Excitatory actions of the ventral midline thalamus (rhomboid/reuniens) on the medial prefrontal cortex in the rat

Synapse ◽  
2006 ◽  
Vol 60 (1) ◽  
pp. 45-55 ◽  
Author(s):  
Gonzalo Viana Di Prisco ◽  
Robert P. Vertes
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ventral Midline ◽  
Midline Thalamus

scholarly journals Nucleus reuniens of the midline thalamus: Link between the medial prefrontal cortex and the hippocampus

2007 ◽  
Vol 71 (6) ◽  
pp. 601-609 ◽  
Author(s):  
Robert P. Vertes ◽  
Walter B. Hoover ◽  
Klara Szigeti-Buck ◽  
Csaba Leranth
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Nucleus Reuniens ◽  
Midline Thalamus

Dual medial prefrontal cortex and hippocampus projecting neurons in the paraventricular nucleus of the thalamus

2021 ◽  
Author(s):  
Tatiana D. Viena ◽  
Gabriela E. Rasch ◽  
Timothy A. Allen
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Paraventricular Nucleus ◽  
Calcium Binding ◽  
Integration Site ◽  
Critical Role ◽  
Emotional Memory ◽  
Nucleus Reuniens ◽  
Reward Seeking ◽  
Midline Thalamus

AbstractThe paraventricular nucleus (PVT) of the midline thalamus is a critical higher-order cortico-thalamo-cortical integration site that plays a critical role in various behaviors including reward seeking, cue saliency, and emotional memory. Anatomical studies have shown that PVT projects to both medial prefrontal cortex (mPFC) and hippocampus (HC). However, dual mPFC-HC projecting neurons which could serve a role in synchronizing mPFC and HC activity during PVT-dependent behaviors, have not been explored. Here we used a dual retrograde adenoassociated virus (AAV) tracing approach to characterize the location and proportion of different projection populations that send collaterals to mPFC and/or ventral hippocampus (vHC). Additionally, we examined the distribution of calcium binding proteins calretinin (CR) and calbindin (CB) with respect to these projection populations PVT. We found that PVT contains separate populations of cells that project to mPFC, vHC, and those that innervate both regions. Interestingly, dual mPFC-HC projecting cells expressed neither CR or CB. Topographically, mPFC- and vHC-projecting CB+ and CR+ cells clustered around dual projecting neurons in PVT. These results are consistent with the features of dual mPFC-vHC projecting cells in the nucleus reuniens (RE) and suggestive of a functional mPFC-PVT-vHC system that may support mPFC-vHC interactions in PVT-dependent behaviors.

scholarly journals Dual projecting cells linking thalamic and cortical communication routes between the medial prefrontal cortex and hippocampus

2021 ◽  
Author(s):  
Maximilian Schlecht ◽  
Maanasa Jayachandran ◽  
Gabriela E Rasch ◽  
Timothy Alexander Allen
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Entorhinal Cortex ◽  
Lateral Septum ◽  
Anterior Cingulate ◽  
Cell Populations ◽  
Midline Thalamus ◽  
Cholera Toxin Subunit B ◽  
Cornu Ammonis ◽  
Subunit B

The interactions between the medial prefrontal cortex (mPFC) and hippocampus (HC) are critical for memory and decision making and have been specifically implicated in several neurological disorders including schizophrenia, epilepsy, frontotemporal dementia, and Alzheimers disease. The ventral midline thalamus (vmThal), and lateral entorhinal cortex and perirhinal cortex (LEC/PER) constitute major communication pathways that facilitate mPFC-HC interactions in memory. Although vmThal and LEC/PER circuits have been delineated separately we sought to determine whether these two regions share cell-specific inputs that could influence both routes simultaneously. To do this we used a dual fluorescent retrograde tracing approach using cholera toxin subunit-B (CTB-488 and CTB-594) with injections targeting vmThal and the LEC/PER in rats. Retrograde cell body labeling was examined in key regions of interest within the mPFC-HC system including: (1) mPFC, specifically anterior cingulate cortex (ACC), dorsal and ventral prelimbic cortex (dPL, vPL), and infralimbic cortex (IL); (2) medial and lateral septum (MS, LS); (3) subiculum (Sub) along the dorsal-ventral and proximal-distal axes; and (4) LEC and medial entorhinal cortex (MEC). Results showed that dual vmThal-LEC/PER-projecting cell populations are found in MS, vSub, and the shallow layers II/III of LEC and MEC. We did not find any dual projecting cells in mPFC or in the cornu ammonis (CA) subfields of the HC. Thus, mPFC and HC activity is sent to vmThal and LEC/PER via non-overlapping projection cell populations. Importantly, the dual projecting cell populations in MS, vSub, and LEC are in a unique position to simultaneously influence both cortical and thalamic mPFC-HC pathways critical to memory.

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