scholarly journals Markedly Elevated Serum Aspartate Aminotransferase to Alanine Aminotransferase Ratio: A Clue to Hepatic Neoplasia

2020 ◽  
Vol 4 (7) ◽  
pp. 1099-1101
Author(s):  
Brian T. Lee ◽  
Kathan Chintamaneni ◽  
Neil Kaplowitz
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Elevated Serum ◽  
Serum Aspartate Aminotransferase ◽  
Hepatic Neoplasia

scholarly journals Elevated serum aspartate aminotransferase levels concomitant with normal alanine aminotransferase levels in older low body weight people: Preliminary findings from a community-based epidemiological study

2019 ◽  
Author(s):  
Michi Shibata ◽  
Kei Nakajima
Keyword(s):  
Body Weight ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Elevated Serum ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Healthy Population ◽  
Gamma Glutamyl Transpeptidase ◽  
Cross Sectional ◽  
Serum Aspartate Aminotransferase

AbstractBackgroundSerum enzyme levels, including hepatic transaminase, are unknown in older people with low body weight (LBW), who can easily experience sarcopenia. Therefore, we addressed preliminarily this issue in a cross-sectional study of an apparently healthy population.MethodsWe investigated the relationship of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and total bilirubin levels with body mass index (BMI) and age in 79,623 subjects aged 20–80 years who underwent an annual checkup.ResultsSerum levels of AST, ALP, and LDH levels were significantly higher in older (≥50 years) non-obese subjects compared with younger (< 50 years) corresponding subjects. Serum AST levels were significantly higher in older LBW subjects (BMI≤18.9 kg/m2) than in those with a reference BMI of 20.9–22.9 kg/m2. Serum AST levels showed a J-shaped curve against BMI, whereas ALT and GGT levels showed a linear relationship, regardless of age.ConclusionElevated serum AST levels concomitant with normal ALT levels, which might reflect systemic damage of skeletal muscle, may be prevalent in older LBW people. Further studies need to determine whether such a condition is equivalent to the etiology of sarcopenia.

scholarly journals Effect of Terminalia Chebula (Haritaki) on Serum Aspartate Aminotransferase, Alanine Aminotransferase in Paracetemol induced liver damage in Wister Albino Rats

2015 ◽  
Vol 10 (1) ◽  
pp. 1-5
Author(s):  
Tania Yeasmin ◽  
Qazi Shamima Akhter ◽  
Syeda Tasfia Siddika ◽  
Fayeza Karim
Keyword(s):  
Body Weight ◽  
Liver Function ◽  
Liver Damage ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Basal Diet ◽  
Base Line ◽  
Terminalia Chebula ◽  
Serum Aspartate Aminotransferase ◽  
Bonferroni Test

Background: Liver plays a major role in detoxification and excretion of many endogenous and exogenous compounds. Any injury may lead to severe liver damage and impairment of liver function. Harbal plants such as Terminalia chebula (Haritaki) may have free radical scavenging activity thereby can be used for the prevention and treatment of liver damage.Objective: To observe the effect of Terminalia chebula on paracetamol induced changes of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in Wister albino rats.Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka from January to December’ 2013. Total 44 rats with age 90 to 120 days, weighing between 150 to 200 gm were selected. After acclimatization for 14 days, they were divided into base line control (BC, n=11), paracetamol treated control (PC, n=11),Terminalia chebula pretreated and paracetamol treated (TCP-PCT n=11) and paracetamol pretreated and Terminalia chebula treated group (PCP-TCT, n=11). All groups received basal diet for 21 consecutive days. In addition to basal diet, rats of BC received propylene glycol (2ml/kg body weight, orally) and PC received single dose of paracetamol suspension (750mg/kg body weight, orally) on 21st day. Rats of TCP-PCT received Terminalia chebula extract (200 mg/kg body weight, orally) for 21 consecutive days and paracetamol suspension (750mg/kg body weight, orally) on 21st day. Again, rats of PCP-TCT received paracetamol suspension (750mg/kg body weight, orally) on the 1st day and Terminalia chebula extract (200 mg/kg body weight orally) for 21 consecutive days. All rats were sacrificed on 22nd day and then blood samples were collected. For assessment of liver function serum AST and ALT levels were estimated by using standard laboratory kits. The statistical analysis was done by one way ANOVA and post hoc Bonferroni test as applicable.Results: The mean serum AST and ALT levels were significantly (p<0.001) higher in PC in comparison to those of BC. Serum AST and ALT levels of all experimental groups were significantly (P<0.001) lower than PC group. Conclusion: From the results of this study, it may be concluded that Terminalia chebula may have some hepatoprotective effects in paracetamol induced liver damage in rats.Bangladesh Soc Physiol. 2015, June; 10(1): 1-5

