A new index predicts early allograft dysfunction following living donor liver transplantation: A propensity score analysis

2017 ◽  
Vol 49 (11) ◽  
pp. 1225-1232 ◽  
Author(s):  
Jiu-Lin Song ◽  
Jian Yang ◽  
Lu-Nan Yan ◽  
Jia-Yin Yang ◽  
Tian-Fu Wen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Propensity Score ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Propensity Score Analysis ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Allograft Dysfunction ◽  
Score Analysis ◽  
Early Allograft Dysfunction

scholarly journals Uric Acid as a Predictor for Early Allograft Dysfunction after Living Donor Liver Transplantation: A Prospective Observational Study

2021 ◽  
Vol 10 (12) ◽  
pp. 2729
Author(s):  
Li-Min Hu ◽  
Hsin-I Tsai ◽  
Chao-Wei Lee ◽  
Hui-Ming Chen ◽  
Wei-Chen Lee ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Uric Acid ◽  
Observational Study ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Prospective Observational Study ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Allograft Dysfunction ◽  
Early Allograft Dysfunction

Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.

scholarly journals A Lipidomics Study Reveals Lipid Signatures Associated with Early Allograft Dysfunction in Living Donor Liver Transplantation

2018 ◽  
Vol 8 (1) ◽  
pp. 30 ◽  
Author(s):  
Hsin-I Tsai ◽  
Chi-Jen Lo ◽  
Chih-Wen Zheng ◽  
Chao-Wei Lee ◽  
Wei-Chen Lee ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Graft Function ◽  
Resonance Spectroscopy ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Allograft Dysfunction ◽  
Latent Structures ◽  
Early Allograft Dysfunction

Liver transplantation has become the ultimate treatment for patients with end stage liver disease. However, early allograft dysfunction (EAD) has been associated with allograft loss or mortality after transplantation. We aim to utilize a metabolomic platform to identify novel biomarkers for more accurate correlation with EAD using blood samples collected from 51 recipients undergoing living donor liver transplantation (LDLT) by 1H-nuclear magnetic resonance spectroscopy (NMR) and liquid chromatography coupled with mass spectrometry (LC-MS). Principal component analysis (PCA) and orthogonal projection to latent structures-discriminant analysis (OPLS-DA) were used to search for a relationship between the metabolomic profiles and the presence of EAD.Cholesteryl esters (CEs), triacylglycerols (TGs), phosphatidylcholines (PCs) and lysophosphatidylcholine (lysoPC) were identified in association with EAD and a combination of cholesterol oleate, PC (16:0/16:0), and lysoPC (16:0) gave an optimal area under the curve (AUC) of 0.9487 and 0.7884 in the prediction of EAD and in-hospital mortality, respectively after LDLT. Such biomarkers may add as a potential clinical panel for the prediction of graft function and mortality after LDLT.

scholarly journals A nomogram for prediction of early allograft dysfunction in living donor liver transplantation

Medicine ◽  
2020 ◽  
Vol 99 (42) ◽  
pp. e22749
Author(s):  
Yu-Chen Ko ◽  
Hsin-I Tsai ◽  
Chao-Wei Lee ◽  
Jr-Rung Lin ◽  
Wei-Chen Lee ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Allograft Dysfunction ◽  
Early Allograft Dysfunction
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