Design and Synthesis of Potent Macrocyclic Benzolactam Growth Hormone Secretagogues

1997 ◽  
Vol 80 (4) ◽  
pp. 1244-1259 ◽  
Author(s):  
Robert J. De Vita ◽  
Alison J. Frontier ◽  
William R. Schoen ◽  
Matthew J. Wyvratt ◽  
Michael H. Fisher ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Secretagogues ◽  
Design And Synthesis

The design and synthesis of orally active short duration spiroindane growth hormone secretagogues

1997 ◽  
Vol 7 (17) ◽  
pp. 2319-2324 ◽  
Author(s):  
James R. Tata ◽  
Zhijian Lu ◽  
Thomas M. Jacks ◽  
Klaus D. Schleim ◽  
Kang Cheng ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Duration ◽  
Growth Hormone Secretagogues ◽  
Design And Synthesis ◽  
Orally Active

scholarly journals The synthesis of a small library of prospective growth hormone secretagogues

1999 ◽  
Vol 64 (10) ◽  
pp. 571-576
Author(s):  
Vojislav Pejovic ◽  
Vukic Soskic ◽  
Jelena Joksimovic
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Combinatorial Chemistry ◽  
Methodological Approach ◽  
Rabbit Antiserum ◽  
Building Blocks ◽  
Growth Hormone Secretagogues ◽  
Growth Hormone Secretagogue ◽  
Design And Synthesis ◽  
Polyclonal Rabbit Antiserum

Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues. For this purpose seven building blocks of tBoc- and Fmoc-protected amino acids was used. In this way, a small, tripeptoid library on polyethylene glycolmonomethyl ether 5000 (PEG 5000) as a soluble support was obtained. The library was screened by a new, simple system, based on polyclonal rabbit antiserum raised against "GH secretagogue pharmacophore" of a known growth hormone secretagogue GHRP-6 (Hexarelin?) and the most promising GH secretagogue candidate was selected.

Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues

2007 ◽  
Vol 17 (21) ◽  
pp. 5928-5933 ◽  
Author(s):  
Andrés S. Hernández ◽  
Peter T.W. Cheng ◽  
Christa M. Musial ◽  
Stephen G. Swartz ◽  
Rocco J. George ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Secretagogues ◽  
Structure Activity

Growth hormone secretagogues: recent advances and applications

1999 ◽  
Vol 4 (11) ◽  
pp. 497-506 ◽  
Author(s):  
Michael Ankersen ◽  
Thomas K. Hansen ◽  
Ian Ahnfelt-Rønne ◽  
Anne M. Kappelgaard
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Secretagogues ◽  
Recent Advances

Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart

2003 ◽  
Vol 98 (6) ◽  
pp. 401-405 ◽  
Author(s):  
Sabina Frascarelli ◽  
Sandra Ghelardoni ◽  
Simonetta Ronca-Testoni ◽  
Riccardo Zucchi
Keyword(s):  
Growth Hormone ◽  
Rat Heart ◽  
Growth Hormone Secretagogues ◽  
Synthetic Growth

ChemInform Abstract: Benzolactam Growth Hormone Secretagogues: Replacement of the C-3 Amide Bond in L-692,429.

ChemInform ◽  
2010 ◽  
Vol 28 (24) ◽  
pp. no-no
Author(s):  
H. O. OK ◽  
J. L. SZUMILOSKI ◽  
G. A. DOLDOURAS ◽  
W. R. SCHOEN ◽  
K. CHENG ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Amide Bond ◽  
Growth Hormone Secretagogues

Benzolactam growth hormone secretagogues: Replacement of the C-3 amide bond in L-692,429

1996 ◽  
Vol 6 (24) ◽  
pp. 3051-3056 ◽  
Author(s):  
Hyun O Ok ◽  
John L Szumiloski ◽  
George A Doldouras ◽  
William R Schoen ◽  
Kang Cheng ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Amide Bond ◽  
Growth Hormone Secretagogues
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