Cognitive impairment and medial temporal lobe structure in young adults with a depressive episode

2018 ◽  
Vol 237 ◽  
pp. 112-117 ◽  
Author(s):  
Markus Donix ◽  
Robert Haussmann ◽  
Franziska Helling ◽  
Anne Zweiniger ◽  
Jan Lange ◽  
...  
Keyword(s):  
Young Adults ◽  
Cognitive Impairment ◽  
Temporal Lobe ◽  
Depressive Episode ◽  
Medial Temporal Lobe

Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment

Hippocampus ◽  
2009 ◽  
Vol 19 (2) ◽  
pp. 166-175 ◽  
Author(s):  
Anne M. Jauhiainen ◽  
Maija Pihlajamäki ◽  
Susanna Tervo ◽  
Eini Niskanen ◽  
Heikki Tanila ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

Medial temporal lobe atrophy, but not CSF biomarkers, correlates with cognitive impairment in Alzheimer's disease

2021 ◽  
Vol 429 ◽  
pp. 119059
Author(s):  
Edoardo Barvas ◽  
Chiara Monaldini ◽  
Roberto Frusciante ◽  
Mirco Volpini ◽  
Beatrice Viti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Csf Biomarkers ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy

scholarly journals Increased functional connectivity within medial temporal lobe in mild cognitive impairment

Hippocampus ◽  
2012 ◽  
Vol 23 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Sandhitsu R. Das ◽  
John Pluta ◽  
Lauren Mancuso ◽  
Dasha Kliot ◽  
Sylvia Orozco ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

scholarly journals Medial temporal lobe BOLD activity at rest predicts individual differences in memory ability in healthy young adults

2008 ◽  
Vol 105 (47) ◽  
pp. 18555-18560 ◽  
Author(s):  
G. S. Wig ◽  
S. T. Grafton ◽  
K. E. Demos ◽  
G. L. Wolford ◽  
S. E. Petersen ◽  
...  
Keyword(s):  
Young Adults ◽  
Individual Differences ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Ability

scholarly journals Atrophy and cognitive profiles in older adults with temporal lobe epilepsy are similar to mild cognitive impairment

Brain ◽  
2020 ◽  
Author(s):  
Erik Kaestner ◽  
Anny Reyes ◽  
Austin Chen ◽  
Jun Rao ◽  
Anna Christina Macari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Late Onset ◽  
Amnestic Mild Cognitive Impairment

Abstract Epilepsy incidence and prevalence peaks in older adults yet systematic studies of brain ageing and cognition in older adults with epilepsy remain limited. Here, we characterize patterns of cortical atrophy and cognitive impairment in 73 older adults with temporal lobe epilepsy (>55 years) and compare these patterns to those observed in 70 healthy controls and 79 patients with amnestic mild cognitive impairment, the prodromal stage of Alzheimer’s disease. Patients with temporal lobe epilepsy were recruited from four tertiary epilepsy surgical centres; amnestic mild cognitive impairment and control subjects were obtained from the Alzheimer’s Disease Neuroimaging Initiative database. Whole brain and region of interest analyses were conducted between patient groups and controls, as well as between temporal lobe epilepsy patients with early-onset (age of onset <50 years) and late-onset (>50 years) seizures. Older adults with temporal lobe epilepsy demonstrated a similar pattern and magnitude of medial temporal lobe atrophy to amnestic mild cognitive impairment. Region of interest analyses revealed pronounced medial temporal lobe thinning in both patient groups in bilateral entorhinal, temporal pole, and fusiform regions (all P < 0.05). Patients with temporal lobe epilepsy demonstrated thinner left entorhinal cortex compared to amnestic mild cognitive impairment (P = 0.02). Patients with late-onset temporal lobe epilepsy had a more consistent pattern of cortical thinning than patients with early-onset epilepsy, demonstrating decreased cortical thickness extending into the bilateral fusiform (both P < 0.01). Both temporal lobe epilepsy and amnestic mild cognitive impairment groups showed significant memory and language impairment relative to healthy control subjects. However, despite similar performances in language and memory encoding, patients with amnestic mild cognitive impairment demonstrated poorer delayed memory performances relative to both early and late-onset temporal lobe epilepsy. Medial temporal lobe atrophy and cognitive impairment overlap between older adults with temporal lobe epilepsy and amnestic mild cognitive impairment highlights the risks of growing old with epilepsy. Concerns regarding accelerated ageing and Alzheimer’s disease co-morbidity in older adults with temporal lobe epilepsy suggests an urgent need for translational research aimed at identifying common mechanisms and/or targeting symptoms shared across a broad neurological disease spectrum.

