scholarly journals Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis

2020 ◽  
Vol 4 (5) ◽  
pp. 696-707 ◽  
Author(s):  
Wojciech Swiatek ◽  
K. Mark Parnell ◽  
G. Allen Nickols ◽  
Bruce F. Scharschmidt ◽  
Jared Rutter
Keyword(s):  
Fatty Acid ◽  
Nonalcoholic Steatohepatitis ◽  
Therapeutic Target ◽  
Triglyceride Synthesis ◽  
Hepatic Fatty Acid ◽  
Pas Kinase ◽  
Kinase A

scholarly journals Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis

2014 ◽  
Vol 35 (2) ◽  
pp. 582-590 ◽  
Author(s):  
Kazutoshi Yamada ◽  
Eishiro Mizukoshi ◽  
Hajime Sunagozaka ◽  
Kuniaki Arai ◽  
Tatsuya Yamashita ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatic Fatty Acid ◽  
Fatty Acid Compositions

scholarly journals Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion

2009 ◽  
Vol 297 (3) ◽  
pp. G567-G575 ◽  
Author(s):  
Srinivasan Dasarathy ◽  
Takhar Kasumov ◽  
John M. Edmison ◽  
Lourdes L. Gruca ◽  
Carole Bennett ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Nonalcoholic Steatohepatitis ◽  
Acid Oxidation ◽  
Specific Rate ◽  
Urea Synthesis ◽  
Hepatic Fatty Acid ◽  
Fractional Contribution ◽  
Significant Difference ◽  
Hepatic Fatty Acid Oxidation

The rates of oxidation of glycine and ureagenesis were quantified in the basal state and in response to an intravenous infusion of intralipid with heparin (IL) in healthy subjects ( n = 8) and in subjects with nonalcoholic steatohepatitis (NASH) ( n = 6). During fasting, no significant difference in weight-specific rate of appearance ( Ra) of glycine, glycine oxidation, and urea synthesis was observed. Intralipid infusion resulted in a significant increase in plasma β-hydroxybutyrate in both groups. The correlation between free fatty acids and β-hydroxybutyrate concentration in plasma was 0.94 in NASH compared with 0.4 in controls, indicating greater hepatic fatty acid oxidation in NASH. Intralipid infusion resulted in a significant decrease in urea synthesis and glycine Rain both groups and did not impact glycine oxidation. The fractional contribution of glycine carbon to serine was lower in subjects with NASH before and after IL infusion. In contrast, the fractional contribution of serine carbon to cystathionine was higher in NASH before and following IL infusion. These results suggest that hepatic fatty acid oxidation is higher in NASH compared with controls and that glycine oxidation and urea synthesis are not altered. An increase in oxidative stress, induced by a higher rate of fatty acid oxidation in NASH, may have caused an increase in the contribution of serine to cystathionine to meet the higher demands for glutathione.

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