scholarly journals White matter degeneration revealed by fiber‐specific analysis relates to recovery of hand function after stroke

2021 ◽  
Author(s):  
Bastian Cheng ◽  
Marvin Petersen ◽  
Robert Schulz ◽  
Marlene Boenstrup ◽  
Lutz Krawinkel ◽  
...  
Keyword(s):  
White Matter ◽  
Hand Function ◽  
White Matter Degeneration ◽  
Specific Analysis

Are Gait Disturbances and White Matter Degeneration Early Indicators of Vascular Dementia?

1994 ◽  
Vol 5 (3-4) ◽  
pp. 197-202 ◽  
Author(s):  
Michael G. Hennerici ◽  
Manfred Oster ◽  
Simon Cohen ◽  
Andreas Schwartz ◽  
Lillian Motsch ◽  
...  
Keyword(s):  
White Matter ◽  
Vascular Dementia ◽  
White Matter Degeneration ◽  
Gait Disturbances ◽  
Early Indicators

scholarly journals A novel animal model for neuroinflammation and white matter degeneration

2017 ◽  
Author(s):  
Baohu Ji ◽  
Kerin Higa ◽  
Virawudh Soontornniyomkij ◽  
Atsushi Miyanohara ◽  
Xianjin Zhou
Keyword(s):  
Animal Model ◽  
Immune System ◽  
White Matter ◽  
Innate Immune System ◽  
D1 Receptor ◽  
Innate Immune ◽  
Small Interference Rna ◽  
Cell Defense ◽  
White Matter Degeneration ◽  
Short Hairpin Rnas

Small interference RNA has been widely used to suppress gene expression. Three different short-hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal Drd1 expression. Transduction of mouse striatum with all 3 scAAV8-D1shRNA virus, but not the control scAAV8 virus, causes extensive neuroinflammation, demyelination, and axon degeneration. RNA interference is known to be coupled to the innate immune system as a host cell defense against virus infection. Activation of the innate immune system may play a causal role in the development of neuroinflammation and white matter degeneration, providing a novel animal model for multiple sclerosis (MS) and other neuroinflammatory diseases.

scholarly journals Chronic White Matter Degeneration, but No Tau Pathology at One-Year Post-Repetitive Mild Traumatic Brain Injury in a Tau Transgenic Model

2019 ◽  
Vol 36 (4) ◽  
pp. 576-588 ◽  
Author(s):  
Benoit Mouzon ◽  
Corbin Bachmeier ◽  
Joseph Ojo ◽  
Christopher Acker ◽  
Scott Ferguson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Mild Traumatic Brain Injury ◽  
Tau Pathology ◽  
Transgenic Model ◽  
White Matter Degeneration ◽  
One Year
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