scholarly journals Serum hepatitis B surface antigen and hepatitis B e antigen titers: Disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers

Hepatology ◽  
2010 ◽  
Vol 51 (6) ◽  
pp. 1933-1944 ◽  
Author(s):  
Alexander J.V. Thompson ◽  
Tin Nguyen ◽  
David Iser ◽  
Anna Ayres ◽  
Kathy Jackson ◽  
...  
Keyword(s):  
Viral Load ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Serum Hepatitis ◽  
Hepatitis B E Antigen ◽  
B Virus ◽  
Hepatitis B Virus Markers

Serum hepatitis B surface antigen monitoring in long-term lamivudine-treated hepatitis B virus patients

2011 ◽  
Vol 18 (10) ◽  
pp. e468-e474 ◽  
Author(s):  
A. Gramenzi ◽  
E. Loggi ◽  
L. Micco ◽  
C. Cursaro ◽  
S. Fiorino ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Serum Hepatitis ◽  
B Virus

scholarly journals Hepatitis B Surface Antigen Levels Can Be Used to Rule Out Cirrhosis in Hepatitis B e Antigen-Positive Chronic Hepatitis B: Results From the SONIC-B Study

2020 ◽  
Author(s):  
Milan J Sonneveld ◽  
Bettina E Hansen ◽  
Willem P Brouwer ◽  
Henry L-Y Chan ◽  
Teerha Piratvisuth ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Hepatitis B E Antigen ◽  
Significant Fibrosis ◽  
B Virus ◽  
Rule Out

Abstract Background Serum hepatitis B surface antigen (HBsAg) levels correlate with the duration of chronic hepatitis B virus (HBV) infection and may predict the extent of hepatic fibrosis. Methods We analyzed data from the SONIC-B database, which contains data from 8 global randomized trials and 2 large hepatology centers. Relationship between HBsAg levels and presence of significant fibrosis (Ishak 3–4) or cirrhosis (Ishak 5–6) were explored, and clinically relevant cutoffs were identified to rule out cirrhosis. Results The dataset included 2779 patients: 1866 hepatitis B e antigen (HBeAg)-positive; 322 with cirrhosis. Among HBeAg-positive patients, lower HBsAg levels were associated with higher rates of significant fibrosis (odds ratio [OR], 0.419; P < .001) and cirrhosis (OR, 0.435; P < .001). No relationship was observed among HBeAg-negative patients. Among HBeAg-positive patients, genotype-specific HBsAg cutoffs had excellent negative predictive values (>97%) and low misclassification rates (≤7.1%) and may therefore have utility in ruling out cirrhosis. Diagnostic performance of the HBsAg cutoffs was comparable among patients in whom cirrhosis could not be ruled out with fibrosis 4 (FIB-4). Conclusions Hepatitis B virus genotype-specific HBsAg cutoffs may have utility in ruling out presence of cirrhosis in HBeAg-positive patients with genotypes B, C, and D and can be an adjunct to FIB-4 to reduce the need for further testing.

Hepatitis B virus DNA viral load determination in hepatitis B surface antigen-negative Swiss blood donors

Transfusion ◽  
2014 ◽  
Vol 54 (11) ◽  
pp. 2961-2967 ◽  
Author(s):  
Martin Stolz ◽  
Caroline Tinguely ◽  
Stefano Fontana ◽  
Christoph Niederhauser
Keyword(s):  
Viral Load ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Hepatitis B Virus Dna ◽  
B Virus ◽  
Viral Load Determination

Possible transmission of hepatitis B virus between spouses and their children in Babol, Northern Iran

2007 ◽  
Vol 37 (4) ◽  
pp. 245-247 ◽  
Author(s):  
Mohammad Reza Hasanjani Roushan ◽  
Minoo Mohraz ◽  
Ali Akbar Velayati
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Family Members ◽  
Hbv Infection ◽  
Hepatitis B E Antigen ◽  
Northern Iran ◽  
Hbv Markers ◽  
B Virus

To determine the possible routes of transmission of hepatitis B virus (HBV) infection between spouses and their children in Babol, Northern Iran, the spouses of 54 infected husbands and 49 wives without any evidence of HBV infection in their family members were evaluated from March 1998 to April 2005. All of these cases were hepatitis B surface antigen and anti-hepatitis B 'e' antigen positive. Mean duration of marriage for husbands was 14.4±6.49 and for wives12.46±6.24 years. Past HBV infection was found in 46.3% wives of infected husbands and in 65.3% husbands of infected wives ( P = 0.074). HBV markers were seen in 32.5% children of infected fathers and 64.5% children of infected mothers ( P = 0.0001). HBV carrier rates in boys and girls of infected mothers were significantly higher than in those of infected fathers ( P = 0.002 and P = 0.0001, respectively). The results show that transmission of HBV between spouses and their children were the main routes of transmission of HBV in our region.

scholarly journals HEPATITIS B VIRUS

2007 ◽  
Vol 14 (02) ◽  
pp. 241-247
Author(s):  
JIANBO XIAO ◽  
Lei Zhang ◽  
XIAOQING CHEN ◽  
Ming Xu * ◽  
XINYU JIANG
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepg2 Cells ◽  
Morphological Changes ◽  
Hepatitis B Surface Antigen ◽  
Hbv Dna ◽  
Hepatitis B E Antigen ◽  
B Virus ◽  
Clone Cells

Dried leaves of Marchantia convoluta are largely used to protect livers,and to treat tumefaction of skins in China. Flavonoids from Marchantia Convoluta (MCF) was one of the mostpotentially effective anti-inflammatory. MCF was studied here for its ability to inhibit the proliferation of 2,2,15 cells(clone cells derived from HepG2 cells that were transected with a plasmid containing HBV, DNA). All concentrations(5,10,20 and 40 :g/ml) of MCF inhibit hepatitis B surface antigen (HbsAg) and hepatitis B E antigen (HbeAg) in thecultured medium released from 2.2.15 cells. Analysis of morphological changes of MCF-treated phase- contrastmicroscope revealed a possible model of action for MCF to inhibit Proliferation of 2.2.15 cells by inducing apoptosis.

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