Molecular Predictors Associated with Immune Response for Occurrence and Prognosis of Hepatocellular Carcinoma: Model Development and Validation

2020 ◽  
Author(s):  
Guanjun Liu ◽  
Dongmei Wu ◽  
Yiyang Wen ◽  
Jie Ping ◽  
Shundong Cang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Model Development ◽  
Development And Validation

scholarly journals Preoperative Risk Stratification for Early Recurrence of HBV-related Hepatocellular Carcinoma After Deceased Donor Liver Transplantation:A Five-Eight Model Development and Validation

2019 ◽  
Author(s):  
Abdulahad Abdulrab Mohammed Al-Ameri ◽  
Xuyong Wei ◽  
Lidan Lin ◽  
Zhou Shao ◽  
Haijun Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Model Development ◽  
Deceased Donor ◽  
Early Recurrence ◽  
Individual Risk ◽  
Tumor Diameter ◽  
Tumor Number ◽  
Serum Alpha Fetoprotein ◽  
Transplant Registry ◽  
Development And Validation

Abstract Background: Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. This study aims to construct a preoperative model to predict individual risk of post-LT HCC recurrence. Methods: Data of 748 adult patients who underwent deceased donor LT for HCC between January 2015, and February 2019 were collected retrospectively from the China Liver Transplant Registry database and randomly divided into training (n=486) and validation(n=262) cohorts. A multivariate analysis was performed and the five-eight model was developed. Results: A total of 748 patients were included in the study; of them, 96% had hepatitis B virus (HBV) and 84 % had cirrhosis. Pre-LT serum alpha-fetoprotein (AFP), tumor number and largest tumor diameter were incorporated to construct the 5-8 model which can stratify patients accurately according to their risk of recurrence into three prognostic subgroups; low-(0-5 points), medium-(6–8 points) and high-risk (>8 points) with 2-year post-LT recurrence rate of (5%,20% and 51%,p<0.001) respectively.The 5-8 model was better than Milan, Hangzhou, and AFP-model for prediction of HCC early recurrence. These findings were confirmed by the results of the validation cohort. Conclusions: The 5-8 model is a simple validated and accurate tool for preoperative stratification of early recurrence of HCC after LT.

scholarly journals Preoperative risk stratification for early recurrence of HBV-related hepatocellular carcinoma after deceased donor liver transplantation: a five-eight model development and validation

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Abdulahad Abdulrab Mohammed Al-Ameri ◽  
Xuyong Wei ◽  
Lidan Lin ◽  
Zhou Shao ◽  
Haijun Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Model Development ◽  
Deceased Donor ◽  
Early Recurrence ◽  
Individual Risk ◽  
Tumor Diameter ◽  
Donor Liver Transplantation ◽  
Serum Alpha Fetoprotein ◽  
Development And Validation

Abstract Background Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. This study aims to construct a preoperative model to predict individual risk of post-LT HCC recurrence. Methods Data of 748 adult patients who underwent deceased donor LT for HCC between January 2015, and February 2019 were collected retrospectively from the China Liver Transplant Registry database and randomly divided into training (n = 486) and validation(n = 262) cohorts. A multivariate analysis was performed and the five-eight model was developed. Results A total of 748 patients were included in the study; of them, 96% had hepatitis B virus (HBV) and 84% had cirrhosis. Pre-LT serum alpha-fetoprotein (AFP), tumor number and largest tumor diameter were incorporated to construct the 5–8 model which can stratify patients accurately according to their risk of recurrence into three prognostic subgroups; low-(0–5 points), medium-(6–8 points) and high-risk (> 8 points) with 2-year post-LT recurrence rate of (5,20 and 51%,p <  0.001) respectively. The 5–8 model was better than Milan, Hangzhou, and AFP-model for prediction of HCC early recurrence. These findings were confirmed by the results of the validation cohort. Conclusions The 5–8 model is a simple validated and accurate tool for preoperative stratification of early recurrence of HCC after LT.

scholarly journals Preoperative Risk Stratification for Early Recurrence of HBV-related Hepatocellular Carcinoma After Deceased Donor Liver Transplantation:A Five-Eight Model Development and Validation

2019 ◽  
Author(s):  
Abdulahad Abdulrab Mohammed Al-Ameri ◽  
Xuyong Wei ◽  
Lidan Lin ◽  
Zhou Shao ◽  
Haijun Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Model Development ◽  
Deceased Donor ◽  
Early Recurrence ◽  
Individual Risk ◽  
Tumor Diameter ◽  
Tumor Number ◽  
Serum Alpha Fetoprotein ◽  
Transplant Registry ◽  
Development And Validation

Abstract Background Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. Objectives To construct a preoperative model to predict individual risk of post-LT HCC recurrence. Methods Data of 748 adult patients who underwent deceased donor LT for HCC between January 2015, and February 2019 were collected retrospectively from the China Liver Transplant Registry database and randomly divided into training (n=486) and validation(n=262) cohorts. A multivariate analysis was performed and the five-eight model was developed. Results A total of 748 patients were included in the study; of them, 96% had hepatitis B virus (HBV) and 84 % had cirrhosis. Pre-LT serum alpha-fetoprotein (AFP), tumor number and largest tumor diameter were incorporated to construct the 5-8 model which can stratify patients accurately according to their risk of recurrence into three prognostic subgroups; low-(0-5 points), medium-(6–8 points) and high-risk (>8 points) with 2-year post-LT recurrence rate of (5%,20% and 51%,p<0.001) respectively.The 5-8 model was better than Milan, Hangzhou, and AFP-model for prediction of HCC early recurrence. These findings were confirmed by the results of the validation cohort. Conclusions The 5-8 model is a simple validated and accurate tool for preoperative stratification of early recurrence of HCC after LT.

scholarly journals Preoperative Risk Stratification for Early Recurrence of HBV-related Hepatocellular Carcinoma After Deceased Donor Liver Transplantation:A Five-Eight Model Development and Validation

2019 ◽  
Author(s):  
Abdulahad Abdulrab Mohammed Al-Ameri ◽  
Xuyong Wei ◽  
Lidan Lin ◽  
Zhou Shao ◽  
Haijun Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Model Development ◽  
Deceased Donor ◽  
Early Recurrence ◽  
Individual Risk ◽  
Tumor Diameter ◽  
Tumor Number ◽  
Serum Alpha Fetoprotein ◽  
Transplant Registry ◽  
Development And Validation

Abstract Background Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. Objectives To construct a preoperative model to predict individual risk of post-LT HCC recurrence. Methods Data of 748 adult patients who underwent deceased donor LT for HCC between January 2015, and February 2019 were collected retrospectively from the China Liver Transplant Registry database and randomly divided into training (n=486) and validation(n=262) cohorts. A multivariate analysis was performed and the five-eight model was developed. Results A total of 748 patients were included in the study; of them, 96% had hepatitis B virus (HBV) and 84 % had cirrhosis. Pre-LT serum alpha-fetoprotein (AFP), tumor number and largest tumor diameter were incorporated to construct the 5-8 model which can stratify patients accurately according to their risk of recurrence into three prognostic subgroups; low-(0-5 points), medium-(6–8 points) and high-risk (>8 points) with 2-year post-LT recurrence rate of (5%,20% and 51%,p<0.001) respectively.The 5-8 model was better than Milan, Hangzhou, and AFP-model for prediction of HCC early recurrence. These findings were confirmed by the results of the validation cohort. Conclusions The 5-8 model is a simple validated and accurate tool for preoperative stratification of early recurrence of HCC after LT.

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