scholarly journals Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model

2012 ◽  
Vol 287 (53) ◽  
pp. 44526-44535 ◽  
Author(s):  
Yusuke Nakatsu ◽  
Yuichiro Otani ◽  
Hideyuki Sakoda ◽  
Jun Zhang ◽  
Ying Guo ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Rodent Model ◽  
Pin1 Protein

Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia

2011 ◽  
Vol 21 (8) ◽  
pp. 2359-2364 ◽  
Author(s):  
Peter J. Manley ◽  
Amy Zartman ◽  
Daniel V. Paone ◽  
Christopher S. Burgey ◽  
Darrell A. Henze ◽  
...  
Keyword(s):  
Rodent Model ◽  
In Vivo Efficacy

scholarly journals The Role of Three‐Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery

Hepatology ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 510-521 ◽  
Author(s):  
Alina M. Allen ◽  
Vijay H. Shah ◽  
Terry M. Therneau ◽  
Sudhakar K. Venkatesh ◽  
Taofic Mounajjed ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Magnetic Resonance ◽  
Nonalcoholic Steatohepatitis ◽  
Three Dimensional ◽  
Magnetic Resonance Elastography ◽  
Obese Patients

scholarly journals Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring Autophagy

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiaji Hu ◽  
Hanglu Ying ◽  
Jie Yao ◽  
Longhe Yang ◽  
Wenhui Jin ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Underlying Mechanism ◽  
Protective Role ◽  
Hepatocellular Injury ◽  
Deficient Diet ◽  
Neuroprotective Effects ◽  
Pathway Activation ◽  
Elevated Expression ◽  
Anti Inflammatory

Nonalcoholic steatohepatitis (NASH) has become one of the serious causes of chronic liver diseases, characterized by hepatic steatosis, hepatocellular injury, inflammation and fibrosis, and lack of efficient therapeutic agents. Palmitoylethanolamide (PEA) is an endogenous bioactive lipid with various pharmacological activities, including anti-inflammatory, analgesic, and neuroprotective effects. However, the effect of PEA on nonalcoholic steatohepatitis is still unknown. Our study aims to explore the potential protective role of PEA on NASH and to reveal the underlying mechanism. In this study, the C57BL/6 mice were used to establish the NASH model through methionine- and choline-deficient (MCD) diet feeding. Here, we found that PEA treatment significantly improved liver function, alleviated hepatic pathological changes, and attenuated the lipid accumulation and hepatic fibrosis in NASH mice induced by MCD diet feeding. Mechanistically, the anti-steatosis effect of PEA may be due to the suppressed expression of ACC1 and CD36, elevated expression of PPAR-α, and the phosphorylation levels of AMPK. In addition, hepatic oxidative stress was greatly inhibited in MCD-fed mice treated with PEA via enhancing the expression and activities of antioxidant enzymes, including GSH-px and SOD. Moreover, PEA exerted a clear anti-inflammatory effect though ameliorating the expression of inflammatory mediators and suppressing the NLRP3 inflammasome pathway activation. Furthermore, the impaired autophagy in MCD-induced mice was reactivated with PEA treatment. Taken together, our research suggested that PEA protects against NASH through the inhibition of inflammation and restoration of autophagy. Thus, PEA may represent an efficient therapeutic agent to treat NASH.

scholarly journals From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia

2020 ◽  
Vol 134 (8) ◽  
pp. 1001-1025 ◽  
Author(s):  
Sonya Frazier ◽  
Martin W. McBride ◽  
Helen Mulvana ◽  
Delyth Graham
Keyword(s):  
Animal Models ◽  
Cell Types ◽  
Rodent Model ◽  
Hypertensive Disorder ◽  
Model Studies ◽  
Genetic Components ◽  
Immune Mediated ◽  
Hypertensive Disorder Of Pregnancy

