Some implications of postnatal hippocampal development

Hippocampus ◽  
2021 ◽  
Author(s):  
Lynn Nadel
Keyword(s):  
Hippocampal Development

ISDN2014_0057: Inhibition of GSK3‐beta rescues hippocampal development in a knockout mouse model of CDKL5 encephalopathy

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 12-13
Author(s):  
Claudia Fuchs ◽  
Rocchina Viggiano ◽  
Stefania Trazzi ◽  
Marianna De Franceschi ◽  
Renata Bartesaghi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knockout Mouse ◽  
Knockout Mouse Model ◽  
Hippocampal Development

Early specification and autonomous development of cortical fields in the mouse hippocampus

Development ◽  
1997 ◽  
Vol 124 (24) ◽  
pp. 4959-4970 ◽  
Author(s):  
S. Tole ◽  
C. Christian ◽  
E.A. Grove
Keyword(s):  
Gene Expression ◽  
Slice Culture ◽  
Field Development ◽  
Cortical Areas ◽  
Hippocampal Field ◽  
Mouse Hippocampus ◽  
Hippocampal Development ◽  
Autonomous Development ◽  
The Brain ◽  
Development Proceeds

Studies of the specification of distinct areas in the developing cerebral cortex have until now focused mainly on neocortex. We demonstrate that the hippocampus, an archicortical structure, offers an elegant, alternative system in which to explore cortical area specification. Individual hippocampal areas, called CA fields, display striking molecular differences in maturity. We use these distinct patterns of gene expression as markers of CA field identity, and show that the two major hippocampal fields, CA1 and CA3, are specified early in hippocampal development, during the period of neurogenesis. Two field-specific markers display consistent patterns of expression from the embryo to the adult. Presumptive CA1 and CA3 fields (Pca1, Pca3) can therefore be identified between embryonic days 14.5 and 15.5 in the mouse, a week before the fields are morphologically distinct. No other individual cortical areas have been detected by gene expression as early in development. Indeed, other features that distinguish between the CA fields appear after birth, indicating that mature CA field identity is acquired over at least 3 weeks. To determine if Pca1 and Pca3 are already specified to acquire mature CA field identities, the embryonic fields were isolated from further potential specification cues by maintaining them in slice culture. CA field development proceeds in slices of the entire embryonic hippocampus. More strikingly, slices restricted to Pca1 or Pca3 alone also develop appropriate mature features of CA1 or CA3. Pca1 and Pca3 are therefore able to develop complex characteristics of mature CA field identity autonomously, that is, without contact or innervation from other fields or other parts of the brain. Because Pca1 and Pca3 can be identified before major afferents grow into the hippocampus, innervation may also be unnecessary for the initial division of the hippocampus into separate fields. Providing a clue to the source of the true specifying signals, the earliest field markers appear first at the poles of the hippocampus, then progress inwards. General hippocampal development does not follow this pronounced pattern. We suggest that the sources of signals that specify hippocampal field identity lie close to the hippocampal poles, and that the signals operate first on cells at the poles, then move inwards.

scholarly journals Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mary Youssef ◽  
Piray Atsak ◽  
Jovani Cardenas ◽  
Stylianos Kosmidis ◽  
E. David Leonardo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Adult Stem Cell ◽  
Cell Pool ◽  
Hippocampal Development ◽  
Stem Cell Pool

scholarly journals Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function

2017 ◽  
Vol 76 ◽  
pp. 206-217 ◽  
Author(s):  
Tuong-Vi Nguyen ◽  
Jimin Lew ◽  
Matthew D. Albaugh ◽  
Kelly N. Botteron ◽  
James J. Hudziak ◽  
...  
Keyword(s):  
Executive Function ◽  
Hippocampal Development

scholarly journals Neuronal NLRC5 regulates MHC class I expression in Neuro‐2a cells and also during hippocampal development

2019 ◽  
Vol 152 (2) ◽  
pp. 182-194 ◽  
Author(s):  
Ping Li ◽  
Yuqing Shen ◽  
Pengfei Cui ◽  
Yue Hu ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Hippocampal Development
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