Sources of Error in Spectrophotometric Measurement of Aspartate Aminotransferase and Alanine Aminotransferase Activities in Serum

1974 ◽  
Vol 20 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Denis O Rodgerson ◽  
Iris M Osberg
Keyword(s):  
Enzyme Activity ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Short Interval ◽  
Error Sources ◽  
Double Beam ◽  
Serum Aspartate Aminotransferase ◽  
Endogenous Substrate ◽  
Coupled Reactions ◽  
Serum Glutamate

Abstract We examined the measurement of serum aspartate and alanine aminotransferase activities with a short-interval enzyme-activity analyzer. Double-beam spectrophotometry was used to elucidate the source of errors in such measurements. For both enzymes the principal error sources are: (a) the presence of endogenous substrate for lactate dehydrogenase, and (b) reaction of 2-oxoglutarate with serum glutamate dehydrogenase and ammonium ions added to the reaction mixture in admixture with the secondary enzymes of the coupled reactions. In the case of serum aspartate aminotransferase, a less important source of error is the reaction of serum alanine aminotransferase with endogenous substrate. Use of 2-oxoglutarate as a reaction initiator in conventional methods causes errors. Suitable blank reagent mixtures are described that permit accurate, rapid measurement of these activities by double-beam spectrophotometry in a short-interval enzyme-activity analyzer.

Toxicological Interactions of Cassia Senna and Nerium oleander in the Diet of Rats

2002 ◽  
Vol 30 (04) ◽  
pp. 579-587 ◽  
Author(s):  
M. A. Al-Yahya ◽  
A. H. Al-Farham ◽  
S. E. I. Adam
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Total Protein ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Wistar Rats ◽  
Feed Utilization ◽  
Nerium Oleander ◽  
Serum Aspartate Aminotransferase ◽  
Male Wistar Rats

The toxic effects of diet containing 10% of C. senna L. fruits or 10% of N. oleander L. leaves or their 1 : 1 mixture (5%+5%) on male Wistar rats treated for 6 weeks were investigated. Diarrhea was a prominent sign of C. senna L. toxicosis. In both phytotoxicities, there were decreases in body weight gains, inefficiency of feed utilization, dullness and enterohepatonephropathy. These findings accompanied by leukopenia and anemia were correlated with alterations of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities and concentrations of total protein, albumin, urea and other serum constituents. In both phytotoxicities, the ability of the liver to excrete bilirubin remained unchanged. Feeding the mixture of C. senna L. fruits and N. oleander L. leaves caused more serious effects and death of rats. The implications of these findings are discussed.

scholarly journals Effects of various levels of dietary Artemisia abyssinica leaves on rats

2000 ◽  
Vol 34 (3) ◽  
pp. 307-312 ◽  
Author(s):  
S. E. I. Adam ◽  
A. A. Al-Qarawi ◽  
E. A. Elhag
Keyword(s):  
Traditional Medicine ◽  
Total Protein ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Wistar Rats ◽  
Standard Diet ◽  
Gamma Glutamyl Transferase ◽  
Serum Aspartate Aminotransferase ◽  
Male Wistar Rats ◽  
Glutamyl Transferase

Artemisia abyssinica leaves, a traditional medicine for the treatment of various disorders, were fed to male Wistar rats at 2% and 10% of the standard diet for 6 weeks. A 2% A. abyssinica leaf diet was not toxic to rats. Depression in growth, hepatopathy and nephropathy were observed in rats fed a diet containing 10% of A. abyssinica leaves. These findings were accompanied by leukopenia, anaemia and alterations of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) activities with changes in concentrations of total protein, albumin, cholesterol and urea.

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