Abstract Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR-126, and miR-148/152 respectively, by examining expression of the miRNAs, their inducers, and potential gene targets. This review evaluates the role of miR-210, miR-126, and miR-148/152 in PE by comparing findings from the three rodent model studies with in vitro studies, other animal models, and preeclamptic patients to provide comprehensive insight into genetic components and pathological processes in the placenta contributing to PE. The majority of studies demonstrate miR-210 is upregulated in PE in part driven by HIF-1α and NF-κBp50, stimulated by hypoxia and/or immune-mediated processes. Elevated miR-210 may contribute to PE via inhibiting anti-inflammatory Th2-cytokines. Studies report an up- and downregulation of miR-126, arguably reflecting differences in expression between cell types and its multifunctional capacity. MiR-126 may play a pro-angiogenic role by mediating the PI3K-Akt pathway. Most studies report miR-148/152 family members are upregulated in PE. Evidence suggests they may inhibit DNA methylation of genes involved in metabolic and inflammatory pathways. Given the genetic heterogeneity of PE, it is unlikely that a single placental miRNA is a suitable therapeutic target for all patients. Investigating miRNAs in PE subtypes in patients and animal models may represent a more appropriate approach going forward. Developing methods for targeting placental miRNAs and specific placental cell types remains crucial for research seeking to target placental miRNAs as a novel treatment for PE.

Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis

2012 ◽  
Vol 674 (2-3) ◽  
pp. 143-152 ◽  
Author(s):  
Luigina Graziosi ◽  
Andrea Mencarelli ◽  
Chiara Santorelli ◽  
Barbara Renga ◽  
Sabrina Cipriani ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
P38 Mapk ◽  
Peritoneal Metastasis ◽  
Rodent Model ◽  
Cancer Dissemination

scholarly journals The role of extended criteria donors in liver transplantation for nonalcoholic steatohepatitis

Surgery ◽  
2016 ◽  
Vol 160 (6) ◽  
pp. 1533-1543 ◽  
Author(s):  
Francesca M. Dimou ◽  
Hemalkumar B. Mehta ◽  
Deepak Adhikari ◽  
Robert C. Harland ◽  
Taylor S. Riall ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Nonalcoholic Steatohepatitis ◽  
Extended Criteria Donors

Role of high-fructose diet in experimental induction of nonalcoholic steatohepatitis in rats

2017 ◽  
Vol 45 (3) ◽  
pp. 141
Author(s):  
AssmaaM.F. Abdel-Aziz El Sheikh ◽  
SobhyA El-Hamid Hassan ◽  
ManalM El-Batch ◽  
SohaS Zakareia
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
High Fructose Diet ◽  
Experimental Induction ◽  
High Fructose

scholarly journals MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice

2019 ◽  
Vol 20 (23) ◽  
pp. 6084 ◽  
Author(s):  
Mailin Gan ◽  
Linyuan Shen ◽  
Yuan Fan ◽  
Ya Tan ◽  
Ting Zheng ◽  
...  
Keyword(s):  
Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Therapeutic Effects ◽  
Liver Inflammation ◽  
Hepatic Inflammation ◽  
Potential Therapeutic Target ◽  
Genistein Treatment ◽  
Anti Oxidant ◽  
Anti Inflammatory

Effective, targeted therapy for chronic liver disease nonalcoholic steatohepatitis (NASH) is imminent. MicroRNAs (miRNAs) are a potential therapeutic target, and natural products that regulate miRNA expression may be a safe and effective treatment strategy for liver disease. Here, we investigated the functional role of miR-451 and the therapeutic effects of genistein in the NASH mouse model. MiR-451 was downregulated in various types of liver inflammation, and subsequent experiments showed that miR-451 regulates liver inflammation via IL1β. Genistein is a phytoestrogen with anti-inflammatory and anti-oxidant effects. Interestingly, we found that the anti-inflammatory effects of genistein were related to miR-451 and was partially antagonized by the miR-451 inhibitor. MiR-451 overexpression or genistein treatment inhibited IL1β expression and inflammation. Taken together, this study shows that miR-451 has a protective effect on hepatic inflammation, and genistein can be used as a natural promoter of miR-451 to ameliorate NASH.

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