scholarly journals Effect of lncRNA‑BC200 on proliferation and migration of liver cancer cells in�vitro and in�vivo

2019 ◽  
Author(s):  
Ni Tan ◽  
Bo Zhu ◽  
Hong Shu ◽  
Yi‑Feng Tao ◽  
Jun‑Rong Wu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells In Vitro and In Vivo

2014 ◽  
Vol 20 (5) ◽  
pp. 1274-1287 ◽  
Author(s):  
Chun-Han Chen ◽  
Mei-Chuan Chen ◽  
Jing-Chi Wang ◽  
An-Chi Tsai ◽  
Ching-Shih Chen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Hdac Inhibitor ◽  
Synergistic Interaction ◽  
Liver Cancer Cells

Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells

2011 ◽  
Vol 55 (5) ◽  
pp. 1049-1057 ◽  
Author(s):  
Antje Brauckhoff ◽  
Mona Malz ◽  
Darjus Tschaharganeh ◽  
Nisar Malek ◽  
Achim Weber ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Liver Cancer Cells ◽  
Nuclear Expression ◽  
Seven In Absentia ◽  
And Migration ◽  
Proliferation And Migration

Growth inhibitory effects of pegylated IFN ?-2b on human liver cancer cells in vitro and in vivo

2006 ◽  
Vol 26 (8) ◽  
pp. 964-975 ◽  
Author(s):  
Hirohisa Yano ◽  
Sachiko Ogasawara ◽  
Seiya Momosaki ◽  
Jun Akiba ◽  
Sakiko Kojiro ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Inhibitory Effects ◽  
Liver Cancer Cells ◽  
Growth Inhibitory ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

scholarly journals Myrrh induces the apoptosis and inhibits the proliferation and migration of gastric cancer cells through down-regulating cyclooxygenase-2 expression

2020 ◽  
Vol 40 (5) ◽  
Author(s):  
Mengxue Sun ◽  
Jie Hua ◽  
Gaoshuang Liu ◽  
Peiyun Huang ◽  
Ningsheng Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cellular Proliferation ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Cox 2 ◽  
And Migration ◽  
Proliferation And Migration

Abstract Objective: The present study is designed to evaluate the anti-tumor effects of myrrh on human gastric cancer both in vitro and in vivo. Methods: The gastric cancer cell proliferation was determined by MTT assay. Apoptosis was measured by flow cytometry and Hoechst 33342 staining. Wound healing was performed to evaluate the effects of myrrh on the migration. COX-2, PCNA, Bcl-2, and Bax expressions were detected by Western blot analysis. A xenograft nude mice model of human gastric cancer was established to evaluate the anti-cancer effect of myrrh in vivo. Results: Myrrh significantly inhibited cellular proliferation, migration, and induced apoptosis in vitro as well as inhibited tumor growth in vivo. In addition, myrrh inhibited the expression of PCNA, COX-2, and Bcl-2 as well as increased Bax expression in gastric cancer cells. Conclusion: Myrrh may inhibit the proliferation and migration of gastric cancer cells, as well as induced their apoptosis by down-regulating the expression of COX-2.

scholarly journals Ascorbic Acid Inhibits Liver Cancer Growth and Metastasis in vitro and in vivo, Independent of Stemness Gene Regulation

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingjing Wan ◽  
Juan Zhou ◽  
Lu Fu ◽  
Yubin Li ◽  
Huawu Zeng ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Gene Regulation ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Liver Cancer Cells ◽  
Induced Apoptosis ◽  
Xenotransplantation Model

Experimental and clinical evidence has indicated that the natural product ascorbic acid (AA) is effective in preventing and treating various types of cancers. However, the effect of AA on liver cancer metastasis has not yet been reported. Cancer stem cells (CSCs) play pivotal roles in cancer metastasis. Here, we demonstrated that AA selectively inhibited the viability of both liver cancer cells and CSCs, reduced the formation of cancer cell colonies and CSC spheres, and inhibited tumor growth in vivo. Additionally, AA prevented liver cancer metastasis in a xenotransplantation model without suppressing stemness gene expression in liver CSCs. Further study indicated that AA increased the concentration of H2O2 and induced apoptosis in liver CSCs. Catalase attenuated the inhibitory effects of AA on liver CSC viability. In conclusion, AA inhibited the viability of liver CSCs and the growth and metastasis of liver cancer cells in vitro and in vivo by increasing the production of H2O2 and inducing apoptosis. Our findings provide evidence that AA exerts its anti-liver cancer efficacy in vitro and in vivo, in a manner that is independent of stemness gene regulation.

The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo

2012 ◽  
Vol 324 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Evandro Fei Fang ◽  
Chris Zhi Yi Zhang ◽  
Jack Ho Wong ◽  
Jia Yun Shen ◽  
Chuan Hao Li ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Momordica Charantia ◽  
Bitter Gourd ◽  
Liver Cancer Cells

scholarly journals LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94440-94449 ◽  
Author(s):  
Hongyang Yu ◽  
Ruichun Jia ◽  
Ling Zhao ◽  
Shigang Song ◽  
Jing Gu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration
Sign in / Sign up

Export Citation Format

Share Document