scholarly journals Long-term potentiation as a substrate for memory: Evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning

Hippocampus ◽  
2002 ◽  
Vol 12 (5) ◽  
pp. 592-599 ◽  
Author(s):  
Ki A. Goosens ◽  
Stephen Maren
Keyword(s):  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Pavlovian Fear Conditioning ◽  
Term Potentiation

scholarly journals Fear conditioning and the basolateral amygdala

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 53 ◽  
Author(s):  
Yajie Sun ◽  
Helen Gooch ◽  
Pankaj Sah
Keyword(s):  
Fear Conditioning ◽  
Basolateral Amygdala ◽  
Neural Circuits ◽  
Long Term Potentiation ◽  
Fear Learning ◽  
Pavlovian Fear Conditioning ◽  
Defensive Responses ◽  
Laboratory Rodents ◽  
Term Potentiation

Fear is a response to impending threat that prepares a subject to make appropriate defensive responses, whether to freeze, fight, or flee to safety. The neural circuits that underpin how subjects learn about cues that signal threat, and make defensive responses, have been studied using Pavlovian fear conditioning in laboratory rodents as well as humans. These studies have established the amygdala as a key player in the circuits that process fear and led to a model where fear learning results from long-term potentiation of inputs that convey information about the conditioned stimulus to the amygdala. In this review, we describe the circuits in the basolateral amygdala that mediate fear learning and its expression as the conditioned response. We argue that while the evidence linking synaptic plasticity in the basolateral amygdala to fear learning is strong, there is still no mechanism that fully explains the changes that underpin fear conditioning.

scholarly journals Synaptic plasticity-dependent competition rule influences memory formation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yire Jeong ◽  
Hye-Yeon Cho ◽  
Mujun Kim ◽  
Jung-Pyo Oh ◽  
Min Soo Kang ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Memory Formation ◽  
Specific Pattern ◽  
Memory Encoding ◽  
Competition Rule ◽  
Term Potentiation ◽  
Input Activity

AbstractMemory is supported by a specific collection of neurons distributed in broad brain areas, an engram. Despite recent advances in identifying an engram, how the engram is created during memory formation remains elusive. To explore the relation between a specific pattern of input activity and memory allocation, here we target a sparse subset of neurons in the auditory cortex and thalamus. The synaptic inputs from these neurons to the lateral amygdala (LA) are not potentiated by fear conditioning. Using an optogenetic priming stimulus, we manipulate these synapses to be potentiated by the learning. In this condition, fear memory is preferentially encoded in the manipulated cell ensembles. This change, however, is abolished with optical long-term depression (LTD) delivered shortly after training. Conversely, delivering optical long-term potentiation (LTP) alone shortly after fear conditioning is sufficient to induce the preferential memory encoding. These results suggest a synaptic plasticity-dependent competition rule underlying memory formation.

scholarly journals Erratum: Fear conditioning induces associative long-term potentiation in the amygdala

Nature ◽  
10.1038/35910 ◽  
1998 ◽  
Vol 391 (6669) ◽  
pp. 818-818 ◽  
Author(s):  
Michael T. Rogan ◽  
Ursula V. Stäubli ◽  
Joseph E. LeDoux
Keyword(s):  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation

2010 ◽  
Vol 17 (10) ◽  
pp. 489-493 ◽  
Author(s):  
S. C. Lazzaro ◽  
M. Hou ◽  
C. Cunha ◽  
J. E. LeDoux ◽  
C. K. Cain
Keyword(s):  
Fear Conditioning ◽  
Adrenergic Receptors ◽  
Long Term Potentiation ◽  
Lateral Amygdala ◽  
Term Potentiation

Amygdala, Long-term Potentiation, and Fear Conditioning

2005 ◽  
Vol 11 (1) ◽  
pp. 75-88 ◽  
Author(s):  
Alexander E. Dityatev ◽  
Vadim Y. Bolshakov
Keyword(s):  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Term Potentiation
Sign in / Sign up

Export Citation Format

Share Document