ISDN2014_0057: Inhibition of GSK3‐beta rescues hippocampal development in a knockout mouse model of CDKL5 encephalopathy

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 12-13
Author(s):  
Claudia Fuchs ◽  
Rocchina Viggiano ◽  
Stefania Trazzi ◽  
Marianna De Franceschi ◽  
Renata Bartesaghi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knockout Mouse ◽  
Knockout Mouse Model ◽  
Hippocampal Development

scholarly journals DNase1 Does Not Appear to Play a Major Role in the Fragmentation of Plasma DNA in a Knockout Mouse Model

2018 ◽  
Vol 64 (2) ◽  
pp. 406-408 ◽  
Author(s):  
Timothy H T Cheng ◽  
Kathy O Lui ◽  
Xianlu Laura Peng ◽  
Suk Hang Cheng ◽  
Peiyong Jiang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knockout Mouse ◽  
Plasma Dna ◽  
Knockout Mouse Model

scholarly journals The Function of Selenium in Central Nervous System: Lessons from MsrB1 Knockout Mouse Models

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1372
Author(s):  
Tengrui Shi ◽  
Jianxi Song ◽  
Guanying You ◽  
Yujie Yang ◽  
Qiong Liu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Mouse Models ◽  
Knockout Mouse ◽  
Methionine Sulfoxide ◽  
Methionine Sulfoxide Reductase ◽  
Knockout Mouse Model ◽  
The Central Nervous System

MsrB1 used to be named selenoprotein R, for it was first identified as a selenocysteine containing protein by searching for the selenocysteine insert sequence (SECIS) in the human genome. Later, it was found that MsrB1 is homologous to PilB in Neisseria gonorrhoeae, which is a methionine sulfoxide reductase (Msr), specifically reducing L-methionine sulfoxide (L-Met-O) in proteins. In humans and mice, four members constitute the Msr family, which are MsrA, MsrB1, MsrB2, and MsrB3. MsrA can reduce free or protein-containing L-Met-O (S), whereas MsrBs can only function on the L-Met-O (R) epimer in proteins. Though there are isomerases existent that could transfer L-Met-O (S) to L-Met-O (R) and vice-versa, the loss of Msr individually results in different phenotypes in mice models. These observations indicate that the function of one Msr cannot be totally complemented by another. Among the mammalian Msrs, MsrB1 is the only selenocysteine-containing protein, and we recently found that loss of MsrB1 perturbs the synaptic plasticity in mice, along with the astrogliosis in their brains. In this review, we summarized the effects resulting from Msr deficiency and the bioactivity of selenium in the central nervous system, especially those that we learned from the MsrB1 knockout mouse model. We hope it will be helpful in better understanding how the trace element selenium participates in the reduction of L-Met-O and becomes involved in neurobiology.

scholarly journals The First Knockout Mouse Model of Retinoblastoma

Cell Cycle ◽  
2004 ◽  
Vol 3 (7) ◽  
pp. 950-957 ◽  
Author(s):  
Jiakun Zhang ◽  
Brett Schweers ◽  
Michael A. Dyer
Keyword(s):  
Mouse Model ◽  
Knockout Mouse ◽  
Knockout Mouse Model

WITHDRAWN: Assessment of hematopoietic and neurologic pathophysiology of HCLS1-associated protein X-1 deficiency in a Hax1-knockout mouse model

2014 ◽  
Author(s):  
Emanuele G. Coci ◽  
Nadine Thau-Habermann ◽  
Tobias Maetzig ◽  
Zhixiong Li ◽  
Christoph Klein ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knockout Mouse ◽  
Knockout Mouse Model ◽  
Protein X

scholarly journals A humanized BAC transgenic/knockout mouse model for HbE/β-thalassemia

Genomics ◽  
2006 ◽  
Vol 88 (3) ◽  
pp. 309-315 ◽  
Author(s):  
Duangporn Jamsai ◽  
Faten Zaibak ◽  
Jim Vadolas ◽  
Lucille Voullaire ◽  
Kerry J. Fowler ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knockout Mouse ◽  
Knockout Mouse Model
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