scholarly journals Hippocampal place cell encoding of sloping terrain

Hippocampus ◽  
2018 ◽  
Vol 28 (11) ◽  
pp. 767-782 ◽  
Author(s):  
Blake S. Porter ◽  
Robert Schmidt ◽  
David K. Bilkey
Keyword(s):  
Place Cell ◽  
Sloping Terrain ◽  
Hippocampal Place Cell

scholarly journals Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion

2017 ◽  
Vol 20 (11) ◽  
pp. 1612-1623 ◽  
Author(s):  
Jeffrey D Zaremba ◽  
Anastasia Diamantopoulou ◽  
Nathan B Danielson ◽  
Andres D Grosmark ◽  
Patrick W Kaifosh ◽  
...  
Keyword(s):  
Mouse Model ◽  
Place Cell ◽  
22Q11.2 Deletion ◽  
Cell Dynamics ◽  
Hippocampal Place Cell

scholarly journals Contribution of hippocampal place cell activity to learning and formation of goal-directed navigation in rats

Neuroscience ◽  
2003 ◽  
Vol 117 (4) ◽  
pp. 1025-1035 ◽  
Author(s):  
T Kobayashi ◽  
A.H Tran ◽  
H Nishijo ◽  
T Ono ◽  
G Matsumoto
Keyword(s):  
Cell Activity ◽  
Place Cell ◽  
Hippocampal Place Cell

scholarly journals Manipulating Hippocampal Place Cell Activity by Single-Cell Stimulation in Freely Moving Mice

Cell Reports ◽  
2018 ◽  
Vol 23 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Maria Diamantaki ◽  
Stefano Coletta ◽  
Khaled Nasr ◽  
Roxana Zeraati ◽  
Sophie Laturnus ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Activity ◽  
Place Cell ◽  
Cell Stimulation ◽  
Freely Moving ◽  
Hippocampal Place Cell

An attractor model for hippocampal place cell hysteresis

2001 ◽  
Vol 38-40 ◽  
pp. 1185-1191 ◽  
Author(s):  
Simona Doboli ◽  
Ali A. Minai ◽  
Phillip J. Best ◽  
Aaron M. White
Keyword(s):  
Place Cell ◽  
Attractor Model ◽  
Hippocampal Place Cell

Hippocampal place cell activity during chasing of a moving object associated with reward in rats

Neuroscience ◽  
2008 ◽  
Vol 157 (1) ◽  
pp. 254-270 ◽  
Author(s):  
S.A. Ho ◽  
E. Hori ◽  
T. Kobayashi ◽  
K. Umeno ◽  
A.H. Tran ◽  
...  
Keyword(s):  
Cell Activity ◽  
Place Cell ◽  
Moving Object ◽  
Hippocampal Place Cell

scholarly journals Altered hippocampal place cell representation and theta rhythmicity following moderate prenatal alcohol exposure

2020 ◽  
Author(s):  
Ryan E. Harvey ◽  
Laura E. Berkowitz ◽  
Daniel D. Savage ◽  
Derek A. Hamilton ◽  
Benjamin J. Clark
Keyword(s):  
Spatial Memory ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Place Cell ◽  
Place Cells ◽  
Spatial Tuning ◽  
Cell Firing ◽  
Prenatal Alcohol ◽  
Ca3 Neurons ◽  
Hippocampal Place Cell

SummaryPrenatal alcohol exposure (PAE) leads to profound deficits in spatial memory and synaptic and cellular alterations to the hippocampus that last into adulthood. Neurons in the hippocampus, called place cells, discharge as an animal enters specific places in an environment, establish distinct ensemble codes for familiar and novel places, and are modulated by local theta rhythms. Spatial memory is thought to critically depend on the integrity of hippocampal place cell firing. We therefore tested the hypothesis that hippocampal place cell firing is impaired after PAE by performing in-vivo recordings from the hippocampi (CA1 and CA3) of moderate PAE and control adult rats. Our results show that hippocampal CA3 neurons from PAE rats have reduced spatial tuning. Secondly, CA1 and CA3 neurons from PAE rats are less likely to orthogonalize their firing between directions of travel on a linear track and between contexts in an open arena compared to control neurons. Lastly, reductions in the number of hippocampal place cells exhibiting significant theta rhythmicity and phase precession were observed which may suggest changes to hippocampal microcircuit function. Together, the reduced spatial tuning and sensitivity to context provides a neural systems-level mechanism to explain spatial memory impairment after moderate PAE.

Sign in / Sign up

Export Citation Format

Share Document