scholarly journals Manipulating Hippocampal Place Cell Activity by Single-Cell Stimulation in Freely Moving Mice

Cell Reports ◽  
2018 ◽  
Vol 23 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Maria Diamantaki ◽  
Stefano Coletta ◽  
Khaled Nasr ◽  
Roxana Zeraati ◽  
Sophie Laturnus ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Activity ◽  
Place Cell ◽  
Cell Stimulation ◽  
Freely Moving ◽  
Hippocampal Place Cell

scholarly journals Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Daniel Christopher Haggerty ◽  
Daoyun Ji
Keyword(s):  
Cortical Neurons ◽  
Specific Activity ◽  
Cell Activity ◽  
Place Cell ◽  
Place Cells ◽  
Spatial Behavior ◽  
Freely Moving Rats ◽  
Freely Moving ◽  
Visual Cortical ◽  
Hippocampal Place Cell

Visual cues exert a powerful control over hippocampal place cell activities that encode external spaces. The functional interaction of visual cortical neurons and hippocampal place cells during spatial navigation behavior has yet to be elucidated. Here we show that, like hippocampal place cells, many neurons in the primary visual cortex (V1) of freely moving rats selectively fire at specific locations as animals run repeatedly on a track. The V1 location-specific activity leads hippocampal place cell activity both spatially and temporally. The precise activities of individual V1 neurons fluctuate every time the animal travels through the track, in a correlated fashion with those of hippocampal place cells firing at overlapping locations. The results suggest the existence of visual cortical neurons that are functionally coupled with hippocampal place cells for spatial processing during natural behavior. These visual neurons may also participate in the formation and storage of hippocampal-dependent memories.

scholarly journals Contribution of hippocampal place cell activity to learning and formation of goal-directed navigation in rats

Neuroscience ◽  
2003 ◽  
Vol 117 (4) ◽  
pp. 1025-1035 ◽  
Author(s):  
T Kobayashi ◽  
A.H Tran ◽  
H Nishijo ◽  
T Ono ◽  
G Matsumoto
Keyword(s):  
Cell Activity ◽  
Place Cell ◽  
Hippocampal Place Cell

scholarly journals Priming Spatial Activity by Single-Cell Stimulation in the Dentate Gyrus of Freely Moving Rats

2016 ◽  
Vol 26 (4) ◽  
pp. 536-541 ◽  
Author(s):  
Maria Diamantaki ◽  
Markus Frey ◽  
Patricia Preston-Ferrer ◽  
Andrea Burgalossi
Keyword(s):  
Dentate Gyrus ◽  
Single Cell ◽  
Cell Stimulation ◽  
Spatial Activity ◽  
Freely Moving Rats ◽  
Freely Moving

Hippocampal place cell activity during chasing of a moving object associated with reward in rats

Neuroscience ◽  
2008 ◽  
Vol 157 (1) ◽  
pp. 254-270 ◽  
Author(s):  
S.A. Ho ◽  
E. Hori ◽  
T. Kobayashi ◽  
K. Umeno ◽  
A.H. Tran ◽  
...  
Keyword(s):  
Cell Activity ◽  
Place Cell ◽  
Moving Object ◽  
Hippocampal Place Cell

scholarly journals Conjoint Control of Hippocampal Place Cell Firing by Two Visual Stimuli

2000 ◽  
Vol 116 (2) ◽  
pp. 191-210 ◽  
Author(s):  
André A. Fenton ◽  
Gyorgy Csizmadia ◽  
Robert U. Muller
Keyword(s):  
Visual Stimuli ◽  
Cell Activity ◽  
Place Cell ◽  
Sensory Stimuli ◽  
Local Arrangement ◽  
Cell Firing ◽  
Selected Subset ◽  
Environmental Representation ◽  
Hippocampal Place Cell ◽  
Made In

