scholarly journals Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma

Hepatology ◽  
2009 ◽  
Vol 50 (1) ◽  
pp. 102-112 ◽  
Author(s):  
Marco Breinig ◽  
Eloisi Caldas-Lopes ◽  
Benjamin Goeppert ◽  
Mona Malz ◽  
Ralf Rieker ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Human Hepatocellular Carcinoma ◽  
Chemotherapeutic Approach

Correlation between Clinicopathology and Immunolocalization of Heat Shock Protein 72 and Glycoprotein 96 in Human Hepatocellular Carcinomas

2011 ◽  
Vol 282-283 ◽  
pp. 3-6
Author(s):  
Xiao Ping Wang ◽  
Huan Ping Lin ◽  
Qiao Xia Wang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lymph Node ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Human Hepatocellular Carcinoma ◽  
Tumor Infiltration ◽  
Heat Shock Protein 72 ◽  
Gastrointestinal Carcinomas ◽  
Hepatocellular Carcinomas ◽  
Cancer Tissues

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 and gp96 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that HSP72 and gp96 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

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