The interleukin-17 pathway is involved in human alcoholic liver disease

Hepatology ◽  
2008 ◽  
Vol 49 (2) ◽  
pp. 646-657 ◽  
Author(s):  
Arnaud Lemmers ◽  
Christophe Moreno ◽  
Thierry Gustot ◽  
Raphaël Maréchal ◽  
Delphine Degré ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Interleukin 17 ◽  
Human Alcoholic

Conservation of whole body nitric oxide metabolism in human alcoholic liver disease: Implications for nitric oxide production

2006 ◽  
Vol 41 (7) ◽  
pp. 820-825 ◽  
Author(s):  
Eric A. G. Demoncheaux ◽  
David A. Elphick ◽  
Marc B. Dürner ◽  
Gail E. Higgins ◽  
David Crowther ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Whole Body ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Nitric Oxide Metabolism ◽  
Human Alcoholic

Changes of hepatic microtubules and secretory proteins in human alcoholic liver disease

1983 ◽  
Vol 18 ◽  
pp. 479-482 ◽  
Author(s):  
Yoshiro Matsuda ◽  
Akira Takada ◽  
Ryuichi Kanayama ◽  
Shujiro Takase
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Secretory Proteins ◽  
Human Alcoholic

Disturbed intracellular calcium-related processes of hepatocytes and neutrophils in human alcoholic liver disease

1990 ◽  
Vol 23 (3) ◽  
pp. 241-245 ◽  
Author(s):  
György Baffy ◽  
Zsuzsa Varga ◽  
Gabriella Fóris ◽  
András Leövey
Keyword(s):  
Liver Disease ◽  
Intracellular Calcium ◽  
Alcoholic Liver Disease ◽  
Human Alcoholic

Pathological significance of oxidative cellular damage in human alcoholic liver disease

2003 ◽  
Vol 42 (4) ◽  
pp. 365-371 ◽  
Author(s):  
S Seki ◽  
T Kitada ◽  
H Sakaguchi ◽  
K Nakatani ◽  
K Wakasa
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Cellular Damage ◽  
Human Alcoholic

Increased S-Adenosylhomocysteine (SAH) May Predispose to TNF Liver Injury in Human Alcoholic Liver Disease (ALD)

2005 ◽  
Vol 100 ◽  
pp. S143
Author(s):  
Jonathan W. Goldstein ◽  
Theresa Chen ◽  
Rehan Khan ◽  
Jennifer Lanter ◽  
Shirish Barve ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Alcoholic Liver Disease ◽  
Human Alcoholic

scholarly journals Anti-IL-17 Antibody Improves Hepatic Steatosis by Suppressing Interleukin-17-Related Fatty Acid Synthesis and Metabolism

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Weidong Shi ◽  
Qiang Zhu ◽  
Jian Gu ◽  
Xiaoshan Liu ◽  
Ling Lu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Liver Disease ◽  
Hepatic Steatosis ◽  
Fatty Acid Metabolism ◽  
Alcoholic Liver Disease ◽  
Acid Metabolism ◽  
Binding Protein ◽  
Interleukin 17 ◽  
Expression Levels ◽  
Element Binding Protein

To investigate the relationship between interleukin-17 and proteins involved in fatty acid metabolism with respect to alcoholic liver disease, male ICR mice were randomized into five groups: control, alcoholic liver disease (ALD) at 4 weeks, 8 weeks, and 12 weeks, and anti-IL-17 antibody treated ALD. A proteomic approach was adopted to investigate changes in liver proteins between control and ALD groups. The proteomic analysis was performed by two-dimensional difference gel electrophoresis. Spots of interest were subsequently subjected to nanospray ionization tandem mass spectrometry (MS/MS) for protein identification. Additionally, expression levels of selected proteins were confirmed by western blot. Transcriptional levels of some selected proteins were determined by RT-PCR. Expression levels of 95 protein spots changed significantly (ratio >1.5,P<0.05) during the development of ALD. Sterol regulatory element-binding protein-lc (SREBP-1c), carbohydrate response element binding protein (ChREBP), enoyl-coenzyme A hydratase (ECHS1), and peroxisome proliferator-activated receptor alpha (PPAR-α) were identified by MS/MS among the proteins shown to vary the most; increased IL-17 elevated the transcription of SREBP-1c and ChREBP but suppressed ECHS1 and PPAR-α. The interleukin-17 signaling pathway is involved in ALD development; anti-IL-17 antibody improved hepatic steatosis by suppressing interleukin-17-related fatty acid metabolism.

scholarly journals A Novel Mouse Model of Acute‐on‐Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis

2019 ◽  
Vol 44 (1) ◽  
pp. 87-101
Author(s):  
Shinji Furuya ◽  
Josepmaria Argemi ◽  
Takeki Uehara ◽  
Yuuki Katou ◽  
Derrick E. Fouts ◽  
...  
Keyword(s):  
Liver Disease ◽  
Systems Biology ◽  
Mouse Model ◽  
Alcoholic Liver Disease ◽  
Alcoholic Hepatitis ◽  
Human Alcoholic

Mitochondrial β-oxidation in human alcoholic liver disease

1995 ◽  
Vol 23 (3) ◽  
pp. 497S-497S
Author(s):  
Simon Eaton ◽  
Christopher O. Record ◽  
Kim Bartlett
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Human Alcoholic
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