scholarly journals Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation

2010 ◽  
Vol 17 (10) ◽  
pp. 489-493 ◽  
Author(s):  
S. C. Lazzaro ◽  
M. Hou ◽  
C. Cunha ◽  
J. E. LeDoux ◽  
C. K. Cain
Keyword(s):  
Fear Conditioning ◽  
Adrenergic Receptors ◽  
Long Term Potentiation ◽  
Lateral Amygdala ◽  
Term Potentiation

Fear conditioning occludes late-phase long-term potentiation at thalamic input synapses onto the lateral amygdala in rat brain slices

2012 ◽  
Vol 506 (1) ◽  
pp. 121-125 ◽  
Author(s):  
Ingie Hong ◽  
Jeongyeon Kim ◽  
Beomjong Song ◽  
Kyungjoon Park ◽  
Kisoon Shin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Fear Conditioning ◽  
Late Phase ◽  
Brain Slices ◽  
Long Term Potentiation ◽  
Lateral Amygdala ◽  
Thalamic Input ◽  
Term Potentiation

scholarly journals Synaptic plasticity-dependent competition rule influences memory formation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yire Jeong ◽  
Hye-Yeon Cho ◽  
Mujun Kim ◽  
Jung-Pyo Oh ◽  
Min Soo Kang ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Memory Formation ◽  
Specific Pattern ◽  
Memory Encoding ◽  
Competition Rule ◽  
Term Potentiation ◽  
Input Activity

AbstractMemory is supported by a specific collection of neurons distributed in broad brain areas, an engram. Despite recent advances in identifying an engram, how the engram is created during memory formation remains elusive. To explore the relation between a specific pattern of input activity and memory allocation, here we target a sparse subset of neurons in the auditory cortex and thalamus. The synaptic inputs from these neurons to the lateral amygdala (LA) are not potentiated by fear conditioning. Using an optogenetic priming stimulus, we manipulate these synapses to be potentiated by the learning. In this condition, fear memory is preferentially encoded in the manipulated cell ensembles. This change, however, is abolished with optical long-term depression (LTD) delivered shortly after training. Conversely, delivering optical long-term potentiation (LTP) alone shortly after fear conditioning is sufficient to induce the preferential memory encoding. These results suggest a synaptic plasticity-dependent competition rule underlying memory formation.

scholarly journals Erratum: Fear conditioning induces associative long-term potentiation in the amygdala

Nature ◽  
10.1038/35910 ◽  
1998 ◽  
Vol 391 (6669) ◽  
pp. 818-818 ◽  
Author(s):  
Michael T. Rogan ◽  
Ursula V. Stäubli ◽  
Joseph E. LeDoux
Keyword(s):  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Term Potentiation
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