Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: Relationships with prognosis

Head & Neck ◽  
2005 ◽  
Vol 27 (11) ◽  
pp. 982-989 ◽  
Author(s):  
Fernanda C. G. Sampaio-Góes ◽  
Denise T. Oliveira ◽  
Regina G. Dorta ◽  
Suely Nonogaki ◽  
Gilles Landman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Poorly Differentiated ◽  
Basaloid Squamous

scholarly journals Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Silas Antonio Juvencio de Freitas Filho ◽  
Cláudia Malheiros Coutinho-Camillo ◽  
Katia Klug Oliveira ◽  
Bárbara Beltrame Bettim ◽  
Clóvis Antônio Lopes Pinto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Basaloid Squamous Cell Carcinoma ◽  
Poorly Differentiated ◽  
Basaloid Squamous

Background. The present study aimed to investigate the clinical significance and prognostic value of the immunoexpression of cancer stem cell markers, ALDH1 and Notch1, in subtypes of oral squamous cell carcinoma. Materials and Methods. The expression of ALDH1 and Notch1 in 63 patients with well and poorly differentiated oral squamous cell carcinomas and their subtypes, verrucous carcinoma and basaloid squamous cell carcinoma, was evaluated by immunohistochemistry. The semi-quantitative analysis of the ALDH1 and Notch immunoexpression levels, based on the capture of 10 microscopic fields, at 400X magnification, at the invasive tumor front was performed and associated with clinicopathological variables using the chi-square test or Fisher’s exact test. The overall and disease-free survival rates were estimated according to the Kaplan–Meier method and the curves were compared using the log-rank test. The independent effects of variables were calculated using Cox’s proportional hazards regression model. Results. Strong ALDH1 and Notch1 expression was observed in 16 (25.4%) and 27 (42.9%) oral squamous cell carcinomas including their subtypes, respectively. Most tumors with strong immunoexpression of ALDH1 were basaloid squamous cell carcinoma (56.3%). Statistically significant associations were observed between the strong immunoexpression of Notch1 in poorly differentiated oral squamous cell carcinoma with perineural infiltration ( p  = 0.011) and lymph node involvement (pN+) ( p  = 0.034). The strong immunoexpression of ALDH1 was a prognostic factor associated with worse overall survival ( p  = 0.040) for patients with oral cancer. Conclusion. The strong immunoexpression of Notch1 can contribute to identification of patients with poorly differentiated oral squamous cell carcinoma, who have perineural infiltration or lymph node metastasis. In addition, the strong immunoexpression of ALDH1 may help to identify a worse prognosis in patients with oral squamous cell carcinoma and their subtypes.

scholarly journals Pulmonary metastasectomy for esophageal basaloid squamous cell carcinoma component at 66 months after esophagectomy

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kumiko Sekiguchi ◽  
Takeshi Matsutani ◽  
Tsutomu Nomura ◽  
Nobutoshi Hagiwara ◽  
Akihisa Matsuda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pulmonary Metastasectomy ◽  
Basaloid Squamous Cell Carcinoma ◽  
Basaloid Squamous

scholarly journals Cutaneous metastasis from esophageal basaloid squamous cell carcinoma: A case report

2021 ◽  
Vol 80 ◽  
pp. 105621
Author(s):  
Fumitaka Endo ◽  
Yuji Akiyama ◽  
Masazumi Onishi ◽  
Noriyuki Uesugi ◽  
Tamotsu Sugai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Metastasis ◽  
Basaloid Squamous Cell Carcinoma ◽  
Basaloid Squamous

scholarly journals Prognostic value of p27Kip1expression in Basaloid Squamous Cell Carcinoma of the larynx

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Grazia Salerno ◽  
Dolores Di Vizio ◽  
Stefania Staibano ◽  
Giampiero Mottola ◽  
Giuseppe Quaremba ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Basaloid Squamous

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis

2021 ◽  
pp. 106689692199713
Author(s):  
Jijgee Munkhdelger ◽  
Tomoko Shimooka ◽  
Yoshinori Koyama ◽  
Sadakatsu Ikeda ◽  
Yoshiki Mikami ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Pik3ca Mutation ◽  
Biological Behavior ◽  
Basaloid Squamous Cell Carcinoma ◽  
Surgical Specimen ◽  
Molecular Alterations ◽  
Basaloid Squamous

There is a lack of knowledge about molecular alterations in basaloid squamous cell carcinoma (BSCC) of the uterine cervix. A 72-year-old woman with a history of previous subtotal hysterectomy and current vaginal bleeding was referred to our hospital. Initially, adenoid cystic carcinoma (ACC) was diagnosed upon cervical cytology and biopsy. Chest imaging showed multiple metastatic lesions in both lungs. The surgical specimen showed BSCC with diffuse p16 immunoreactivity and negativity for S-100, c-kit, and neuroendocrine markers. There was a focal minor ACC component, which could have explained the previous cytology and biopsy diagnosis. Next-generation sequencing with two different panels showed coexisting PIK3CA mutation and NTRK2 fusion with 10 additional variants of unknown significance ( ATR, DAXX, FAM123B, JAK1, KEL, MLL2, NOTCH2, PALB2, POLD1, POLE). The MYB gene fusions were not identified. The patient received chemotherapy with TRK inhibitor larotrectinib and carboplatin, which caused shrinkage of metastatic lung nodules. This is the first report of cervical BSCC with extensive molecular workup, which detected multiple genetic events, including targetable ones, which are potentially implicated in the development of a tumor. The accumulation of data and further studies on this tumor are necessary to define its diagnostic criteria and its clinical and biological behavior.

scholarly journals Pure Basaloid Squamous Cell Carcinoma of the Uterine Cervix: A Case Report

2009 ◽  
Vol 24 (3) ◽  
pp. 542 ◽  
Author(s):  
Yong Soon Kwon ◽  
Yong Man Kim ◽  
Ga Won Choi ◽  
Young Tak Kim ◽  
Joo-Hyun Nam
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Basaloid Squamous Cell Carcinoma ◽  
Basaloid Squamous

scholarly journals Basaloid squamous cell carcinoma of the tonsil: report of a case and review of the literature

2012 ◽  
Vol 5 ◽  
pp. 447-450
Author(s):  
Deviprasad Shetty ◽  
Vijayalakshmi Subramaniam ◽  
Adarsha Herale ◽  
Prema Saldanha ◽  
Mahaveer Jain
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Review Of The Literature ◽  
Basaloid Squamous
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