Access to preventive care services and stage at diagnosis in head and neck cancer

Head & Neck ◽  
2020 ◽  
Vol 42 (10) ◽  
pp. 2841-2851
Author(s):  
Douglas R. Farquhar ◽  
Nicholas R. Lenze ◽  
Maheer M. Masood ◽  
Kimon Divaris ◽  
Jason Tasoulas ◽  
...  
Head & Neck ◽  
2015 ◽  
Vol 38 (3) ◽  
pp. 355-363 ◽  
Author(s):  
Carolyn L. Mulvey ◽  
Thomas J. Smith ◽  
Christine G. Gourin

2020 ◽  
Author(s):  
Nosayaba Osazuwa-Peters ◽  
Justin M Barnes ◽  
Eric Adjei Boakye ◽  
Matthew E Gaubatz ◽  
Kenton J Johnston ◽  
...  

2018 ◽  
Vol 4 (Supplement 1) ◽  
pp. 24s-24s
Author(s):  
Renata Abrahao ◽  
Sandra Perdomo ◽  
Luis Kowalski ◽  
Marta Vilensky ◽  
Jose Carlos Oliveira ◽  
...  

Abstract 65 Purpose Incidence of head and neck cancer (HNC) is high in South America, and survival data are scarce in this region. The InterCHANGE study was established by clinical groups from across South America and the International Agency for Research on Cancer, with the primary aim to study the impact of human papillomavirus (HPV) infection and sociodemographic, clinic, and lifestyle factors on survival after this malignancy. The current study examined the main predictors of survival after HNC in South America and estimated overall and conditional survival probabilities. Methods Patients were recruited during 2010 to 2016 from seven centers in Argentina, Brazil, Colombia, and Uruguay. A questionnaire obtained information on age, stage, and body mass index at diagnosis; sex; education; race; and comprehensive smoking and alcohol history. Blood samples were collected for HPV16 E6 testing—a surrogate marker for HPV16 infection. The Kaplan-Meier method and Cox proportional hazards regression were used for statistical analyses. Results Of 1,314 patients, 348 had oropharynx cancer and 966 nonoropharynx cancer (larynx, n = 381; hypopharynx, n = 75; and oral cavity, n = 510). All cases were confirmed by histology or cytology. Most patients were male (81%), of white race (64%), ever smokers (85%), ever drinkers (82%), had a median age at diagnosis of 60 years, and only a basic education (54%). The majority of patients (66%) was diagnosed with stage IV disease, ranging from 53% for larynx to 83% for oropharynx disease. Median follow-up time for patients who died or survived was 0.9 years of 2.3 years, respectively. By October 31, 2017, 628 patients (48%) had died. Three-year overall survival was 53% for larynx, 47% for oral cavity, 40% for oropharynx, and 36% for hypopharynx disease. Main predictors of worse survival were late stage at diagnosis, older age, and underweight (body mass index < 18.5kg/m2) at diagnosis, with some variation according to tumor site. In a subset analysis of 156 patients with oropharynx cancer with available HPV16 E6 serology, those who were negative for HPV16 E6 had significantly lower 3-year survival (27% v 73%), and a corresponding 3.5 times higher mortality rate (adjusted hazard ratio, 3.5; CI, 1.2 to 10.6) than those who were positive for HPV16 E6. Conclusion Most patients presented with strikingly advanced disease, and stage at diagnosis was an important predictor of survival. The reasons for late diagnosis are unclear, and efforts to improve survival will largely depend on efforts to diagnose HNC at an early stage. Patients with HPV-related versus HPV-unrelated oropharynx cancer had better survival, which supports previous results from Europe and North America. AUTHORS' DISCLOSURES OF POTENTIAL CONFLICTS OF INTEREST No COIs from the authors.


2010 ◽  
Vol 19 (2) ◽  
pp. 53-56 ◽  
Author(s):  
Nancy Lewis McColloch ◽  
William R. Carroll ◽  
J. Scott Magnuson

The combination of chemotherapy and radiation has emerged as a standard of care for patients diagnosed with head and neck cancer (HNC) of the oropharynx, the hypopharynx, and the larynx. Many devastating complications to the integrity of the swallow have been documented to occur with the swallowing mechanism, as a result of several chemoradiation protocols. These complications include decreased oral caloric intake, long-term reliance on feeding tubes for nutrition, weight loss, increased morbidity and mortality, decreased quality of life, and increased utilization of health-care services.


Oral Oncology ◽  
2020 ◽  
Vol 110 ◽  
pp. 104870 ◽  
Author(s):  
Nosayaba Osazuwa-Peters ◽  
Justin M. Barnes ◽  
Uchechukwu Megwalu ◽  
Eric Adjei Boakye ◽  
Kenton J. Johnston ◽  
...  

2019 ◽  
Vol 27 (2) ◽  
Author(s):  
J. Irish ◽  
J. Kim ◽  
J. Waldron ◽  
A.C. Wei ◽  
E. Winquist ◽  
...  

Background At the request of the Head and Neck Cancers Advisory Committee of Ontario Health (Cancer Care Ontario), a working group and expert panel of clinicians with expertise in the management of head-and-neck cancer developed the present guideline. The purpose of the guideline is to provide advice about the organization and delivery of health care services for adult patients with head-and-neck cancer. Methods This document updates the recommendations published in the Ontario Health (Cancer Care Ontario) 2009 organizational guideline The Management of Head and Neck Cancer in Ontario. The guideline development methods included an updated literature search, internal review by content and methodology experts, and external review by relevant health care providers and potential users. Results To ensure that all patients have access to the highest standard of care available in Ontario, the guideline establishes the minimum requirements to maintain a head-and-neck disease site program. Recommendations are made about the membership of core and extended provider teams, minimum skill sets and experience of practitioners, cancer centre–specific and practitioner-specific volumes, multidisciplinary care requirements, and unique infrastructure demands. Conclusions The recommendations contained in this document offer guidance for clinicians and institutions providing care for patients with head-and-neck cancer in Ontario, and for policymakers and other stakeholders involved in the delivery of health care services for head-and-neck cancer.    


Author(s):  
D.A. Rapkin ◽  
C.L. Williams ◽  
S. Lazaro ◽  
A.B. Madnick ◽  
F. Buen ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Codecà Carla ◽  
Ferrari Daris ◽  
Bertuzzi Cecilia ◽  
Broggio Francesca ◽  
Crepaldi Francesca ◽  
...  

Angiogenesis is a necessary process for tumor growth, progression and diffusion. In the last years many efforts have been made to understand the mechanisms necessary to the formation of new vessels in tumor tissue and how to integrate these findings in the treatment of different type of cancer. Thanks to these studies there are today many anti-angiogenic drugs with established activity in cancer and approved in clinical practice. Head and neck cancer is a common tumor worldwide that often has advanced stage at diagnosis and poor prognosis. Angiogenesis has a well recognized role in head and neck cancer progression and resistance to drugs and radiotherapy and many clinical trials has been conducted with antiangiogenic agents in this disease, even if they often showed limited efficacy. In this review we summarize the main trials published about angiogenesis in head and neck cancer with particular attention to factors involved in this process and the available data on the efficacy of treatment with anti-angiogenic agents in this disease.


2015 ◽  
Vol 54 (5) ◽  
pp. 759-766 ◽  
Author(s):  
Maja Halgren Olsen ◽  
Charlotte Rotbøl Bøje ◽  
Trille Kristina Kjær ◽  
Marianne Steding-Jessen ◽  
Christoffer Johansen ◽  
...  

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