scholarly journals Characterizing memory loss in patients with autoimmune limbic encephalitis hippocampal lesions

Hippocampus ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1114-1120 ◽  
Author(s):  
Meher Lad ◽  
Sinéad L. Mullally ◽  
Alexandra L. Houston ◽  
Tom Kelly ◽  
Timothy D. Griffiths
Keyword(s):  
Limbic Encephalitis ◽  
Memory Loss ◽  
Hippocampal Lesions ◽  
Autoimmune Limbic Encephalitis

scholarly journals Characterising memory loss in patients with autoimmune limbic encephalitis hippocampal lesions

2019 ◽  
Author(s):  
Meher Lad ◽  
Sinéad L. Mullally ◽  
Alexandra L. Houston ◽  
Tom Kelly ◽  
Timothy D. Griffiths
Keyword(s):  
Functional Role ◽  
Limbic Encephalitis ◽  
Memory Loss ◽  
Human Memory ◽  
Homogeneous Population ◽  
Neuropsychological Measures ◽  
Hippocampal Lesions ◽  
Autoimmune Limbic Encephalitis ◽  
Episodic Memories ◽  
Memory And Recall

AbstractSince the publication of Scoville and Milner’s (1957) seminal paper, the precise functional role played by the hippocampus in support of human memory has been fiercely debated. For instance, the single question of whether the hippocampus plays a time-limited or an indelible role in the recollection of personal memories led to a deep and tenacious schism within the field. Similar polarisations arose between those who debated the precise nature of the role played by the hippocampus in support of semantic relative to episodic memories and in recall/recollection relative to familiarity-based recognition. At the epicentre of these divisions lies conflicting neuropsychological findings. These differences likely arise due to the consistent use of heterogeneous patient populations to adjudicate between these positions. Here we utilised traditional neuropsychological measures in a homogenous patient population with a highly discrete hippocampal lesion (i.e. patients with voltage-gated potassium channel complex antibody associated limbic encephalitis (VGKC-LE)). We observed impairment of recent but not remote episodic memory, a preservation of semantic memory, and recall but not recognition memory deficits. We conclude that this increasingly well-characterised group of patients may represent an important homogeneous population in which the functional role played by the hippocampus may be more precisely delineated.

Autoimmune limbic encephalitis and Morvan’s syndrome

2010 ◽  
pp. 5175-5176
Author(s):  
Camilla Buckle ◽  
Angela Vincent
Keyword(s):  
Cell Surface ◽  
Short Term Memory ◽  
Limbic Encephalitis ◽  
Memory Loss ◽  
Surface Proteins ◽  
Cell Surface Proteins ◽  
Term Memory ◽  
Voltage Gated ◽  
Morvan’S Syndrome ◽  
Autoimmune Limbic Encephalitis

Autoimmune limbic encephalitis—typical presentation is with acute or subacute onset of short term memory loss, seizures and disorientation. MRI characteristically shows striking abnormalities in the hippocampus. Antibodies against cell-surface proteins that are components of voltage-gated potassium channel (VGKC) complexes are found in a high proportion and are probably pathogenic. Aside from supportive care, treatment is with immunosuppression, often comprising corticosteroids with intravenous immunoglobulin and/or plasma exchange....

scholarly journals Atypical Association of Autoimmune Limbic Encephalitis with Anti-NMDA Receptor Antibodies in a Young Male Patient: Clinical, Imaging, and Neuropsychological Characteristics

2021 ◽  
pp. 541-548
Author(s):  
José Alberto Choreño-Parra ◽  
Tania de la Rosa-Arredondo ◽  
André Garibay-Gracián ◽  
Ingrid Montes de Oca-Vargas ◽  
Deyanira Capi-Casillas ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Limbic Encephalitis ◽  
Psychiatric Symptoms ◽  
Brain Mri ◽  
Clinical Manifestations ◽  
Memory Loss ◽  
Autoimmune Encephalitis ◽  
Young Male ◽  
Autoimmune Limbic Encephalitis ◽  
Receptor Antibodies

The spectrum of autoimmune encephalitis (AE) encompasses several entities characterized by a variable frequency of psychiatric symptoms, cognitive dysfunction, focal deficits, and seizures. Although patients with AE can be categorized in specific syndromes, overlapping manifestations are also common. Furthermore, atypical correlations between clinical phenotypes and autoantibody profiles could occur in rare cases. Here, we report the rare case of a young adult man attending due to new-onset seizures and a history of memory loss, autonomic disturbances, headache, behavioral changes, and visual and olfactory hallucinations. The patient was subjected to a complete diagnostic approach that included a comprehensive laboratory workup, neuropsychological testing, electroencephalogram, cerebrospinal fluid (CSF) analysis, brain MRI, and positron emission tomography/computed tomography scan that revealed a functional and structural compromise of the bilateral medial temporal lobes. Together with the clinical manifestations of the patient, these findings were compatible with the diagnosis of autoimmune limbic encephalitis (ALE). Strikingly, further analysis of the CSF showed autoantibodies against the N-methyl-D-aspartate (NMDA) receptor. We found very few cases of the co-occurrence of anti-NMDA receptor antibodies and nonparaneoplastic ALE in the literature, especially in male patients. Our report exemplifies the complicated differential diagnosis of ALE and adds clinical information of the association with anti-NMDA receptor antibodies.

ASL MRI and 18F-FDG-PET in autoimmune limbic encephalitis: clues from two paradigmatic cases

2021 ◽  
Author(s):  
Alessandro Dinoto ◽  
Marta Cheli ◽  
Miloš Ajčević ◽  
Franca Dore ◽  
Carmelo Crisafulli ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis ◽  
18F Fdg

Botryoid nuclei of neutrophils and monocytes in autoimmune limbic encephalitis

2012 ◽  
Vol 95 (4) ◽  
pp. 329-330 ◽  
Author(s):  
Akihito Fujimi ◽  
Yuki Ikeda ◽  
Kaoru Ono ◽  
Yuji Kanisawa
Keyword(s):  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis

scholarly journals Determinants of cognition in autoimmune limbic encephalitis—A retrospective cohort study

Hippocampus ◽  
2021 ◽  
Author(s):  
Christoph Mueller ◽  
Lisa M. Langenbruch ◽  
Johanna M. H. Rau ◽  
Tobias Brix ◽  
Christine Strippel ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis

Autoimmune Limbic Encephalitis

2019 ◽  
pp. 567-597
Author(s):  
Shahar Shelly ◽  
Ram Narayan ◽  
Divyanshu Dubey
Keyword(s):  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis

Autoantibodies against Glutamate Receptor ε2-Subunit Detected in a Subgroup of Patients with Reversible Autoimmune Limbic Encephalitis

2007 ◽  
Vol 58 (3) ◽  
pp. 152-158 ◽  
Author(s):  
A. Kimura ◽  
T. Sakurai ◽  
Y. Suzuki ◽  
Y. Hayashi ◽  
I. Hozumi ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Limbic Encephalitis ◽  
Autoimmune Limbic Encephalitis
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