scholarly journals Early Allograft Dysfunction Increases Hospital Associated Costs After Liver Transplantation—A Propensity Score–Matched Analysis

2020 ◽  
Author(s):  
Simon Moosburner ◽  
Igor M. Sauer ◽  
Frank Förster ◽  
Thomas Winklmann ◽  
Joseph Maria George Vernon Gassner ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Propensity Score ◽  
Allograft Dysfunction ◽  
Early Allograft Dysfunction

scholarly journals Uric Acid as a Predictor for Early Allograft Dysfunction after Living Donor Liver Transplantation: A Prospective Observational Study

2021 ◽  
Vol 10 (12) ◽  
pp. 2729
Author(s):  
Li-Min Hu ◽  
Hsin-I Tsai ◽  
Chao-Wei Lee ◽  
Hui-Ming Chen ◽  
Wei-Chen Lee ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Uric Acid ◽  
Observational Study ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Prospective Observational Study ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Allograft Dysfunction ◽  
Early Allograft Dysfunction

Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.

scholarly journals Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation

2012 ◽  
Vol 18 (2) ◽  
pp. 166-176 ◽  
Author(s):  
Benjamin H. Friedman ◽  
Joshua H. Wolf ◽  
Liqing Wang ◽  
Mary E. Putt ◽  
Abraham Shaked ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Serum Cytokine ◽  
Allograft Dysfunction ◽  
Cytokine Profiles ◽  
Early Allograft Dysfunction

scholarly journals Role of plasmapheresis in early allograft dysfunction following deceased donor liver transplantation

2017 ◽  
Vol 6 (1) ◽  
pp. 24
Author(s):  
Ashwin Rammohan ◽  
Deepti Sachan ◽  
Satish Logidasan ◽  
Jeswanth Sathyanesan ◽  
Ravichandran Palaniappan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Deceased Donor ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Allograft Dysfunction ◽  
Deceased Donor Liver Transplantation ◽  
Early Allograft Dysfunction

scholarly journals Combination of Early Allograft Dysfunction and Protein Expression Patterns Predicts Outcome of Liver Transplantation From Donation After Cardiac Death

2021 ◽  
Vol 8 ◽  
Author(s):  
Qiang Wei ◽  
Junbin Zhou ◽  
Kun Wang ◽  
Xuanyu Zhang ◽  
Junli Chen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Expression Patterns ◽  
Sirtuin 1 ◽  
Donation After Cardiac Death ◽  
Heme Oxygenase 1 ◽  
Survival Prognosis ◽  
Allograft Dysfunction ◽  
Tnf Α ◽  
Factor Α ◽  
Early Allograft Dysfunction

Early allograft dysfunction (EAD) after liver transplantation (LT) accompanies poor prognosis. This study aims to explore the relationship between pretransplant intrahepatic proteins and the incidence of EAD, and the value of combined EAD and protein profiles for predicting recipient and graft survival prognosis. Liver biopsy specimens of 105 pretransplant grafts used for LT were collected and used for immunohistochemistry analysis of 5 proteins. And matched clinical data of donor, recipient, transplantation, and prognosis were analyzed. The incidence of EAD was 41.9% (44/105) in this cohort. Macrovesicular steatosis (P = 0.016), donor body mass index (P = 0.013), recipients' pretransplant serum creatinine (P = 0.036), and intrahepatic expression of heme oxygenase 1 (HO1) (P = 0.015) and tumor necrosis factor α (TNF-α) (P = 0.039) were independent predictors of EAD. Inferior graft and recipient prognosis were observed in patients who experienced EAD (P = 0.028 and 0.031) or received grafts with higher expression of sirtuin 1 (P = 0.005 and 0.013). The graft and recipient survival were worst in patients with both EAD and high expression of sirtuin 1 (P = 0.001 and 0.004). In conclusion, pretransplant intrahepatic expression of HO1 and TNF-α are associated with the incidence of EAD. The combination of EAD and EAD-unrelated proteins showed superiority in distinguishing recipients with worse prognosis.

Serum glycomics early after liver transplantation relate to graft loss 3 months after liver transplantation independently of early allograft dysfunction

2020 ◽  
Vol 73 ◽  
pp. S286-S287
Author(s):  
Verhelst Xavier ◽  
Anja Geerts ◽  
Helena Degroote ◽  
Roos Colman ◽  
Aude Vanlander ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Loss ◽  
Allograft Dysfunction ◽  
Early Allograft Dysfunction
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