scholarly journals Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease

Hepatology ◽  
2015 ◽  
Vol 63 (4) ◽  
pp. 1155-1169 ◽  
Author(s):  
Hyunjoo Kwon ◽  
Kyoungsub Song ◽  
Chang Han ◽  
Weina Chen ◽  
Ying Wang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hedgehog Signaling ◽  
Hepatic Inflammation ◽  
Nonalcoholic Fatty Liver

scholarly journals Nonalcoholic Fatty Liver Disease Impairs the Liver–Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis

2020 ◽  
Vol 4 (11) ◽  
pp. 1610-1623 ◽  
Author(s):  
Julie Steen Pedersen ◽  
Marte Opseth Rygg ◽  
Viggo Bjerregaard Kristiansen ◽  
Beth Hærstedt Olsen ◽  
Reza Rafiolsadat Serizawa ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Alpha Cell ◽  
Hepatic Inflammation ◽  
Cell Axis ◽  
Nonalcoholic Fatty Liver

scholarly journals Nocturnal Hypoxia Activation of the Hedgehog Signaling Pathway Affects Pediatric Nonalcoholic Fatty Liver Disease Severity

2019 ◽  
Vol 3 (7) ◽  
pp. 883-893
Author(s):  
Shikha S. Sundaram ◽  
Marzena Swiderska‐Syn ◽  
Ronald J. Sokol ◽  
Ann C. Halbower ◽  
Kelley E. Capocelli ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Signaling Pathway ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Nonalcoholic Fatty Liver

scholarly journals Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

2019 ◽  
Vol 20 (9) ◽  
pp. 2369 ◽  
Author(s):  
Chanbin Lee ◽  
Jieun Kim ◽  
Sihyung Wang ◽  
Sumi Sung ◽  
Namgyu Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hedgehog Signaling ◽  
Lipid Uptake ◽  
Nonalcoholic Fatty Liver ◽  
Kombucha Tea ◽  
Underlying Mechanisms

Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on the fatty liver remain unclear. Therefore, we investigated the potential role of KT and its underlying mechanisms on nonalcoholic fatty liver disease (NAFLD). db/db mice that were fed methionine/choline-deficient (MCD) diets for seven weeks were treated for vehicle (M + V) or KT (M + K) and fed with MCD for four additional weeks. Histomorphological injury and increased levels of liver enzymes and lipids were evident in the M + V group, whereas these symptoms were ameliorated in the M + K group. The M + K group had more proliferating and less apoptotic hepatocytic cells than the M + V group. Lipid uptake and lipogenesis significantly decreased, and free fatty acid (FFA) oxidation increased in the M + K, when compared with the M + V group. With the reduction of hedgehog signaling, inflammation and fibrosis also declined in the M + K group. Palmitate (PA) treatment increased the accumulation of lipid droplets and decreased the viability of primary hepatocytes, whereas KT suppressed PA-induced damage in these cells by enhancing intracellular lipid disposal. These results suggest that KT protects hepatocytes from lipid toxicity by influencing the lipid metabolism, and it attenuates inflammation and fibrosis, which contributes to liver restoration in mice with NAFLD.

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