scholarly journals A Novel Mouse Model of Acute‐on‐Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis

2019 ◽  
Vol 44 (1) ◽  
pp. 87-101
Author(s):  
Shinji Furuya ◽  
Josepmaria Argemi ◽  
Takeki Uehara ◽  
Yuuki Katou ◽  
Derrick E. Fouts ◽  
...  
Keyword(s):  
Liver Disease ◽  
Systems Biology ◽  
Mouse Model ◽  
Alcoholic Liver Disease ◽  
Alcoholic Hepatitis ◽  
Human Alcoholic

scholarly journals Sedum emarginatum and its polysaccharide have a therapeutic effect on alcoholic liver disease in mice

2020 ◽  
Vol 9 (5) ◽  
pp. 308-316
Author(s):  
Gong Yuruo ◽  
◽  
Shi Dujuan ◽  
Wei Kevin Zhang ◽  
Xinzhou Yang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mortality Rate ◽  
Mouse Model ◽  
Fatty Liver ◽  
Therapeutic Effect ◽  
Alcoholic Liver Disease ◽  
Liver Tissue ◽  
Alcoholic Hepatitis ◽  
Alcoholic Fatty Liver ◽  
Crude Polysaccharide

Objective: To explore the therapeutic effect of Sedum emarginatum (SE) and its polysaccharide on alcoholic liver disease. Methods: First, we ground fresh SE to obtain homogenate, and then test the effect of SE on a mouse model of acute alcoholic fatty liver disease (AFLD). Kunming female mice were given intragastric administration of alcohol once every 12 hours to induce AFLD, three times in total, and the mice received ethanol and SE at the same time. The mice were sacrificed 4 hours after the last alcohol administration, and serum and liver were collected for testing. We found that SE was effective and then carried out subsequent experiments. The dried SE powder was extracted under heating and reflux by different polar solvents: petroleum ether, ethyl acetate, methanol and water. The extracting solution were heat and concentrated to obtain an extract. The water part was purified to obtain polysaccharide. We tested the therapeutic effect of each part of SE in a mouse model of early alcoholic hepatitis (AH). Mice were given 5 g/kg of alcohol every 12 hours, a total of 9 times, and lipopolysaccharide (LPS) was injected intraperitoneally at the 36 h and 84 h. After 4 hours of the last gavage, the mice were sacrificed. The serum and liver tissue were used to tested relevant biochemical indexes. Results: SE had a certain reversal effect on the increase of serum triglycerides caused by alcohol, and it had a better effect on the accumulation of lipid droplets in liver tissues. Oil red O staining proved this result. In the second acute experiment, the mortality rate of the animal in the model group was 7/12, and the mortality rate in each treatment group was 1/8, 1/7, 4/8, and 1/8. In all parts, the crude polysaccharide did not significantly reverse the increase of serum triglyceride levels in early AH, but it could significantly alleviate the increase of inflammatory foci and steatosis in liver tissue. The transmission electron microscopy result indicates that the crude polysaccharide component has a certain protective effect on mitochondrial damage caused by alcohol. Conclusion: SE can reduce fatty liver and hyperlipidemia caused by alcohol, and its polysaccharide can reduce liver inflammation in the early alcoholic hepatitis by protecting mitochondron.

Regulatory effect of volatile compounds in fermented alcoholic beverages on gut microbiota and serum metabolism in mouse model

2021 ◽  
Author(s):  
Mei Ji ◽  
Cheng Fang ◽  
Wei Jia ◽  
Hai Du ◽  
Yan Xu
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Volatile Compounds ◽  
Alcoholic Liver Disease ◽  
Alcoholic Beverages ◽  
Regulatory Effect ◽  
Main Risk Factor

Ethanol (EtOH) is the main risk factor for alcoholic liver disease. However, fermented alcoholic beverages contain not only ethanol but also various volatile compounds. Currently, effects of volatile compounds in...

Conservation of whole body nitric oxide metabolism in human alcoholic liver disease: Implications for nitric oxide production

2006 ◽  
Vol 41 (7) ◽  
pp. 820-825 ◽  
Author(s):  
Eric A. G. Demoncheaux ◽  
David A. Elphick ◽  
Marc B. Dürner ◽  
Gail E. Higgins ◽  
David Crowther ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Whole Body ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Nitric Oxide Metabolism ◽  
Human Alcoholic

Falling Rates of Hospital Admissions for Alcoholic Liver Disease in Northeast Italy: A Retrospective Study on a Large Database

2019 ◽  
Vol 54 (6) ◽  
pp. 662-666
Author(s):  
Diego Caroli ◽  
Erik Rosa-Rizzotto ◽  
Claudio Pilerci ◽  
Salvatore Lobello ◽  
Franca De Lazzari ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Alcoholic Hepatitis ◽  
Hospital Admissions ◽  
Age Groups ◽  
Veneto Region ◽  
Admission Rates ◽  
Hospitalization Rates ◽  
Acute Alcoholic Hepatitis ◽  
Regional Population

Abstract Aim To describe recent trends in hospital admission rates for alcoholic liver disease (ALD) in the Veneto region of Italy. Methods This retrospective cohort study is based on anonymous hospital discharge records (HDRs) for 2000–2017 from all public and accredited private hospitals operating within the context of the Regional (Veneto) Health Services that are conserved in National/Regional database. It examined the HDR’s of all the hospitalizations of the residents of the Veneto region that were registered under an ALD diagnosis. These were classified under three subheadings: acute alcoholic hepatitis Alcoholic liver cirrhosis and ‘other ALD’. Results During 2000–2017, 30,089 hospital admissions (out of a total regional population of 4,900,000) were registered for ALD. Hospitalization stratified by age showed that the percentage attributable to acute alcoholic hepatitis is higher in younger age groups: 42% in 15–24-year-old (odds ratios (ORs): 14.74; CI95%: 7–30.86; P < 0.000) and 15% in the 25–44-year-old (OR: 3.51; CI95%: 3.12–3.94; P < 0.000). A longitudinal analysis of hospitalization patterns showed a 7% increase in average age in both sexes (from 58.8 ± 9.2 to 62.4 ± 9.7) and a substantial decrease (63.5%) in standardized hospitalization rates (HRs, χ2 trend: 4099.827; P < 0.000) and a smaller decrease (47%) in standardized mortality rates (χ2 trend: 89.563; P < 0.000). Conclusions The fall in the overall ALD-related HR in the Veneto region can be explained by a decrease in population alcohol consumption. Increase in the HRs for acute alcoholic hepatitis in the age group 15–44 suggests an ongoing need for strategies to prevent alcohol abuse by young people.

Changes of hepatic microtubules and secretory proteins in human alcoholic liver disease

1983 ◽  
Vol 18 ◽  
pp. 479-482 ◽  
Author(s):  
Yoshiro Matsuda ◽  
Akira Takada ◽  
Ryuichi Kanayama ◽  
Shujiro Takase
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Secretory Proteins ◽  
Human Alcoholic

Disturbed intracellular calcium-related processes of hepatocytes and neutrophils in human alcoholic liver disease

1990 ◽  
Vol 23 (3) ◽  
pp. 241-245 ◽  
Author(s):  
György Baffy ◽  
Zsuzsa Varga ◽  
Gabriella Fóris ◽  
András Leövey
Keyword(s):  
Liver Disease ◽  
Intracellular Calcium ◽  
Alcoholic Liver Disease ◽  
Human Alcoholic
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