Inactivation of ventral midline thalamus produces selective spatial delayed conditional discrimination impairment in the rat

Hippocampus ◽  
2011 ◽  
Vol 22 (4) ◽  
pp. 853-860 ◽  
Author(s):  
Jacqueline R. Hembrook ◽  
Kristen D. Onos ◽  
Robert G. Mair
Keyword(s):  
Conditional Discrimination ◽  
Ventral Midline ◽  
Midline Thalamus ◽  
Delayed Conditional Discrimination

scholarly journals Ventral midline thalamus is not necessary for systemic consolidation of a social memory in the rat

2020 ◽  
Vol 4 ◽  
pp. 239821282093973
Author(s):  
Etienne Quet ◽  
Jean-Christophe Cassel ◽  
Brigitte Cosquer ◽  
Marine Galloux ◽  
Anne Pereira De Vasconcelos ◽  
...  
Keyword(s):  
Food Preference ◽  
Social Memory ◽  
Social Transmission ◽  
Standard Theory ◽  
Remote Memory ◽  
Sham Operation ◽  
Ventral Midline ◽  
Contextual Fear ◽  
Midline Thalamus ◽  
The Difference

According to the standard theory of memory consolidation, recent memories are stored in the hippocampus before their transfer to cortical modules, a process called systemic consolidation. The ventral midline thalamus (reuniens and rhomboid nuclei, ReRh) takes part in this transfer as its lesion disrupts systemic consolidation of spatial and contextual fear memories. Here, we wondered whether ReRh lesions would also affect the systemic consolidation of another type of memory, namely an olfaction-based social memory. To address this question we focused on social transmission of food preference. Adult Long-Evans rats were subjected to N-methyl-d-aspartate-induced, fibre-sparing lesions of the ReRh nuclei or to a sham-operation, and subsequently trained in a social transmission of food preference paradigm. Retrieval was tested on the next day (recent memory, nSham = 10, nReRh = 12) or after a 25-day delay (remote memory, nSham = 10, nReRh = 10). All rats, whether sham-operated or subjected to ReRh lesions, learned and remembered the task normally, whatever the delay. Compared to our former results on spatial and contextual fear memories (Ali et al., 2017; Klein et al., 2019; Loureiro et al., 2012; Quet et al., 2020), the present findings indicate that the ReRh nuclei might not be part of a generic, systemic consolidation mechanism processing all kinds of memories in order to make them persistent. The difference between social transmission of food preference and spatial or contextual fear memories could be explained by the fact that social transmission of food preference is not hippocampus-dependent and that the persistence of social transmission of food preference memory relies on different circuits.

Cholinergic drug effects on a delayed conditional discrimination task in the rat.

1995 ◽  
Vol 109 (3) ◽  
pp. 426-435 ◽  
Author(s):  
Arnoud H. J. Herremans ◽  
Theo H. Hijzen ◽  
Berend Olivier ◽  
Jef L. Slangen
Keyword(s):  
Conditional Discrimination ◽  
Discrimination Task ◽  
Drug Effects ◽  
Delayed Conditional Discrimination ◽  
Cholinergic Drug

Effects of Associatively Significant Posttrial Stimuli on Learning and Memory

1985 ◽  
Vol 37 (2b) ◽  
pp. 101-119
Author(s):  
Ruth M. Colwill
Keyword(s):  
Conditional Discrimination ◽  
Neutral Stimulus ◽  
Food Sample ◽  
The Other ◽  
Short Term ◽  
Significant Stimulus ◽  
Term Retention ◽  
Sample Test ◽  
Delayed Conditional Discrimination ◽  
The Impact

Pigeons were trained on a delayed conditional discrimination in which the choice between two simultaneously presented stimuli depended on how the trial started. Choice of one of the stimuli was reinforced if the trial had been initiated by presentation of a food sample and choice of the other was reinforced if no sample had been presented. Subsequently, test trials were administered on which an associatively significant stimulus was presented during the retention interval. This manipulation was intended to modulate the short-term retention of information about the food sample. It was found that performance on food sample test trials was enhanced by presentation of an excitor for food, disrupted by presentation of an inhibitor for food and unaffected by presentation of an associatively neutral stimulus. The impact of these posttrial stimuli was also assessed on the ability of the food sample to serve as a reinforcer. This was done by recording the development of responding to a keylight that signalled the food sample on these test trials. Compared to the associatively neutral stimulus, both the excitor and the inhibitor interfered with the development of keypecking. These results are discussed with regard to the issue of how posttrial events modulate associative learning.

Environmental enrichment enhances systems-level consolidation of a spatial memory after lesions of the ventral midline thalamus

2017 ◽  
Vol 141 ◽  
pp. 108-123 ◽  
Author(s):  
Mohamad Ali ◽  
Thibault Cholvin ◽  
Marc Antoine Muller ◽  
Brigitte Cosquer ◽  
Christian Kelche ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Environmental Enrichment ◽  
Ventral Midline ◽  
Midline Thalamus

Chlordiazepoxide reduces discriminability but not rate of forgetting in delayed conditional discrimination

1990 ◽  
Vol 101 (4) ◽  
pp. 550-554 ◽  
Author(s):  
S. Tan ◽  
R. C. Kirk ◽  
W. C. Abraham ◽  
N. McNaughton
Keyword(s):  
Conditional Discrimination ◽  
Delayed Conditional Discrimination
Sign in / Sign up

Export Citation Format

Share Document