scholarly journals Altered single‐subject gray matter structural networks in drug‐naïve attention deficit hyperactivity disorder children

2021 ◽  
Author(s):  
Ying Chen ◽  
Du Lei ◽  
Hengyi Cao ◽  
Running Niu ◽  
Fuqin Chen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gray Matter ◽  
Attention Deficit ◽  
Single Subject ◽  
Hyperactivity Disorder ◽  
Drug Naïve ◽  
Structural Networks

Altered Single-Subject Gray Matter Structural Networks in Drug-Naïve ADHD Children

2021 ◽  
Vol 89 (9) ◽  
pp. S107
Author(s):  
Ying Chen ◽  
Du Lei ◽  
Hengyi Cao ◽  
Qiyong Gong
Keyword(s):  
Gray Matter ◽  
Single Subject ◽  
Adhd Children ◽  
Drug Naïve ◽  
Structural Networks

scholarly journals Sleep EEG slow-wave activity in medicated and unmedicated children and adolescents with attention-deficit/hyperactivity disorder

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Melanie Furrer ◽  
Valeria Jaramillo ◽  
Carina Volk ◽  
Maya Ringli ◽  
Robert Aellen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Children And Adolescents ◽  
Gray Matter ◽  
Attention Deficit ◽  
Stimulant Medication ◽  
Wave Activity ◽  
Healthy Controls ◽  
Synaptic Density ◽  
Hyperactivity Disorder ◽  
Gray Matter Volumes

AbstractSlow waves (1–4.5 Hz) are the most characteristic oscillations of deep non-rapid eye movement sleep. The EEG power in this frequency range (slow-wave activity, SWA) parallels changes in cortical connectivity (i.e., synaptic density) during development. In patients with attention-deficit/hyperactivity disorder (ADHD), prefrontal cortical development was shown to be delayed and global gray matter volumes to be smaller compared to healthy controls. Using data of all-night recordings assessed with high-density sleep EEG of 50 children and adolescents with ADHD (mean age: 12.2 years, range: 8–16 years, 13 female) and 86 age- and sex-matched healthy controls (mean age: 12.2 years, range: 8–16 years, 23 female), we investigated if ADHD patients differ in the level of SWA. Furthermore, we examined the effect of stimulant medication. ADHD patients showed a reduction in SWA across the whole brain (−20.5%) compared to healthy controls. A subgroup analysis revealed that this decrease was not significant in patients who were taking stimulant medication on a regular basis at the time of their participation in the study. Assuming that SWA directly reflects synaptic density, the present findings are in line with previous data of neuroimaging studies showing smaller gray matter volumes in ADHD patients and its normalization with stimulant medication.

scholarly journals Gray Matter Alterations in Adults with Attention-Deficit/Hyperactivity Disorder Identified by Voxel Based Morphometry

2011 ◽  
Vol 69 (9) ◽  
pp. 857-866 ◽  
Author(s):  
Larry J. Seidman ◽  
Joseph Biederman ◽  
Lichen Liang ◽  
Eve M. Valera ◽  
Michael C. Monuteaux ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Gray Matter ◽  
Attention Deficit ◽  
Voxel Based Morphometry ◽  
Hyperactivity Disorder
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