The ratio of posterior–anterior medial temporal lobe volumes predicts source memory performance in healthy young adults

Hippocampus ◽  
2020 ◽  
Vol 30 (11) ◽  
pp. 1209-1227
Author(s):  
Jamie Snytte ◽  
Abdelhalim Elshiekh ◽  
Sivaniya Subramaniapillai ◽  
Lyssa Manning ◽  
Stamatoula Pasvanis ◽  
...  
Keyword(s):  
Young Adults ◽  
Temporal Lobe ◽  
Source Memory ◽  
Medial Temporal Lobe ◽  
Memory Performance ◽  
Posterior Anterior

scholarly journals Early stages of tau pathology and its associations with functional connectivity, atrophy and memory

Brain ◽  
2021 ◽  
Author(s):  
David Berron ◽  
Jacob W Vogel ◽  
Philip S Insel ◽  
Joana B Pereira ◽  
Long Xie ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Entorhinal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Impairment ◽  
Memory Performance ◽  
Hippocampal Atrophy ◽  
Tau Pathology ◽  
Β Amyloid ◽  
With Memory

Abstract In Alzheimer’s disease, postmortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and across regions in the posterior-medial system. Our objective was to study how medial temporal tau is related to functional connectivity, regional atrophy, and memory performance. We included 215 β-amyloid negative cognitively unimpaired, 81 β-amyloid positive cognitively unimpaired and 87 β-amyloid positive individuals with mild cognitive impairment, who each underwent [18]F-RO948 tau and [18]F-flutemetamol amyloid PET imaging, structural T1-MRI and memory assessments as part of the Swedish BioFINDER-2 study. First, event-based modelling revealed that the entorhinal cortex and area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, area 36 and the parahippocampal cortex. In later stages, tau accumulation became abnormal in neocortical temporal and finally parietal brain regions. Second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. Tau load, but not atrophy, in these regions was associated with lower memory performance. Further, tau-related reductions in functional connectivity in critical networks between the medial temporal lobe and regions in the posterior-medial system were associated with this early memory impairment. Finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. In summary, our findings highlight the progression of tau pathology across medial temporal lobe subregions and its disease-stage specific association with memory performance. While tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy.

scholarly journals Medial temporal lobe BOLD activity at rest predicts individual differences in memory ability in healthy young adults

2008 ◽  
Vol 105 (47) ◽  
pp. 18555-18560 ◽  
Author(s):  
G. S. Wig ◽  
S. T. Grafton ◽  
K. E. Demos ◽  
G. L. Wolford ◽  
S. E. Petersen ◽  
...  
Keyword(s):  
Young Adults ◽  
Individual Differences ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Ability

scholarly journals Item memory, source memory, and the medial temporal lobe: Concordant findings from fMRI and memory-impaired patients

2006 ◽  
Vol 103 (24) ◽  
pp. 9351-9356 ◽  
Author(s):  
J. J. Gold ◽  
C. N. Smith ◽  
P. J. Bayley ◽  
Y. Shrager ◽  
J. B. Brewer ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Source Memory ◽  
Medial Temporal Lobe ◽  
Item Memory ◽  
Memory Source

Domain-specific impairment of source memory following a right posterior medial temporal lobe lesion

Hippocampus ◽  
2007 ◽  
Vol 17 (7) ◽  
pp. 505-509 ◽  
Author(s):  
Jan Peters ◽  
Benno Koch ◽  
Michael Schwarz ◽  
Irene Daum
Keyword(s):  
Temporal Lobe ◽  
Source Memory ◽  
Medial Temporal Lobe ◽  
Domain Specific ◽  
Temporal Lobe Lesion

scholarly journals Medial temporal lobe viscoelasticity and relational memory performance

NeuroImage ◽  
2016 ◽  
Vol 132 ◽  
pp. 534-541 ◽  
Author(s):  
Hillary Schwarb ◽  
Curtis L. Johnson ◽  
Matthew D.J. McGarry ◽  
Neal J. Cohen
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Performance ◽  
Relational Memory

Aerobic Fitness Predicts Relational Memory but Not Item Memory Performance in Healthy Young Adults

2014 ◽  
Vol 26 (11) ◽  
pp. 2645-2652 ◽  
Author(s):  
Carol L. Baym ◽  
Naiman A. Khan ◽  
Ari Pence ◽  
Lauren B. Raine ◽  
Charles H. Hillman ◽  
...  
Keyword(s):  
Young Adults ◽  
Eye Movement ◽  
Aerobic Fitness ◽  
Medial Temporal Lobe ◽  
Memory Performance ◽  
Memory Function ◽  
Item Memory ◽  
Relational Memory ◽  
Hippocampal Function ◽  
Beneficial Effects

Health factors such as an active lifestyle and aerobic fitness have long been linked to decreased risk of cardiovascular disease, stroke, and other adverse health outcomes. Only more recently have researchers begun to investigate the relationship between aerobic fitness and memory function. Based on recent findings in behavioral and cognitive neuroscience showing that the hippocampus might be especially sensitive to the effects of exercise and fitness, the current study assessed hippocampal-dependent relational memory and non-hippocampal-dependent item memory in young adults across a range of aerobic fitness levels. Aerobic fitness was assessed using a graded exercise test to measure oxygen consumption during maximal exercise (VO2max), and relational and item memory were assessed using behavioral and eye movement measures. Behavioral results indicated that aerobic fitness was positively correlated with relational memory performance but not item memory performance, suggesting that the beneficial effects of aerobic fitness selectively affect hippocampal function and not that of the surrounding medial temporal lobe cortex. Eye movement results further supported the specificity of this fitness effect to hippocampal function, in that aerobic fitness predicted disproportionate preferential viewing of previously studied relational associations but not of previously viewed items. Potential mechanisms underlying this pattern of results, including neurogenesis, are discussed.

Cognitive impairment and medial temporal lobe structure in young adults with a depressive episode

2018 ◽  
Vol 237 ◽  
pp. 112-117 ◽  
Author(s):  
Markus Donix ◽  
Robert Haussmann ◽  
Franziska Helling ◽  
Anne Zweiniger ◽  
Jan Lange ◽  
...  
Keyword(s):  
Young Adults ◽  
Cognitive Impairment ◽  
Temporal Lobe ◽  
Depressive Episode ◽  
Medial Temporal Lobe
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