scholarly journals Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

Hepatology ◽  
2016 ◽  
Vol 63 (4) ◽  
pp. 1272-1286 ◽  
Author(s):  
Ming-Da Wang ◽  
Han Wu ◽  
Gong-Bo Fu ◽  
Hui-Lu Zhang ◽  
Xu Zhou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Coenzyme A ◽  
Acid Synthesis ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Acetyl Coenzyme A Carboxylase

scholarly journals The Role of Pyruvate Dehydrogenase and Acetyl-Coenzyme A Synthetase in Fatty Acid Synthesis in Developing Arabidopsis Seeds

2000 ◽  
Vol 123 (2) ◽  
pp. 497-508 ◽  
Author(s):  
Jinshan Ke ◽  
Robert H. Behal ◽  
Stephanie L. Back ◽  
Basil J. Nikolau ◽  
Eve Syrkin Wurtele ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Pyruvate Dehydrogenase ◽  
Coenzyme A ◽  
Acid Synthesis ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme

scholarly journals A Novel Cold-Sensitive Allele of the Rate-Limiting Enzyme of Fatty Acid Synthesis, Acetyl Coenzyme A Carboxylase, Affects the Morphology of the Yeast Vacuole through Acylation of Vac8p

2000 ◽  
Vol 20 (9) ◽  
pp. 2984-2995 ◽  
Author(s):  
Roger Schneiter ◽  
Cesar E. Guerra ◽  
Manfred Lampl ◽  
Verena Tatzer ◽  
Günther Zellnig ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Protein Targeting ◽  
Coenzyme A ◽  
Acid Synthesis ◽  
Vacuolar Membrane ◽  
Acetyl Coenzyme A ◽  
Rate Limiting ◽  
Acetyl Coenzyme A Carboxylase ◽  
Mutant Cells

ABSTRACT The yeast vacuole functions both as a degradative organelle and as a storage depot for small molecules and ions. Vacuoles are dynamic reticular structures that appear to alternately fuse and fragment as a function of growth stage and environment. Vac8p, an armadillo repeat-containing protein, has previously been shown to function both in vacuolar inheritance and in protein targeting from the cytoplasm to the vacuole. Both myristoylation and palmitoylation of Vac8p are required for its efficient localization to the vacuolar membrane (Y.-X. Wang, N. L. Catlett, and L. S. Weisman, J. Cell Biol. 140:1063–1074, 1998). We report that mutants with conditional defects in the rate-limiting enzyme of fatty acid synthesis, acetyl coenzyme A carboxylase (ACC1), display unusually multilobed vacuoles, similar to those observed in vac8 mutant cells. This vacuolar phenotype of acc1 mutant cells was shown biochemically to be accompanied by a reduced acylation of Vac8p which was alleviated by fatty acid supplementation. Consistent with the proposed defect of acc1 mutant cells in acylation of Vac8p, vacuolar membrane localization of Vac8p was impaired upon shiftingacc1 mutant cells to nonpermissive condition. The function of Vac8p in protein targeting, on the other hand, was not affected under these conditions. These observations link fatty acid synthesis and availability to direct morphological alterations of an organellar membrane.

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