(s):  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

Measurement of Serum Free Light Chains in AL Amyloidosis

2004 ◽  
pp. 154-156
Author(s):  
H.D. Carr-Smith ◽  
R. Abraham ◽  
G.P. Mead ◽  
H. Goodman ◽  
P. Hawkins ◽  
...  
Keyword(s):  
Light Chains ◽  
Al Amyloidosis ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

Response to article by Caponi et al. about serum free light chains

2018 ◽  
Vol 57 (2) ◽  
pp. e1-e2 ◽  
Author(s):  
Jillian R. Tate ◽  
Carmel Hawley ◽  
Peter Mollee
Keyword(s):  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

Serum free light chains: Prospective evaluation of a new ELISA assay

2019 ◽  
Vol 493 ◽  
pp. S55
Author(s):  
J. Pekar ◽  
B. Lopez ◽  
S. Schraen ◽  
B. Onraed
Keyword(s):  
Light Chains ◽  
Elisa Assay ◽  
Prospective Evaluation ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains
Sign in / Sign up

Export Citation Format

Share Document