Role of serum free light chains in predicting HIV-associated non-Hodgkin lymphoma and Hodgkin's lymphoma and its correlation with antiretroviral therapy

2012 ◽  
Vol 87 (8) ◽  
pp. 749-753 ◽  
Author(s):  
Michele Bibas ◽  
Maria Paola Trotta ◽  
Alessandro Cozzi-Lepri ◽  
Patrizia Lorenzini ◽  
Carmela Pinnetti ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hodgkin Lymphoma ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Non Hodgkin Lymphoma ◽  
Serum Free Light Chains

scholarly journals The Importance of Free Light Chains of Immunoglobulins Determination in Serum

2007 ◽  
Vol 26 (4) ◽  
pp. 269-273
Author(s):  
Velibor Čabarkapa ◽  
Zoran Stošić ◽  
Mirjana Đerić ◽  
Ljiljana Vučurević-Ristić ◽  
Mirjana Drljača
Keyword(s):  
Diagnostic Marker ◽  
Protein Electrophoresis ◽  
Light Chains ◽  
Malignant Diseases ◽  
Free Light Chains ◽  
Serum Free ◽  
M 12 ◽  
Serum Free Light Chains ◽  
Bence Jones Proteinuria

The Importance of Free Light Chains of Immunoglobulins Determination in SerumFor many years, Bence Jones proteinuria has been an important diagnostic marker for multiple myeloma. Relatively new serum tests for free kappa and free lambda light chains of immunoglobulins reflect the production of free light chains more accurately than urine tests. In this study, we examined the value of serum free light chains measurement in the diagnosis of some neoplastic diseases and the discrepance between the findings of serum protein electrophoresis and serum free light chains. Thirty one patients (f=19, m=12) were included in the study, most of them with blood malignant diseases. The results show that in six patients with normal gamma and beta electrophoresis fractions there are abnormal levels of free light chains and/or an abnormal κ/LD ratio. In 20 patients we found an abnormal κ/LD ratio, and in 21 patients we found an abnormal κ or LD level, or both. The obtained results show the important role of serum free light chains determination in identifying patients with monoclonal gammopathies.

The Predictive Role of Circulating Serum Free Light Chains (sFLC) in HIV-Associated Non Hodgkin's Lymphoma (NHL) and Hodgkin's Disease (HD) and Its Correlation with Effective Combined Antiretroviral Treatment (cART)

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3089-3089
Author(s):  
Michele Bibas ◽  
Maria Paola Trotta ◽  
Patrizia Lorenzini ◽  
Alessandro Cozzi-Lepri ◽  
M. Borderi ◽  
...  
Keyword(s):  
B Cell ◽  
Light Chains ◽  
Dependent Manner ◽  
Normal Range ◽  
Free Light Chains ◽  
Serum Free ◽  
Risk Of Death ◽  
Increased Risk ◽  
Serum Free Light Chains

Abstract Abstract 3089 Background: In the last years great interest has been devolved to evaluate the role of B-cell dysfunction in the etiology of AIDS-related Non-Hodgkin Lymphoma (NHL) by directly measuring serum-based markers of B-cell stimulation. Serum free light chains (sFLC) has been proposed as sensitive markers of AIDS-related NHL. Role of sFLC in HL in HIV-infected people has not been completely assessed, and the influence of cART on this marker remains unknown. We evaluated the prognostic value of sFLC to predict the risk of AIDS-related NHL and HD in HIV-infected patients. Methods: The design was a case-control study nested within ICONA. Of 6500 participants enrolled from 1997 to 2007, 86 patients with incident lymphoma were proposed as cases. Information on cancers was obtained prospectively by using medical record review. 46 of 86 patients with lymphoma (NHL =30; HD=16) were included as cases (n=46) because they had no other co-morbidity and a plasma sample available stored before diagnosis of lymphoma. A total of 138 sample-cases were matched 1:1 to lymphoma-free sample-controls (matching for sex, age, distance from diagnosis/selection stratified as 0–2, 2–5, and >5 years). All samples were assessed for quantitative levels of sFLC. Serum or plasma samples stored at -80C were analyzed for quantitative levels of κ and λ sFLC in the Chemistry Laboratory of INMI “L. Spallanzani” in Rome. sFCL concentrations were determined by using the quantitative FLC assay (Freelite; The Binding Site, Birmingham, UK) performed on a Dare-Behring BNII Nephelometer. The assay separately measures κ sFLC (normal range, 0.37 to 1.94 mg/dl) and λ sFLC (normal range, 0.57 to 2.63 mg/dl). A conditional logistic regression was used to identify predictors of lymphoma. Result: The κ and λ and κ+λ sFLC values were significantly higher in patient with lymphoma than in controls (p=0.008, 0.002, 0.003 respectively). In multivariate analysis sFLC strongly predicted the risk of lymphoma in a dose dependent manner, independently from CD4 count and effective therapy. Longer duration with a suppressed viremia was independently associated with a lower risk of lymphoma. Same results were found for the subgroup of subjects with HD and that with NHD. Conclusion: Elevated sFLC was a strong and sensitive marker of risk of development of NHL and HD in HIV-infected individuals. Decreasing lymphoma risk was independently associated with increasing cumulative time spent with HIV viremia < 400 cp/ml. This could reflect the detrimental effects on immune status associated with absence of treatment or incompletely effective HAART or other disturbances of immune function such as chronic immune activation and the direct effects of HIV on B-cells. Subjects with sFLC >50% of normal threshold at most recent samples (0-3 years) showed an increased risk of lymphoma than subjects with the same levels of sFLC at an earlier sample. Our results seems indicate a weak association between elevated sFLC and risk of death/relapse among subjects with lymphomas. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Elevated serum free light chains are associated with inferior event free and overall survival in Hodgkin lymphoma

2011 ◽  
Vol 86 (12) ◽  
pp. 998-1000 ◽  
Author(s):  
Carrie A. Thompson ◽  
Matthew J. Maurer ◽  
James R. Cerhan ◽  
Jerry A. Katzmann ◽  
Stephen M. Ansell ◽  
...  
Keyword(s):  
Overall Survival ◽  
Hodgkin Lymphoma ◽  
Elevated Serum ◽  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains

scholarly journals Serum free light chains

Pathology ◽  
2021 ◽  
Vol 53 ◽  
pp. S4
Author(s):  
Karl W. Baumgart
Keyword(s):  
Light Chains ◽  
Free Light Chains ◽  
Serum Free ◽  
Serum Free Light Chains
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