Impact of Immune Response on Outcomes in Hepatocellular Carcinoma: Association With Vascular Formation

Hepatology ◽  
2020 ◽  
Vol 72 (6) ◽  
pp. 1987-1999 ◽  
Author(s):  
Shinji Itoh ◽  
Tomoharu Yoshizumi ◽  
Kyohei Yugawa ◽  
Daisuke Imai ◽  
Shohei Yoshiya ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Vascular Formation

scholarly journals Clinical Significance of Polymorphisms in Immune Response Genes in Hepatitis C-Related Hepatocellular Carcinoma

2019 ◽  
Vol 10 ◽  
Author(s):  
Valli De Re ◽  
Maria Lina Tornesello ◽  
Mariangela De Zorzi ◽  
Laura Caggiari ◽  
Francesca Pezzuto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Hepatitis C ◽  
Clinical Significance ◽  
Immune Response Genes

scholarly journals Transgenic Technology and the Study of Hepatitis Viruses: A Review of What We Have Learned

2000 ◽  
Vol 14 (9) ◽  
pp. 781-787 ◽  
Author(s):  
David R Milich
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Transgenic Technology ◽  
Gene Expression And Regulation ◽  
Hepatitis Viruses ◽  
Hbv Replication ◽  
Viral Genes

Because of the absence of inbred animal models susceptible to infection by the hepatitis B (HBV), C (HCV) and delta (HDV) viruses, and the inability to culture these viruses, a number of investigators have produced transgenic (Tg) mice that express one or all the viral genes. This review attempts to catalogue and characterize the Tg mice produced to date. The topics addressed are HBV, HCV and HDV gene expression and regulation; HBV replication models and factors that inhibit replication; HBV pathogenesis models; HBV tolerance and persistence models; modulation of the immune response to HBV proteins in Tg mice; T cell receptor Tg mice; and models of hepatocellular carcinoma.

scholarly journals Newer molecules and new hopes in the management of chronic hepatitis C

JMS SKIMS ◽  
2010 ◽  
Vol 13 (2) ◽  
pp. 39-40
Author(s):  
Showkat Ali Zargar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Liver Transplantation ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Chronic Infection ◽  
Antiviral Therapies ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Chronic hepatitis C is highly prevalent with prevalence rate of around 3% involving about 180 million people worldwide, despite major advances in its understanding of viral 1 pathogenesis and significant evolution in antiviral therapies. Most of the patients develop chronic infection because the virus evades the host immune response in majority of patients. Chronic HCV infection can lead to cirrhosis and hepatocellular carcinoma. Complications of HCV-related cirrhosis are the leading indication for liver transplantation in United States and Europe...... J Med Sci 2010;13(2): 39-40.

Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma

2020 ◽  
Vol 73 ◽  
pp. S375
Author(s):  
David J. Pinato ◽  
Takahiro Kaneko ◽  
Alejandro Forner ◽  
Beatriz Minguez ◽  
Edoardo Giovanni Giannini ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Anti Cancer

scholarly journals Immunological Basis of Genesis of Hepatocellular Carcinoma: Unique Challenges and Potential Opportunities through Immunomodulation

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 247 ◽  
Author(s):  
Kumar Jayant ◽  
Nagy Habib ◽  
Kai W. Huang ◽  
Mauro Podda ◽  
Jane Warwick ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Checkpoint Inhibitors ◽  
Contemporary Literature ◽  
Tumour Microenvironment ◽  
Vital Role ◽  
Immunological Mechanisms ◽  
Intent To Treat ◽  
In Situ Vaccine

A majority of hepatocellular carcinoma (HCC) develops in the setting of persistent chronic inflammation as immunological mechanisms have been shown to play a vital role in the initiation, growth and progression of tumours. The index review has been intended to highlight ongoing immunological changes in the hepatic parenchyma responsible for the genesis and progression of HCC. The in-situ vaccine effect of radiofrequency (RF) is through generation tumour-associated antigens (TAAs), following necrosis and apoptosis of tumour cells, which not only re-activates the antitumour immune response but can also act in synergism with checkpoint inhibitors to generate a superlative effect with intent to treat primary cancer and distant metastasis. An improved understanding of oncogenic responses of immune cells and their integration into signaling pathways of the tumour microenvironment will help in modulating the antitumour immune response. Finally, we analyzed contemporary literature and summarised the recent advances made in the field of targeted immunotherapy involving checkpoint inhibitors along with RF application with the intent to reinstate antitumour immunity and outline future directives in very early and early stages of HCC.

scholarly journals Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e72411 ◽  
Author(s):  
Yunzhong Nie ◽  
Yueqiu Chen ◽  
Yongbin Mou ◽  
Leihua Weng ◽  
Zhenjun Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Magnetic Fields ◽  
Low Frequency ◽  
Antitumor Immune Response
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