scholarly journals Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol

2021 ◽  
Author(s):  
George N. Ioannou ◽  
Sum P. Lee ◽  
Peter S. Linsley ◽  
Vivian Gersuk ◽  
Matthew M. Yeh ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Hepatic Carcinogenesis

scholarly journals The Role of Three‐Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery

Hepatology ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 510-521 ◽  
Author(s):  
Alina M. Allen ◽  
Vijay H. Shah ◽  
Terry M. Therneau ◽  
Sudhakar K. Venkatesh ◽  
Taofic Mounajjed ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Magnetic Resonance ◽  
Nonalcoholic Steatohepatitis ◽  
Three Dimensional ◽  
Magnetic Resonance Elastography ◽  
Obese Patients

scholarly journals Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring Autophagy

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiaji Hu ◽  
Hanglu Ying ◽  
Jie Yao ◽  
Longhe Yang ◽  
Wenhui Jin ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Underlying Mechanism ◽  
Protective Role ◽  
Hepatocellular Injury ◽  
Deficient Diet ◽  
Neuroprotective Effects ◽  
Pathway Activation ◽  
Elevated Expression ◽  
Anti Inflammatory

Nonalcoholic steatohepatitis (NASH) has become one of the serious causes of chronic liver diseases, characterized by hepatic steatosis, hepatocellular injury, inflammation and fibrosis, and lack of efficient therapeutic agents. Palmitoylethanolamide (PEA) is an endogenous bioactive lipid with various pharmacological activities, including anti-inflammatory, analgesic, and neuroprotective effects. However, the effect of PEA on nonalcoholic steatohepatitis is still unknown. Our study aims to explore the potential protective role of PEA on NASH and to reveal the underlying mechanism. In this study, the C57BL/6 mice were used to establish the NASH model through methionine- and choline-deficient (MCD) diet feeding. Here, we found that PEA treatment significantly improved liver function, alleviated hepatic pathological changes, and attenuated the lipid accumulation and hepatic fibrosis in NASH mice induced by MCD diet feeding. Mechanistically, the anti-steatosis effect of PEA may be due to the suppressed expression of ACC1 and CD36, elevated expression of PPAR-α, and the phosphorylation levels of AMPK. In addition, hepatic oxidative stress was greatly inhibited in MCD-fed mice treated with PEA via enhancing the expression and activities of antioxidant enzymes, including GSH-px and SOD. Moreover, PEA exerted a clear anti-inflammatory effect though ameliorating the expression of inflammatory mediators and suppressing the NLRP3 inflammasome pathway activation. Furthermore, the impaired autophagy in MCD-induced mice was reactivated with PEA treatment. Taken together, our research suggested that PEA protects against NASH through the inhibition of inflammation and restoration of autophagy. Thus, PEA may represent an efficient therapeutic agent to treat NASH.

scholarly journals The role of extended criteria donors in liver transplantation for nonalcoholic steatohepatitis

Surgery ◽  
2016 ◽  
Vol 160 (6) ◽  
pp. 1533-1543 ◽  
Author(s):  
Francesca M. Dimou ◽  
Hemalkumar B. Mehta ◽  
Deepak Adhikari ◽  
Robert C. Harland ◽  
Taylor S. Riall ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Nonalcoholic Steatohepatitis ◽  
Extended Criteria Donors

Role of high-fructose diet in experimental induction of nonalcoholic steatohepatitis in rats

2017 ◽  
Vol 45 (3) ◽  
pp. 141
Author(s):  
AssmaaM.F. Abdel-Aziz El Sheikh ◽  
SobhyA El-Hamid Hassan ◽  
ManalM El-Batch ◽  
SohaS Zakareia
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
High Fructose Diet ◽  
Experimental Induction ◽  
High Fructose

scholarly journals MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice

2019 ◽  
Vol 20 (23) ◽  
pp. 6084 ◽  
Author(s):  
Mailin Gan ◽  
Linyuan Shen ◽  
Yuan Fan ◽  
Ya Tan ◽  
Ting Zheng ◽  
...  
Keyword(s):  
Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Therapeutic Effects ◽  
Liver Inflammation ◽  
Hepatic Inflammation ◽  
Potential Therapeutic Target ◽  
Genistein Treatment ◽  
Anti Oxidant ◽  
Anti Inflammatory

Effective, targeted therapy for chronic liver disease nonalcoholic steatohepatitis (NASH) is imminent. MicroRNAs (miRNAs) are a potential therapeutic target, and natural products that regulate miRNA expression may be a safe and effective treatment strategy for liver disease. Here, we investigated the functional role of miR-451 and the therapeutic effects of genistein in the NASH mouse model. MiR-451 was downregulated in various types of liver inflammation, and subsequent experiments showed that miR-451 regulates liver inflammation via IL1β. Genistein is a phytoestrogen with anti-inflammatory and anti-oxidant effects. Interestingly, we found that the anti-inflammatory effects of genistein were related to miR-451 and was partially antagonized by the miR-451 inhibitor. MiR-451 overexpression or genistein treatment inhibited IL1β expression and inflammation. Taken together, this study shows that miR-451 has a protective effect on hepatic inflammation, and genistein can be used as a natural promoter of miR-451 to ameliorate NASH.

scholarly journals Role of ethnicity in overweight and obese patients with nonalcoholic steatohepatitis

Hepatology ◽  
2011 ◽  
Vol 54 (3) ◽  
pp. 837-845 ◽  
Author(s):  
Romina Lomonaco ◽  
Carolina Ortiz-Lopez ◽  
Beverly Orsak ◽  
Joan Finch ◽  
Amy Webb ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Obese Patients

T1613 The Role of Psychological Stress On the Progression of Nonalcoholic Steatohepatitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-849
Author(s):  
Yasuhiro Tsuda ◽  
Hideo Fukui ◽  
Shinya Fujiwara ◽  
Katsuhiko Miyaji ◽  
Akira Fukuda ◽  
...  
Keyword(s):  
Psychological Stress ◽  
Nonalcoholic Steatohepatitis

scholarly journals Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model

2012 ◽  
Vol 287 (53) ◽  
pp. 44526-44535 ◽  
Author(s):  
Yusuke Nakatsu ◽  
Yuichiro Otani ◽  
Hideyuki Sakoda ◽  
Jun Zhang ◽  
Ying Guo ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Rodent Model ◽  
Pin1 Protein
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