scholarly journals Angiogenesis in Head and Neck Cancer: A Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Codecà Carla ◽  
Ferrari Daris ◽  
Bertuzzi Cecilia ◽  
Broggio Francesca ◽  
Crepaldi Francesca ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Progression ◽  
Neck Cancer ◽  
Tumor Tissue ◽  
Antiangiogenic Agents ◽  
Stage At Diagnosis ◽  
Review Of The Literature ◽  
Limited Efficacy ◽  
And Diffusion

Angiogenesis is a necessary process for tumor growth, progression and diffusion. In the last years many efforts have been made to understand the mechanisms necessary to the formation of new vessels in tumor tissue and how to integrate these findings in the treatment of different type of cancer. Thanks to these studies there are today many anti-angiogenic drugs with established activity in cancer and approved in clinical practice. Head and neck cancer is a common tumor worldwide that often has advanced stage at diagnosis and poor prognosis. Angiogenesis has a well recognized role in head and neck cancer progression and resistance to drugs and radiotherapy and many clinical trials has been conducted with antiangiogenic agents in this disease, even if they often showed limited efficacy. In this review we summarize the main trials published about angiogenesis in head and neck cancer with particular attention to factors involved in this process and the available data on the efficacy of treatment with anti-angiogenic agents in this disease.

The Impact of Smoking Cessation and Continuation on Recurrence and Survival in Patients with Head and Neck Cancer: A Systematic Review of the Literature

2020 ◽  
Vol 43 (10) ◽  
pp. 549-558
Author(s):  
Patricia R. von Kroge ◽  
Frederike Bokemeyer ◽  
Susanne Ghandili ◽  
Carsten Bokemeyer ◽  
Christoph Seidel
Keyword(s):  
Systematic Review ◽  
Smoking Cessation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Review Of The Literature ◽  
The Impact

scholarly journals The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2280
Author(s):  
Melissa B. Aldrich ◽  
John C. Rasmussen ◽  
Caroline E. Fife ◽  
Simona F. Shaitelman ◽  
Eva M. Sevick-Muraca
Keyword(s):  
Breast Cancer ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Neck Cancer ◽  
Cancer Metastasis ◽  
Near Infrared ◽  
Critical Role ◽  
Lymphatic Function

Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitating functional outcomes. In this review, we describe how cancer metastasis, lymph node dissection, and radiation therapy alter lymphatic function, as visualized by near-infrared fluorescence lymphatic imaging. Using custom gallium arsenide (GaAs)-intensified systems capable of detecting trace amounts of indocyanine green administered repeatedly as lymphatic contrast for longitudinal clinical imaging, we show that lymphatic dysfunction occurs with cancer progression and treatment and is an early, sub-clinical indicator of cancer-acquired lymphedema. We show that early treatment of lymphedema can restore lymphatic function in breast cancer and head and neck cancer patients and survivors. The compilation of these studies provides insights to the critical role that the lymphatics and the immune system play in the etiology of lymphedema and associated co-morbidities.

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