IC-P-094: Medial temporal lobe changes preceding symptom onset of mild cognitive impairment: The BIOCARD Cohort

2013 ◽  
Vol 9 ◽  
pp. P54-P54
Author(s):  
Michael I. Miller ◽  
Laurent Younes ◽  
John Ratnanather ◽  
Timothy Brown ◽  
Mei-Cheng Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Symptom Onset ◽  
Medial Temporal Lobe ◽  
Preceding Symptom

scholarly journals Structural brain changes in hyperthyroid Graves’ disease: protocol for an ongoing longitudinal, case-controlled study in Göteborg, Sweden—the CogThy project

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e031168
Author(s):  
Mats Olof Holmberg ◽  
Helge Malmgren ◽  
Peter Berglund ◽  
Lina Bunketorp-Käll ◽  
Rolf A Heckemann ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Near Infrared ◽  
Well Being ◽  
Secondary Outcome ◽  
Controlled Study ◽  
Ethical Review ◽  
Graves Disease ◽  
Functional Near Infrared Spectroscopy

IntroductionCognitive impairment and reduced well-being are common manifestations of Graves’ disease (GD). These symptoms are not only prevalent during the active phase of the disease but also often prevail for a long time after hyperthyroidism is considered cured. The pathogenic mechanisms involved in these brain-derived symptoms are currently unknown. The overall aim of the CogThy study is to identify the mechanism behind cognitive impairment to be able to recognise GD patients at risk.Methods and analysisThe study is a longitudinal, single-centre, case-controlled study conducted in Göteborg, Sweden on premenopausal women with newly diagnosed GD. The subjects are examined: at referral, at inclusion and then every 3.25 months until 15 months. Examinations include: laboratory measurements; eye evaluation; neuropsychiatric and neuropsychological testing; structural MRI of the whole brain, orbits and medial temporal lobe structures; functional near-infrared spectroscopy of the cerebral prefrontal cortex and self-assessed quality of life questionnaires. The primary outcome measure is the change in medial temporal lobe structure volume. Secondary outcome measures include neuropsychological, neuropsychiatric, hormonal and autoantibody variables. The study opened for inclusion in September 2012 and close for inclusion in October 2019. It will provide novel information on the effect of GD on medial temporal lobe structures and cerebral cortex functionality as well as whether these changes are associated with cognitive and affective impairment, hormonal levels and/or autoantibody levels. It should lead to a broader understanding of the underlying pathogenesis and future treatment perspectives.Ethics and disseminationThe study has been reviewed and approved by the Regional Ethical Review Board in Göteborg, Sweden. The results will be actively disseminated through peer-reviewed journals, national and international conference presentations and among patient organisations after an appropriate embargo time.Trial registration number44321 at the public project database for research and development in Västra Götaland County, Sweden (https://www.researchweb.org/is/vgr/project/44321).

scholarly journals Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment

2010 ◽  
Vol 31 (7) ◽  
pp. 1099-1106 ◽  
Author(s):  
Sarah B. Martin ◽  
Charles D. Smith ◽  
Heather R. Collins ◽  
Fred A. Schmitt ◽  
Brian T. Gold
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe
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