scholarly journals Nonalcoholic Fatty Liver Disease Impairs the Liver–Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis

2020 ◽  
Vol 4 (11) ◽  
pp. 1610-1623 ◽  
Author(s):  
Julie Steen Pedersen ◽  
Marte Opseth Rygg ◽  
Viggo Bjerregaard Kristiansen ◽  
Beth Hærstedt Olsen ◽  
Reza Rafiolsadat Serizawa ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Alpha Cell ◽  
Hepatic Inflammation ◽  
Cell Axis ◽  
Nonalcoholic Fatty Liver

scholarly journals Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease

Hepatology ◽  
2015 ◽  
Vol 63 (4) ◽  
pp. 1155-1169 ◽  
Author(s):  
Hyunjoo Kwon ◽  
Kyoungsub Song ◽  
Chang Han ◽  
Weina Chen ◽  
Ying Wang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hedgehog Signaling ◽  
Hepatic Inflammation ◽  
Nonalcoholic Fatty Liver

scholarly journals Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease

2021 ◽  
Author(s):  
Jin Young Huh ◽  
Alan R. Saltiel
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hepatic Inflammation ◽  
Hepatic Lipid Metabolism ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Lipid ◽  
Iκb Kinase

AbstractNonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is strongly associated with obesity-related ectopic fat accumulation in the liver. Hepatic lipid accumulation encompasses a histological spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma. Given that dysregulated hepatic lipid metabolism may be an onset factor in NAFLD, understanding how hepatic lipid metabolism is modulated in healthy subjects and which steps are dysregulated in NAFLD subjects is crucial to identify effective therapeutic targets. Additionally, hepatic inflammation is involved in chronic hepatocyte damage during NAFLD progression. As a key immune signaling hub that mediates NF-κB activation, the IκB kinase (IKK) complex, including IKKα, IKKβ, and IKKγ (NEMO), has been studied as a crucial regulator of the hepatic inflammatory response and hepatocyte survival. Notably, TANK-binding kinase 1 (TBK1), an IKK-related kinase, has recently been revealed as a potential link between hepatic inflammation and energy metabolism. Here, we review (1) the biochemical steps of hepatic lipid metabolism; (2) dysregulated lipid metabolism in obesity and NAFLD; and (3) the roles of IKKs and TBK1 in obesity and NAFLD.

Sign in / Sign up

Export Citation Format

Share Document