Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1

Hepatology ◽  
2011 ◽  
Vol 54 (6) ◽  
pp. 1956-1965 ◽  
Author(s):  
Richard E. Nettles ◽  
Min Gao ◽  
Marc Bifano ◽  
Ellen Chung ◽  
Anna Persson ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nonstructural Protein ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Replication Complex ◽  
Dose Study ◽  
Nonstructural Protein 5A

scholarly journals In VitroActivity of BMS-790052 on Hepatitis C Virus Genotype 4 NS5A

2011 ◽  
Vol 56 (3) ◽  
pp. 1588-1590 ◽  
Author(s):  
Chunfu Wang ◽  
Lingling Jia ◽  
Haichang Huang ◽  
Dike Qiu ◽  
Lourdes Valera ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nonstructural Protein ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Valuable Component ◽  
Genotype 4 ◽  
Replication Complex ◽  
Hcv Genotype ◽  
Hcv Genotype 1

ABSTRACTThe antiviral profile of BMS-790052, a potent hepatitis C virus (HCV) replication complex inhibitor targeting nonstructural protein NS5A, is well characterized for HCV genotype-1. Here, we report that BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with 50% effective concentrations (EC50s) ranging from 7 to 13 pM. NS5A residue 30 was an important site for BMS-790052-selected resistance in the hybrid replicons. Our results support the potential of BMS-790052 as a valuable component of combination therapy for HCV genotype-4 chronic infection.

scholarly journals Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5a replication complex inhibitor, BMS-790052

Hepatology ◽  
2012 ◽  
Vol 55 (6) ◽  
pp. 1692-1699 ◽  
Author(s):  
Jin-Hua Sun ◽  
Donald R. O'Boyle II ◽  
Yan Zhang ◽  
Chunfu Wang ◽  
Peter Nower ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nonstructural Protein ◽  
Replication Complex ◽  
Emergence Of Resistance ◽  
Nonstructural Protein 5A

scholarly journals A randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4

2014 ◽  
Vol 60 (5) ◽  
pp. 920-927 ◽  
Author(s):  
Bradley Vince ◽  
John M. Hill ◽  
Eric J. Lawitz ◽  
William O’Riordan ◽  
Lynn R. Webster ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Multiple Dose ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Double Blind ◽  
Ns5a Inhibitor ◽  
Multiple Dose Study ◽  
Dose Study

scholarly journals Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection

Hepatology ◽  
1999 ◽  
Vol 30 (4) ◽  
pp. 1045-1053 ◽  
Author(s):  
Takeshi Murakami ◽  
Nobuyuki Enomoto ◽  
Masayuki Kurosaki ◽  
Namiki Izumi ◽  
Fumiaki Marumo ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nonstructural Protein ◽  
Virus Genotype ◽  
Genotype 2 ◽  
Nonstructural Protein 5A

Nonstructural protein 5A/P32 deletion after failure of ledipasvir/sofosbuvir in hepatitis C virus genotype 1b infection

Hepatology ◽  
2018 ◽  
Vol 68 (1) ◽  
pp. 380-383 ◽  
Author(s):  
Akira Doi ◽  
Hayato Hikita ◽  
Ryotaro Sakamori ◽  
Yuki Tahata ◽  
Yugo Kai ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nonstructural Protein ◽  
Virus Genotype ◽  
Genotype 1B ◽  
Nonstructural Protein 5A
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