scholarly journals Aberrant functional brain network dynamics in patients with functional constipation

2021 ◽  
Author(s):  
Tao Yin ◽  
Zhaoxuan He ◽  
Peihong Ma ◽  
Ruirui Sun ◽  
Kunnan Xie ◽  
...  
Keyword(s):  
Network Dynamics ◽  
Functional Constipation ◽  
Brain Network ◽  
Functional Brain ◽  
Functional Brain Network

scholarly journals Genetic and neuroanatomical support for functional brain network dynamics in epilepsy

2018 ◽  
Author(s):  
Pranav G. Reddy ◽  
Richard F. Betzel ◽  
Ankit N. Khambhati ◽  
Preya Shah ◽  
Lohith Kini ◽  
...  
Keyword(s):  
White Matter ◽  
Large Scale ◽  
Focal Epilepsy ◽  
Network Dynamics ◽  
Brain Network ◽  
Brain Anatomy ◽  
Functional Brain ◽  
Genetic Constraints ◽  
Number Of Patients ◽  
Functional Brain Network

AbstractFocal epilepsy is a devastating neurological disorder that affects an overwhelming number of patients world-wide, many of whom prove resistant to medication. The efficacy of current innovative technologies for the treatment of these patients has been stalled by the lack of accurate and effective methods to fuse multimodal neuroimaging data to map anatomical targets driving seizure dynamics. Here we propose a parsimonious model that explains how large-scale anatomical networks and shared genetic constraints shape inter-regional communication in focal epilepsy. In extensive ECoG recordings acquired from a group of patients with medically refractory focal-onset epilepsy, we find that ictal and preictal functional brain network dynamics can be accurately predicted from features of brain anatomy and geometry, patterns of white matter connectivity, and constraints complicit in patterns of gene coexpression, all of which are conserved across healthy adult populations. Moreover, we uncover evidence that markers of non-conserved architecture, potentially driven by idiosyncratic pathology of single subjects, are most prevalent in high frequency ictal dynamics and low frequency preictal dynamics. Finally, we find that ictal dynamics are better predicted by white matter features and more poorly predicted by geometry and genetic constraints than preictal dynamics, suggesting that the functional brain network dynamics manifest in seizures rely on – and may directly propagate along – underlying white matter structure that is largely conserved across humans. Broadly, our work offers insights into the generic architectural principles of the human brain that impact seizure dynamics, and could be extended to further our understanding, models, and predictions of subject-level pathology and response to intervention.

Functional brain network dynamics based on the Hindmarsh–Rose model

2021 ◽  
Author(s):  
Guiyang Lv ◽  
Nayue Zhang ◽  
Kexin Ma ◽  
Jian Weng ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Network Dynamics ◽  
Brain Network ◽  
Functional Brain ◽  
Functional Brain Network

scholarly journals Complexity in Relational Processing Predicts Changes in Functional Brain Network Dynamics

2013 ◽  
Vol 24 (9) ◽  
pp. 2283-2296 ◽  
Author(s):  
Luca Cocchi ◽  
Graeme S. Halford ◽  
Andrew Zalesky ◽  
Ian H. Harding ◽  
Brentyn J. Ramm ◽  
...  
Keyword(s):  
Network Dynamics ◽  
Brain Network ◽  
Relational Processing ◽  
Functional Brain ◽  
Functional Brain Network

Functional brain network reorganization in HIV infection

2021 ◽  
Author(s):  
Silvia Minosse ◽  
Eliseo Picchi ◽  
Francesca Di Giuliano ◽  
Loredana Sarmati ◽  
Elisabetta Teti ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Brain Network ◽  
Functional Brain ◽  
Functional Brain Network ◽  
Brain Network Reorganization
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