Maintenance of long-term potentiation in hippocampal mossy fiber-CA3 pathway requires fine-tuned MMP-9 proteolytic activity

Hippocampus ◽  
2013 ◽  
Vol 23 (6) ◽  
pp. 529-543 ◽  
Author(s):  
Grzegorz Wiera ◽  
Grazyna Wozniak ◽  
Malgorzata Bajor ◽  
Leszek Kaczmarek ◽  
Jerzy W. Mozrzymas
Keyword(s):  
Proteolytic Activity ◽  
Mossy Fiber ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals Metabotropic Glutamate Receptor Antagonist AIDA Blocks Induction of Mossy Fiber-CA3 LTP In Vivo

2005 ◽  
Vol 93 (5) ◽  
pp. 2668-2673 ◽  
Author(s):  
Kenira J. Thompson ◽  
Mario L. Mata ◽  
James E. Orfila ◽  
Edwin J. Barea-Rodriguez ◽  
Joe L. Martinez
Keyword(s):  
Mossy Fiber ◽  
Long Term Potentiation ◽  
Initial Slope ◽  
Maximal Response ◽  
Excitatory Postsynaptic Potential ◽  
Sprague Dawley ◽  
Metabotropic Glutamate ◽  
Term Potentiation

Metabotropic glutamate receptors (mGluR) are implicated in long-term memory storage. mGluR-I and mGluR-II antagonists impede various forms of learning and long-term potentiation (LTP) in animals. Despite the evidence linking mGluR to learning mechanisms, their role in mossy fiber-CA3 long-term potentiation (LTP) is not yet clear. To explain the involvement of mGluR-I in memory mechanisms, we examined the function of the mGluR-I antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA) on the induction of mossy fiber-CA3 LTP in vivo in male Sprague Dawley and Fischer 344 (F344) rats. Acute extracellular mossy fiber (MF) responses were evoked by stimulation of the MF bundle and recorded in the stratum lucidum of CA3. The excitatory postsynaptic potential (EPSP) magnitude was measured by using the initial slope of the field EPSP slope measured 2–3 ms after response onset. After collection of baseline MF-CA3 responses at 0.05 Hz, animals received either ((±))-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid ( N-methyl-d-aspartate-R antagonist, 10 mg/kg ip), naloxone (opioid-R antagonist, 10 mg/kg ip), or AIDA (mGluR antagonist, 1 mg/kg ip or 37.5 nmol ic). LTP was induced by two 100-Hz trains at the intensity sufficient to evoke 50% of the maximal response. Responses were collected for an additional 1 h. AIDA blocked induction of LTP in the mossy fiber pathway ( P < 0.05) in both strains of rats after systemic and in Sprague Dawley rats after intrahippocampal injection.

Long-term potentiation trains induce mossy fiber sprouting

1997 ◽  
Vol 775 (1-2) ◽  
pp. 193-197 ◽  
Author(s):  
Beth Adams ◽  
Melvin Lee ◽  
Margaret Fahnestock ◽  
Ronald J Racine
Keyword(s):  
Mossy Fiber ◽  
Long Term Potentiation ◽  
Mossy Fiber Sprouting ◽  
Term Potentiation
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