Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells

Hepatology ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 1130-1139 ◽  
Author(s):  
Mona Malz ◽  
Achim Weber ◽  
Stephan Singer ◽  
Vera Riehmer ◽  
Michaela Bissinger ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Binding Proteins ◽  
Liver Cancer Cells ◽  
Upstream Element ◽  
And Migration ◽  
Proliferation And Migration

Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells

2011 ◽  
Vol 55 (5) ◽  
pp. 1049-1057 ◽  
Author(s):  
Antje Brauckhoff ◽  
Mona Malz ◽  
Darjus Tschaharganeh ◽  
Nisar Malek ◽  
Achim Weber ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Liver Cancer Cells ◽  
Nuclear Expression ◽  
Seven In Absentia ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Effect of lncRNA‑BC200 on proliferation and migration of liver cancer cells in�vitro and in�vivo

2019 ◽  
Author(s):  
Ni Tan ◽  
Bo Zhu ◽  
Hong Shu ◽  
Yi‑Feng Tao ◽  
Jun‑Rong Wu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94440-94449 ◽  
Author(s):  
Hongyang Yu ◽  
Ruichun Jia ◽  
Ling Zhao ◽  
Shigang Song ◽  
Jing Gu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Effects of propofol on the proliferation and migration of liver cancer cells

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Chan Li ◽  
Qingxia Fu ◽  
Jin Cai ◽  
Hongxia Mei ◽  
Wangning Shangguan
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

Abstract 2157: PI3K/AKT-induced stabilization of FUSE binding proteins (FBPs) in liver cancer cells

2015 ◽  
Author(s):  
Jana Samarin ◽  
Ilan Stein ◽  
Elad Horwitz ◽  
Xin Chen ◽  
Mona Malz ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Binding Proteins ◽  
Liver Cancer Cells

scholarly journals Downregulation of PITX2 inhibits the proliferation and migration of liver cancer cells and induces cell apoptosis

2021 ◽  
Vol 16 (1) ◽  
pp. 1322-1329
Author(s):  
Kebinuer Tuerxun ◽  
Shufang Zhang ◽  
Yuexin Zhang
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Cell Apoptosis ◽  
Migration And Invasion ◽  
Liver Cancer Cell ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Pitx2 Expression

Abstract Paired-like homeodomain 2 (PITX2) functions as a transcription factor to participate in vertebrate embryogenesis, and dysregulated PITX2 expression was associated with the progression of various cancers. The functional role of PITX2 in tumorigenesis of liver cancer remains unknown. Western blot analysis showed that expression levels of PITX2 were enhanced in the liver cancer tissues and cells. siRNAs targeting PITX2 induced downregulation of PITX2 in liver cancer cells. siRNA-induced knockdown of PITX2 decreased liver cancer cell viability and proliferation, while promoting cell apoptosis by increasing cleaved-PARP, cleaved caspase 3, and cleaved caspase 9. The knockdown of PITX2 repressed liver cancer cell migration and invasion. In conclusion, elevated PITX2 expression was associated with liver cancer progression through repression of cell apoptosis and promoting cell proliferation and metastasis, and silencing of PITX2 might serve as a potential therapeutic strategy for the treatment of liver cancer.

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