To better understand how hippocampal place cell activity is controlled by sensory stimuli, and to further elucidate the nature of the environmental representation provided by place cells, we have made recordings in the presence of two distinct visual stimuli under standard conditions and after several manipulations of these stimuli. In line with a great deal of earlier work, we find that place cell activity is constant when repeated recordings are made in the standard conditions in which the centers of the two stimuli, a black card and a white card, are separated by 135° on the wall of a cylindrical recording chamber. Rotating the two stimuli by 45° causes equal rotations of place cell firing fields. Removing either card and rotating the other card also causes fields to rotate equally, showing that the two stimuli are individually salient. Increasing or decreasing the card separation (card reconfiguration) causes a topological distortion of the representation of the cylinder floor such that field centers move relative to each other. We also found that either kind of reconfiguration induces a position-independent decrease in the intensity of place cell firing. We argue that these results are not compatible with either of two previously stated views of the place cell representation; namely, a nonspatial theory in which each place cell is tuned to an arbitrarily selected subset of available stimuli or a rigid map theory. We propose that our results imply that the representation is map-like but not rigid; it is capable of undergoing stretches without altering the local arrangement of firing fields.

scholarly journals Inactivation of the Lateral Entorhinal Area Increases the Influence of Visual Cues on Hippocampal Place Cell Activity

2017 ◽  
Vol 11 ◽  
Author(s):  
Kristin M. Scaplen ◽  
Rohan N. Ramesh ◽  
Negin Nadvar ◽  
Omar J. Ahmed ◽  
Rebecca D. Burwell
Keyword(s):  
Visual Cues ◽  
Cell Activity ◽  
Place Cell ◽  
Entorhinal Area ◽  
Hippocampal Place Cell

scholarly journals Precise spike timing dynamics of hippocampal place cell activity sensitive to cholinergic disruption

Hippocampus ◽  
2017 ◽  
Vol 27 (10) ◽  
pp. 1069-1082 ◽  
Author(s):  
Ehren L. Newman ◽  
Sarah Jo C. Venditto ◽  
Jason R. Climer ◽  
Elijah A. Petter ◽  
Shea N. Gillet ◽  
...  
Keyword(s):  
Cell Activity ◽  
Place Cell ◽  
Spike Timing ◽  
Hippocampal Place Cell

scholarly journals Dominance of the Proximal Coordinate Frame in Determining the Locations of Hippocampal Place Cell Activity During Navigation

2008 ◽  
Vol 99 (1) ◽  
pp. 60-76 ◽  
Author(s):  
Jennifer J. Siegel ◽  
Joshua P. Neunuebel ◽  
James J. Knierim
Keyword(s):  
Spatial Representation ◽  
Reference Frames ◽  
Specific Activity ◽  
Late Phase ◽  
Cell Activity ◽  
Coordinate Frame ◽  
Spatial Frames Of Reference ◽  
Preference Task ◽  
Freely Moving ◽  
Hippocampal Place Cell

The place-specific activity of hippocampal cells provides downstream structures with information regarding an animal's position within an environment and, perhaps, the location of goals within that environment. In rodents, recent research has suggested that distal cues primarily set the orientation of the spatial representation, whereas the boundaries of the behavioral apparatus determine the locations of place activity. The current study was designed to address possible biases in some previous research that may have minimized the likelihood of observing place activity bound to distal cues. Hippocampal single-unit activity was recorded from six freely moving rats as they were trained to perform a tone-initiated place-preference task on an open-field platform. To investigate whether place activity was bound to the room- or platform-based coordinate frame (or both), the platform was translated within the room at an “early” and at a “late” phase of task acquisition (Shift 1 and Shift 2). At both time points, CA1 and CA3 place cells demonstrated room-associated and/or platform-associated activity, or remapped in response to the platform shift. Shift 1 revealed place activity that reflected an interaction between a dominant platform-based (proximal) coordinate frame and a weaker room-based (distal) frame because many CA1 and CA3 place fields shifted to a location intermediate to the two reference frames. Shift 2 resulted in place activity that became more strongly bound to either the platform- or room-based coordinate frame, suggesting the emergence of two independent spatial frames of reference (with many more cells participating in platform-based than in room-based representations).

Hippocampal Place Cell Activity During Overtly Purposeful Behavior

2002 ◽  
pp. 59-80
Author(s):  
André A. Fenton ◽  
Jan Bures ◽  
José Manuel Cimadevilla ◽  
Andrey V. Olypher ◽  
Malgorzata Wesierska ◽  
...  
Keyword(s):  
Cell Activity ◽  
Place Cell ◽  
Purposeful Behavior ◽  
Hippocampal Place Cell
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