Synaptic protein expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss

Hippocampus ◽  
2008 ◽  
Vol 18 (5) ◽  
pp. 440-444 ◽  
Author(s):  
Matthew Goddard ◽  
Yiwen Zheng ◽  
Cynthia L. Darlington ◽  
Paul F. Smith
Keyword(s):  
Protein Expression ◽  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Synaptic Protein ◽  
Vestibular Loss ◽  
Bilateral Vestibular Loss

Dissociable contributions of the mid-ventrolateral frontal cortex and the medial temporal lobe system to human memory

NeuroImage ◽  
2006 ◽  
Vol 31 (4) ◽  
pp. 1790-1801 ◽  
Author(s):  
Anja Dove ◽  
Matthew Brett ◽  
Rhodri Cusack ◽  
Adrian M. Owen
Keyword(s):  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Human Memory

Intracranial Recordings Demonstrate Both Cortical and Medial Temporal Lobe Engagement in Visual Search in Humans

2021 ◽  
pp. 1-29
Author(s):  
S. J. Katarina Slama ◽  
Richard Jimenez ◽  
Sujayam Saha ◽  
David King-Stephens ◽  
Kenneth D. Laxer ◽  
...  
Keyword(s):  
Visual Search ◽  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Association Cortex ◽  
Subcortical Structures ◽  
Spatiotemporal Resolution ◽  
Activity Increase ◽  
Anatomical Space ◽  
Intracranial Recordings

Abstract Visual search is a fundamental human behavior, providing a gateway to understanding other sensory domains as well as the role of search in higher-order cognition. Search has been proposed to include two component processes: inefficient search (search) and efficient search (pop-out). According to extant research, these two processes map onto two separable neural systems located in the frontal and parietal association cortices. In this study, we use intracranial recordings from 23 participants to delineate the neural correlates of search and pop-out with an unprecedented combination of spatiotemporal resolution and coverage across cortical and subcortical structures. First, we demonstrate a role for the medial temporal lobe in visual search, on par with engagement in frontal and parietal association cortex. Second, we show a gradient of increasing engagement over anatomical space from dorsal to ventral lateral frontal cortex. Third, we confirm previous intracranial work demonstrating nearly complete overlap in neural engagement across cortical regions in search and pop-out. We further demonstrate pop-out selectivity, manifesting as activity increase in pop-out as compared to search, in a distributed set of sites including frontal cortex. This result is at odds with the view that pop-out is implemented in low-level visual cortex or parietal cortex alone. Finally, we affirm a central role for the right lateral frontal cortex in search.

scholarly journals Hemispheric Specialization in Human Dorsal Frontal Cortex and Medial Temporal Lobe for Verbal and Nonverbal Memory Encoding

Neuron ◽  
1998 ◽  
Vol 20 (5) ◽  
pp. 927-936 ◽  
Author(s):  
William M Kelley ◽  
Francis M Miezin ◽  
Kathleen B McDermott ◽  
Randy L Buckner ◽  
Marcus E Raichle ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Hemispheric Specialization ◽  
Memory Encoding ◽  
Nonverbal Memory

scholarly journals Intracranial recordings demonstrate medial temporal lobe engagement in visual search in humans

2020 ◽  
Author(s):  
S. J. Katarina Slama ◽  
Richard Jimenez ◽  
Sujayam Saha ◽  
David King-Stephens ◽  
Kenneth D. Laxer ◽  
...  
Keyword(s):  
Visual Search ◽  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Association Cortex ◽  
Subcortical Structures ◽  
Spatiotemporal Resolution ◽  
Activity Increase ◽  
Anatomical Space ◽  
Intracranial Recordings

AbstractVisual search is a fundamental human behavior, which has been proposed to include two component processes: inefficient search (Search) and efficient search (Pop-out). According to extant research, these two processes map onto two separable neural systems located in the frontal and parietal association cortices. In the present study, we use intracranial recordings from 23 participants to delineate the neural correlates of Search and Pop-out with an unprecedented combination of spatiotemporal resolution and coverage across cortical and subcortical structures. First, we demonstrate a role for the medial temporal lobe in visual search, on par with engagement in frontal and parietal association cortex. Second, we show a gradient of increasing engagement over anatomical space from dorsal to ventral lateral frontal cortex. Third, we confirm previous work demonstrating nearly complete overlap in neural engagement across cortical regions in Search and Pop-out. We further demonstrate Pop-out selectivity manifesting as activity increase in Pop-out as compared to Search in a distributed set of sites including frontal cortex. This result is at odds with the view that Pop-out is implemented in low-level visual cortex or parietal cortex alone. Finally, we affirm a central role for the right lateral frontal cortex in Search.

scholarly journals Differentiating Between Healthy Control Participants and Those with Mild Cognitive Impairment Using Volumetric MRI Data

2019 ◽  
Vol 25 (08) ◽  
pp. 800-810 ◽  
Author(s):  
Renée DeVivo ◽  
Lauren Zajac ◽  
Asim Mian ◽  
Anna Cervantes-Arslanian ◽  
Eric Steinberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Temporal Cortex ◽  
Anterior Cingulate ◽  
Cognitively Normal

AbstractObjective:To determine whether volumetric measures of the hippocampus, entorhinal cortex, and other cortical measures can differentiate between cognitively normal individuals and subjects with mild cognitive impairment (MCI).Method:Magnetic resonance imaging (MRI) data from 46 cognitively normal subjects and 50 subjects with MCI as part of the Boston University Alzheimer’s Disease Center research registry and the Alzheimer’s Disease Neuroimaging Initiative were used in this cross-sectional study. Cortical, subcortical, and hippocampal subfield volumes were generated from each subject’s MRI data using FreeSurfer v6.0. Nominal logistic regression models containing these variables were used to identify subjects as control or MCI.Results:A model containing regions of interest (superior temporal cortex, caudal anterior cingulate, pars opercularis, subiculum, precentral cortex, caudal middle frontal cortex, rostral middle frontal cortex, pars orbitalis, middle temporal cortex, insula, banks of the superior temporal sulcus, parasubiculum, paracentral lobule) fit the data best (R2= .7310, whole model test chi-square = 97.16,p< .0001).Conclusions:MRI data correctly classified most subjects using measures of selected medial temporal lobe structures in combination with those from other cortical areas, yielding an overall classification accuracy of 93.75%. These findings support the notion that, while volumes of medial temporal lobe regions differ between cognitively normal and MCI subjects, differences that can be used to distinguish between these two populations are present elsewhere in the brain.

Children show adult-like hippocampal pattern separation for familiar but not novel events

2020 ◽  
Author(s):  
Susan L. Benear ◽  
Elizabeth A. Horwath ◽  
Emily Cowan ◽  
M. Catalina Camacho ◽  
Chi Ngo ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Developmental Change ◽  
Pattern Separation ◽  
Developmental Changes ◽  
Similarity Analysis ◽  
Separation Processes ◽  
Parahippocampal Cortex ◽  
Pattern Similarity

The medial temporal lobe (MTL) undergoes critical developmental change throughout childhood, which aligns with developmental changes in episodic memory. We used representational similarity analysis to compare neural pattern similarity for children and adults in hippocampus and parahippocampal cortex during naturalistic viewing of clips from the same movie or different movies. Some movies were more familiar to participants than others. Neural pattern similarity was generally lower for clips from the same movie, indicating that related content taxes pattern separation-like processes. However, children showed this effect only for movies with which they were familiar, whereas adults showed the effect consistently. These data suggest that children need more exposures to stimuli in order to show mature pattern separation processes.

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