Prospective investigation and literature review of tolerance dose on salivary glands using quantitative salivary gland scintigraphy in the intensity-modulated radiotherapy era

Head & Neck ◽  
2016 ◽  
Vol 38 (S1) ◽  
pp. E1746-E1755 ◽  
Author(s):  
Sea-Won Lee ◽  
Keon Wook Kang ◽  
Hong-Gyun Wu
Keyword(s):  
Salivary Gland ◽  
Literature Review ◽  
Salivary Glands ◽  
Intensity Modulated Radiotherapy ◽  
Salivary Gland Scintigraphy ◽  
Intensity Modulated ◽  
Tolerance Dose ◽  
Prospective Investigation

Mathematical evaluation of post-radiotherapy salivary gland function using salivary gland scintigraphy

2021 ◽  
Author(s):  
Tomohiro Itonaga ◽  
Koichi Tokuuye ◽  
Ryuji Mikami ◽  
Akira Shimizu ◽  
Hiroki Sato ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Conformal Radiotherapy ◽  
Head And Neck Carcinoma ◽  
Salivary Gland Function ◽  
Salivary Gland Scintigraphy ◽  
Radiotherapy Group ◽  
Tolerance Dose ◽  
Gland Function ◽  
Mathematical Evaluation

Objective: Xerostomia is the most common treatment-related toxicity after radiotherapy (RT) for head and neck carcinoma, reducing the quality of life of patients due to a decrease in salivary gland function. Methods: Salivary gland scintigraphy was performed to quantitatively evaluate the salivary gland functions in patients undergoing RT. It was done chronologically for 62 salivary glands of 31 patients before RT and retested 12 months later. Results: The salivary gland functions of most patients deteriorated post-RT and recovered when the radiation dose to the salivary gland was not high. The mean dose to the salivary gland was found to be the most reliable factor in deteriorating salivary gland function, and the tolerance dose was determined to be 46 Gy. The recovery rate of salivary gland function after 1 year of RT was 72% in the RT alone group (n = 10), 56% in the conformal radiotherapy group (n = 15), and 44% in the bioradiotherapy group (n = 6). Conclusion: Scintigraphy revealed that the salivary glands recovered from post-RT hypofunction when decreased doses were administered. The determined tolerance dose of 46 Gy may guide the approach to minimizing associated xerostomia in RT. Advances in knowledge: In this study, the average tolerated dose to the salivary glands was 46 Gy.

scholarly journals Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Sunmi Jo ◽  
Hye-kyung Shim ◽  
Joo Yeon Kim ◽  
Sang Kyun Bae ◽  
Mi Ra Kim
Keyword(s):  
Salivary Gland ◽  
Literature Review ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Diagnostic Methods ◽  
Myeloid Sarcoma ◽  
Histopathologic Evaluation ◽  
High Index Of Suspicion ◽  
Sebaceous Lymphadenoma

Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the parotid gland, through a total parotidectomy with neck dissection. After an extensive histopathological review that included immunohistochemistry, a pathologic diagnosis of MS with infiltration into the sebaceous lymphadenoma with concurrent BM involvement was confirmed. MS is difficult to diagnose accurately; herein, we analyzed the clinical presentations and effectiveness of the various diagnostic methods with a review of the literature. There are 17 cases, including our case, reported in 13 studies. Of the cases in which the salivary glands were affected, 10 involved the parotid gland, six involved the submandibular gland, and one involved both. Isolated invasion of the salivary gland was found in one case of parotid gland invasion and three cases of submandibular gland invasion. In 13 cases, the salivary glands were affected by various other lesions. Although there were no incidences of isolated MS, six patients were diagnosed with secondary MS and eight patients with MS with BM involvement, including this case. The diagnosis of MS is difficult given its rarity, and a high index of suspicion and integrated radiologic and careful histopathologic evaluation are required. Most cases of MS infiltrating the salivary gland might be indicated by the possibility of BM involvement. MS with BM involvement predicts poor prognosis and the need for intensive systemic treatment.

Intensity-modulated radiotherapy or volumetric-modulated arc therapy in patients with head and neck cancer: Focus on salivary glands dosimetry

Head & Neck ◽  
2016 ◽  
Vol 38 (7) ◽  
pp. 1028-1034 ◽  
Author(s):  
Alexis Vallard ◽  
Jean-Baptiste Guy ◽  
Sylvie Mengue Ndong ◽  
Nicolas Vial ◽  
Romain Rivoirard ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Salivary Glands ◽  
Neck Cancer ◽  
Volumetric Modulated Arc Therapy ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated ◽  
Arc Therapy
Sign in / Sign up

Export Citation Format

Share Document